Patrycja Pawlikowska

Tet2 deficiency promotes IgG1+ B‐cell expansion and differentiation blockade through deregulation of the Nfkbia –c‐Rel axis

Hussein Ghamlouch, Michaël Degaud, Veronique Della‐Valle, Alexandre Eeckhoutte et autres

Abstract The germinal center (GC) reaction is essential for orchestrating humoral immunity by producing plasma cells (PCs) and memory B cells (MBCs). TET2, an α‐ketoglutarate‐dependent dioxygenase, plays a critical role in B‐cell exit from the GC and in plasma cell differentiation. Moreover, …

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Isolation and Sequencing of Single Circulating Tumor Cells

Marianne Oulhen, Maria Virginia Sanchez-Becerra, Patrycja Pawlikowska, Françoise Farace

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EF-FACS circulating tumor cell detection complements ctDNA-based prognosis in stratification of non-small cell lung cancer patients

Maria Virginia Sanchez-Becerra, Marianne Oulhen, Damien Drubay, Jordi Remón et autres

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190eP EF-FACS circulating tumor cells (CTC) detection complements circulating tumor DNA (ctDNA)-based prognostic stratification of non-small cell lung cancer (NSCLC) patients

M.V. Sánchez Becerra, Marianne Oulhen, Damien Drubay, Jordi Remon Masip et autres

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Editorial: Predictive and prognostic value of liquid biopsy biomarkers in metastatic cancers: from basic science, across high throughput profiling up to clinical practice

Dorota Malgorzata Kwapisz, Patrycja Pawlikowska, Areti D. Strati

We are pleased to introduce this special issue entitled "Predictive and Prognostic Value of Liquid Biopsy Biomarkers in Metastatic Cancers: from Basic Science, across High Throughput Profiling up to Clinical Practice". This collection includes papers exploring a variety of topics related to …

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FANCA deficiency promotes leukaemic progression by allowing the emergence of cells carrying oncogenic driver mutations

Patrycja Pawlikowska, Laure Delestré, Sebastian Gregoricchio, Alessia Oppezzo et autres

Leukaemia is caused by the clonal evolution of a cell that accumulates mutations/genomic rearrangements, allowing unrestrained cell growth. However, recent identification of leukaemic mutations in the blood cells of healthy individuals revealed that additional events are required to expand the mutated clones …

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Insight into Intratumoral Heterogeneity Through Single CTC Sequencing and CDX Analysis

Marianne Oulhen, Tala Tayoun, Agathe Aberlenc, Patrycja Pawlikowska et autres

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Abstract 1951: Circulating tumor cell-derived explant models reveal DNA damage response-based therapeutic opportunities in non-small cell lung cancer

Tala Tayoun, Vincent Faugeroux, Marianne Oulhen, Olivier Déas et autres

Abstract Background: DNA damage and genomic instability contribute to non-small cell lung cancer (NSCLC) etiology and progression. However, their therapeutic exploitation is disappointing. CTC-derived eXplants (CDX) offer systems for mechanistic investigation of CTC metastatic potency and biology-driven therapeutic testings. We perform in-depth …

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Targeting genome integrity dysfunctions impedes metastatic potency in non–small cell lung cancer circulating tumor cell–derived explants

Tala Tayoun, Vincent Faugeroux, Marianne Oulhen, Olivier Déas et autres

DNA damage and genomic instability contribute to non-small cell lung cancer (NSCLC) etiology and progression. However, their therapeutic exploitation is disappointing. CTC-derived explants (CDX) offer systems for mechanistic investigation of CTC metastatic potency and may provide rationale for biology-driven therapeutics. Four CDX …

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Circulating tumor cell copy-number heterogeneity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

Marianne Oulhen, Patrycja Pawlikowska, Tala Tayoun, Marianna Garonzi et autres

Abstract Gatekeeper mutations are identified in only 50% of the cases at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors (TKIs). Circulating tumor cells (CTCs) are relevant tools to identify additional resistance mechanisms and can be sequenced at the single-cell level. Here, …

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Abstract 595: Patterns and dynamics of genome instability drive metastatic activity in non-small cell lung cancer (NSCLC) circulating tumor cell (CTC)-derived xenograft (CDX) models

Tala Tayoun, Vincent Faugeroux, Marianne Oulhen, Emma Pailler et autres

Abstract Background: CDX models have emerged as tractable systems to explore mechanisms involved in metastatic progression and tumor-initiating properties of CTCs. However, their development is challenging due to low prevalence of CTCs in patient blood. We report the genomic and functional characterization …

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Tumor Evolution and Therapeutic Choice Seen through a Prism of Circulating Tumor Cell Genomic Instability

Tala Tayoun, Marianne Oulhen, Agathe Aberlenc, Françoise Farace et autres

Circulating tumor cells (CTCs) provide an accessible tool for investigating tumor heterogeneity and cell populations with metastatic potential. Although an in-depth molecular investigation is limited by the extremely low CTC count in circulation, significant progress has been made recently in single-cell analytical …

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