Yasutaka Murai

Mucus Plugs Associated With Dupilumab Induction in Severe Asthma

Toshiyuki Koya, Yasutaka Murai, Masanori Tanaka, Takeshi Matsuda et autres

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Effects of Benralizumab on Mucus Plugs in Eosinophilic Severe Asthma

Tomoki Matsuda, Toshiyuki Koya, Nobuyuki Sakai, Manabu Tanaka et autres

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Supplementary Material for: Effect of benralizumab on mucus plugs in severe eosinophilic asthma

Nobuyuki Sakai, Toshiyuki Koya, Yasutaka Murai, Fumito Tsubokawa et autres

Introduction: Mucus plugs are associated with airway obstruction in severe asthma and are involved in the formation of activated eosinophils. Benralizumab, an anti-interleukin-5 receptor antibody, markedly reduces not only peripheral blood eosinophils but also airway eosinophils; however, its effects on mucus plugs …

The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action

Yuki Kitao, Tadataka Saito, Satoshi Watanabe, Yasuhiro Ohe et autres

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The Discovery of 3,3-Dimethyl-1,2, 3,4-Tetrahydroquinoxaline-1-Carboxamide As AMPD2 Inhibitors With a Novel Mechanism of Action

Yuki Kitao, Tadataka Saito, Satoshi Watanabe, Yasuhiro Oe et autres

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Clinical Features of Asthma Patients with High-Intensity Treatment Based on Questionnaire Survey in Niigata, Japan

Yasutaka Murai, Yuka Kimura, Toshiyuki Koya, Takafumi Hasegawa et autres

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Analysis of haemodynamics and angiogenic response to ischaemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Lepr fa (SDT fatty) rats

Yasutaka Murai, Tomohiko Sasase, Hironobu Tadaki, Shiro Heitaku et autres

Abstract Peripheral artery disease (PAD) is defined as peripheral blood flow impairment, especially in the legs, caused by atherosclerotic stenosis. The disease decreases quality of life because of intermittent claudication or necrosis of the leg. The hindlimb ischaemia model, in which ischaemia …

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Author response for "Analysis of hemodynamics and angiogenic response to ischemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Lepr fa (SDT fatty) rats"

Yasutaka Murai, Tomohiko Sasase, Hironobu Tadaki, Shiro Heitaku et autres

Investigation of Pharmacological Responses to an Anti-Diabetic Drug Pioglitazone in Female Spontaneously Diabetic Torii (SDT) Fatty Rats, A New Obese Type 2 Diabetic Rat

Yasutaka Murai, K Miyajima, Masami Shinohara, Takahisa Yamada et autres

Rigorous glycemic control is essential to prevent the development of diabetes and onset of diabetic complications. Peroxisome proliferator-activated receptor (PPAR) γ activator pioglitazone is an anti-diabetic drug that exhibits glucose-lowering effects by enhancing insulin sensitivity in peripheral tissues. However, increases in body …

Usefulness of Obese Animal Models in Antiobesity Drug Development

Takeshi Ohta, Yasutaka Murai, Takahisa Yamada

Obese animal models have played key roles to elucidate the etiology of obesity and develop antiobesity drugs. In the first half of the chapter, we introduce the characteristics of obese animal models. In the second half of the chapter, we show the …

Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model

Yasutaka Murai, Takeshi Ohta, Hironobu Tadaki, Katsuhiro Miyajima et autres

INTRODUCTION: The number of diabetic patients has recently been increasing worldwide, and numerous anti-diabetic drugs have been developed to induce good glycemic control. In particular, metformin, which exhibits glucose-lowering effects by suppressing gluconeogenesis in the liver, is widely used as a first …

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The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity

Gi‐Wook Hwang, Yasutaka Murai, Tsutomu Takahashi, Akira Naganuma

Methylmercury causes serious damage to the central nervous system, but the molecular mechanisms of methylmercury toxicity are only marginally understood. In this study, we used a gene-deletion mutant library of budding yeast to conduct genome-wide screening for gene knockouts affecting the sensitivity …

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