Fabien Crauste

Cell trajectory inference based on schrödinger problem and a mechanistic model of stochastic gene expression

Clémence Fournié, Elias Ventre, Ulysse Herbach, Aymeric Baradat et autres

Cellular differentiation is the biological process that leads a cell to opt for a particular cellular identity. Recently, single-cell RNA sequencing has enabled the simultaneous measurement of gene expression levels at specific times for a large number of individual cells and a …

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Global stability and periodicity in a delay differential model

Mostafa Adimy, Fabien Crauste, Anatoli F. Ivanov, Laurent Pujo-Menjouet

International audience

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Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short range diffusive process

Thi Nhu Thao Nguyen, Catherine Koering, Elodie Vallin, Sandrine Giraud et autres

Abstract Neuroblastomas are heterogeneous pediatric tumors of the sympathetic nervous system for which treatments are still limited. Fundamental and applied approaches have been enabled thanks to the generation of patient-derived tumoroids (PDTs), ex vivo 3D structures used as avatars of the original …

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In silico modelling of CD8 T cell immune response links genetic regulation to population dynamics

Thi Nhu Thao Nguyen, Madge Martin, Christophe Arpin, Samuel Bernard et autres

International audience

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New pharmacodynamic parameters linked with ibrutinib responses in chronic lymphocytic leukemia: Prospective study in real-world patients and mathematical modeling

Sarah Cadot, Chloé Audebert, Charlotte Dion, S. Ken et autres

BACKGROUND: One of the first clinical observations of ibrutinib activity in the treatment of chronic lymphocytic leukemia (CLL) is a rapid decline in lymph nodes size. This phenomenon is accompanied by an hyperlymphocytosis, either transient or prolonged, which is associated with distinct …

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Stochastic modeling of a gene regulatory network driving B cell development in germinal centers

Alexey Koshkin, Ulysse Herbach, María Rodríguez Martínez, Olivier Gandrillon et autres

Germinal centers (GCs) are the key histological structures of the adaptive immune system, responsible for the development and selection of B cells producing high-affinity antibodies against antigens. Due to their level of complexity, unexpected malfunctioning may lead to a range of pathologies, …

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Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions

Shaoying Wang, Margaux Prieux, Simon de Bernard, M. Dubois et autres

in the presence or absence of exogenous IL-2 (ex-IL-2). We assessed memory differentiation by transferring these cells into virus-infected mice. Both conditions generated CD8 T cells that participate in the ongoing response and gave rise to similar memory cells. Nevertheless, when transferred …

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In silico modelling of CD8 T cell immune response links genetic regulation to population dynamics

Thi Nhu Thao Nguyen, Madge Martin, Christophe Arpin, Samuel Bernard et autres

Abstract The CD8 T cell immune response operates at multiple temporal and spatial scales, including all the early complex biochemical and biomechanical processes, up to long term cell population behavior. In order to model this response, we devised a multiscale agent-based approach …

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Simuscale: un outil pour la simulation multi-echelles de populations cellulaires

Samuel Bernard, Fabien Crauste, Olivier Gandrillon, Carole Knibbe et autres

Simuscale is a multiscale, individual-based modelling platform for performingnumerical simulations of heterogeneous populations of individual cells evolvingin time and interacting physically and biochemically. Models are described attwo levels: cellular level and population level. The cellular level describesthe dynamics of single cells, as …

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Stochastic modeling of a gene regulatory network driving B cell development in germinal centers

Alexey Koshkin, Ulysse Herbach, María Rodríguez Martínez, Olivier Gandrillon et autres

Abstract Germinal centers (GCs) are the key histological structures of the adaptive immune system, responsible for the development and selection of B cells producing high-affinity antibodies against antigens. Due to their level of complexity, unexpected malfunctioning may lead to a range of …

fr, ch (code pays fourni par la source)

Exogenous IL-2 Delays the Generation of Memory Precursor Cells and is Essential for the Generation of Memory Cells with Increased Effector Functions

Shaoying Wang, Margaux Prieux, Simon de Bernard, M. Dubois et autres

fr, cn (code pays fourni par la source)

A multi-scale model for CD8+ T cell immune response

Fabien Crauste, Olivier Gandrillon, Madge Martin, Thi Nhu Thao Nguyen et autres

International audience

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