Accurate processing of ultra-short immune signals by single macrophages
Gabriel Mercado-Vasquez, James Vizzard, Betul Celiker, Junjie Xia et autres
Accurately interpreting short-lived signals is challenging within noisy cellular microenvironments. It is not known if cells can distinguish different signaling molecules under transient exposure. Here, we explored the temporal limits of signal detection by single macrophages. Microfluidic experiments monitoring NF-kB dynamics showed …
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bioRxiv (Cold Spring Harbor Laboratory)