Tomohiko Sasase

Glucose transporter 9 inhibition as a potential novel approach for lowering uric acid

Katsuya Deai, Kenji Fukui, Shiori Naruoka, Yuichi Shinozaki et autres

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Cerebral glucose uptake and cognitive functions: A phenome-wide Mendelian randomization study

Masatoshi Ueda, Takashi Suzuki, Toshiki Yoshimizu, Takahiro Konuma et autres

Background Based on both physiological perspectives and observational findings, increasing cerebral glucose uptake appears to be a novel therapeutic strategy to preserve cognitive function in patients with Alzheimer’s disease (AD). However, the inherent limitations of observational studies make it difficult to establish …

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Effects of a Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin on Pancreas in Obese Diabetic Mice

RYOKO SEKIKAWA, Hikari Uehara, Kinuko Uno, Tomohiko Sasase et autres

BACKGROUND/AIM: Insulin secretion deficiency is one of the factors that cause onset and progression of type 2 diabetes, and pancreatic β-cell mass is also reduced in patients with type 2 diabetes. Some anti-diabetic drugs act directly on the pancreas to promote insulin …

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Effects of sex hormones on the development of diabetes and pancreatic islet gene expression in obese type 2 diabetes model ZFDM rat

Norihide Yokoi, Saki Shigenaka, Chiaki Nakata, Misato Takagi et autres

Sex differences have been observed in the onset of type 2 diabetes, with men being more likely to develop the disease than women. There is a clear sex difference in the development of diabetes in obese type 2 diabetes model ZFDM rats, …

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A high-fat/high-sucrose/high-cholesterol diet leads to early indications of metabolic dysfunction-associated steatohepatitis-like lesions in obese diabetic mice

Kinuko Uno, Kodai Shirasaka, Yamato Muro, Fuko Kuroki et autres

Chronic hyperlipidemia and/ or hyperglycemia can impair various organs, such as the liver, kidney, and pancreas, through metabolic abnormalities. Metabolic dysfunction-associated steatohepatitis (MASH), related from nonalcoholic steatohepatitis (NASH), exhibits complex pathophysiological features, and animal models of MASH are essential for elucidating its …

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Progressive islet remodeling during the prediabetic stage in female SDT rats

Nodoka KAGAMI, Tomohiko Sasase, Kinuko Uno, Noriko Suzuki‐Kemuriyama et autres

Prediabetes represents a critical stage in the progression to type 2 diabetes, during which early alterations in pancreatic islet structure and function occur. We investigated temporal histopathological changes associated with islet remodeling in female Spontaneously Diabetic Torii (SDT) rats, a non-obese type …

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Effects of Hypertension Induced by 0.3% Saline Loading on Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats

Rina Takagi, Yoshiaki Tanaka, Tetsuya Hasegawa, Masami Shinohara et autres

Objective: This study aimed to determine the possibility of creating a new animal model in which diabetic retinopathy (DR) progresses due to hypertension caused by salt loading. Methods: Male Spontaneously Diabetic Torii (SDT) fatty rats were divided into two groups: one group …

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Spontaneously Diabetic Torii Fatty Rat Shows Early Stage of Diabetic Retinopathy Characterized by Capillary Changes and Inflammation

Kasumi Kikuchi, Miyuki Murata, Yasushi Kageyama, Masami Shinohara et autres

Purpose: The Spontaneously Diabetic Torii (SDT) fatty rat is an animal model of obese Type 2 diabetes. We previously reported that the SDT fatty rats develop diabetic cataracts. This study aimed to elucidate early diabetic changes in the retina of the SDT …

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High-fat/high-sucrose diet-induced renal changes in obese diabetic mice: a comparison with db/db and KK-Ay mice

Chikatake OKI, Kinuko Uno, Tomohiko Sasase, Takahiro Tsutsui et autres

Many genetic and environmental factors are involved in the development and progression of diabetic kidney disease (DKD), and its pathology shows various characteristics. Animal models of DKD play an important role in elucidating its pathogenesis and developing new therapies. In this study, …

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Effects of Ovariectomy on Kidney Injury in SDT Fatty Rats

Kana Watanabe, Yasuka Saigo, Tomohiko Sasase, Kinuko Uno et autres

Postmenopausal women are at a higher risk of developing diabetes, and estrogen can lower blood glucose levels. The purpose of this study was to investigate the effect of ovariectomy (OVX) on the pathology of diabetic nephropathy. Female SD rats and SDT fatty …

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Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice Mimic the Key Transcriptomic Signatures Observed in Humans

Tatsuya Ishigure, Tomohiko Sasase, Masahiko Tohma, Kosuke Uno et autres

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption or a secondary cause of hepatic steatosis. The prevalence of NAFLD is increasing worldwide and its …

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Prophylactic Pattern Scanning Laser Retinal Photocoagulation for Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats: Preliminary Experimental Results

Rina Takagi, Yoshiaki Tanaka, Tetsuya Hasegawa, Masami Shinohara et autres

The number of diabetic patients worldwide is increasing rapidly. Prevention of diabetic reti-nopathy (DR), a leading cause of blindness, is a serious issue. We examined the effects of prophy-lactic pattern scanning laser retinal photocoagulation on DR development in 16 Spontaneously Diabetic Torii …

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