Savaş Tay

Accurate processing of short-pulsed immune signals by single macrophages — analysis code and data

Gabriel Mercado-Vasquez, James Vizzard, Betul Celiker, Junjie Xia et autres

MATLAB analysis code and associated data for the manuscript "Accurate processing of short-pulsed immune signals by single macrophages." This archive contains the figure-generation scripts (Fig1-6.m, SubFig1/2/5/7.m), supporting functions, and raw/processed data files used to produce the figures in the paper, including microfluidic …

Accurate processing of short-pulsed immune signals by single macrophages — analysis code and data

Gabriel Mercado-Vasquez, James Vizzard, Betul Celiker, Junjie Xia et autres

MATLAB analysis code and associated data for the manuscript "Accurate processing of short-pulsed immune signals by single macrophages." This archive contains the figure-generation scripts (Fig1-6.m, SubFig1/2/5/7.m), supporting functions, and raw/processed data files used to produce the figures in the paper, including microfluidic …

Spatial proximity sequencing maps developmental dynamics in the Germinal Center 2332687

Huili Wang, Bijentimala Keisham, Abinash Padhi, Yan Li et autres

us (code pays fourni par la source)

Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport

Sneha Kesaraju, Yueying Li, Junjie Xing, Mobarakeh Ghadiri et autres

us, cn (code pays fourni par la source)

Massively multiplexed microfluidics maps combinatorial and sequential antibiotic responses in 3D

Yong Jun Jeong, Gabriel Mercado-Vasquez, Abinash Padhi, J. Matthews et autres

Current microbial culture and antibiotic susceptibility testing platforms lack dynamic chemical control and do not scale to high-throughput 3D culture. We present an automated microfluidic system that creates 512 independently programmable 3D hydrogel-culture chambers and delivers each chamber a distinct combinatorial and …

us (code pays fourni par la source)

Accurate processing of ultra-short immune signals by single macrophages

Gabriel Mercado-Vasquez, James Vizzard, Betul Celiker, Junjie Xia et autres

Accurately interpreting short-lived signals is challenging within noisy cellular microenvironments. It is not known if cells can distinguish different signaling molecules under transient exposure. Here, we explored the temporal limits of signal detection by single macrophages. Microfluidic experiments monitoring NF-kB dynamics showed …

us (code pays fourni par la source)

Mo1452: INFLAMMATION-INDUCED CLAUDIN-2 UPREGULATION LIMITS PANCREATITIS PROGRESSION BY ENHANCING TIGHT JUNCTIONCONTROLLED PANCREATIC DUCTAL TRANSPORT

Sneha Kesaraju, Junjie Xing, Yueying Li, Melissa Tracy et autres

Publisher Correction: Herpesviruses mimic zygotic genome activation to promote viral replication

Eva Neugebauer, Stephanie Wälter, Tan Jiang, Nir Drayman et autres

Author notes These authors contributed equally: Eva Neugebauer, Stephanie Walter, Jiang Tan. Authors and Affiliations Institute of Virology, University Medical Center, and Faculty of Medicine, Albert-Ludwig-University Freiburg, Freiburg, Germany Eva Neugebauer, Jiang Tan, Sandra Pennisi, Pia Veratti, Karla S. Stein, Isabelle Welker …

de, us, nl (code pays fourni par la source)

Macrophage memory emerges from coordinated transcription factor and chromatin dynamics

Andrew G. Wang, Minjun Son, Aleksandr Gorin, Emma Kenna et autres

us (code pays fourni par la source)

Herpesviruses mimic zygotic genome activation to promote viral replication

Eva Neugebauer, Stephanie Wälter, Tan Jiang, Nir Drayman et autres

Zygotic genome activation (ZGA) is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In humans, ZGA is induced by DUX4, a pioneer factor that drives expression …

de, us, nl (code pays fourni par la source)

Single-cell chemoproteomics identifies metastatic activity signatures in breast cancer

Kavya Smitha Pillai, Olivia C. Laxton, Gang Li, Jing Lin et autres

Protein activity state, rather than protein or mRNA abundance, is a biologically regulated and relevant input to many processes in signaling, differentiation, development, and diseases such as cancer. While there are numerous methods to detect and quantify mRNA and protein abundance in …

us (code pays fourni par la source)

A drug repurposing screen identifies decitabine as an HSV-1 antiviral

Cody Sirimanotham, Jason A. Espinoza, Dillon Cheng, Savaş Tay et autres

ABSTRACT Herpes simplex virus type 1 (HSV-1) is a highly prevalent human pathogen that causes a range of clinical manifestations, including oral and genital herpes, keratitis, encephalitis, and disseminated neonatal disease. Despite its significant health and economic burden, there is currently only …

us (code pays fourni par la source)