Houling Zhao

An interpretable multimodal biomechanical–radiological model for predicting fixation failure in osteoporotic hip fractures: A retrospective cohort study

Hongfei Li, Houling Zhao

This study aimed to develop and validate a multimodal prediction model integrating biomechanical and radiological variables to predict internal fixation failure in osteoporotic hip fractures, enabling individualized risk assessment and perioperative decision-making. Patients with osteoporotic hip fractures undergoing internal fixation between March …

cn (code pays fourni par la source)

CLCF1 Exercise-induced Myokine Protocol for Investigating RANKL/OPG Bone Protection Mechanisms in Postmenopausal Osteoporosis

Houling Zhao, Hongfei Li, Yanbin Sun

Recent studies have identified cardiotrophin-like cytokine factor 1 (CLCF1) as an exercise-induced "youth molecule" that mediates musculoskeletal benefits, but declines with age. This protocol describes a systematic approach to investigate CLCF1's regulatory role in exercise-mediated bone protection via immune-bone crosstalk mechanisms. The …

cn (code pays fourni par la source)

Development of a Predictive Model for Kummell's Disease

Yiliang Song, Houling Zhao, Shisheng Liu, Qi Liu et autres

BACKGROUND: Kümmell's disease (KD) is a recognized complication of osteoporotic thoracolumbar vertebral compression fractures (OVCFs), but the risk factors for progression from OVCFs to KD remain unclear. METHODS: This retrospective study included 104 patients with OVCFs from a tertiary hospital between January …

cn (code pays fourni par la source)

Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat

Houling Zhao, Xi Wang, Shuheng Liu, Qingguo Zhang

BACKGROUND: Spinal cord injury (SCI) is a life-threatening traumatic disorder. Paeonol has been confirmed to be involved in a variety of diseases. The purpose of this study is to investigate the role of paeonol on SCI progression. METHODS: Sprague Dawley (SD) rat …

cn (code pays fourni par la source)

[Expression of Wnt5a in dorsal root ganglia in rat model of chronic compression of dorsal root ganglia].

Zhenhao Cao, Yunhu Tian, Lulu Ma, Houling Zhao

OBJECTIVE: To investigate the role of Wnt5a in the mechanism of radiculopathy and the relation between Wnt5a and tumor necrosis factor α (TNF-α) by observing the change of the expression of Wnt5a in the rat model of chronic compression of dorsal root …

cn (code pays fourni par la source)

Structural basis of valmerins as dual inhibitors of GSK3β/CDK5

Xiaolong Li, Xiaowei Wang, Zibin Tian, Houling Zhao et autres

cn (code pays fourni par la source)