Nikola Hadzi‐Petrushev

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko I. Mladenov et autres

Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges. Reactive oxygen species (ROS) play …

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Supplemental material for "Using Visual Cortex Knowledge to Scaffold Artificial Neural Network Concepts"

Nikola Hadzi‐Petrushev, Mitko I. Mladenov, Radoslav Stojchevski, Dimiter Bogdanov Avtanski

This deposit contains the supplemental material for the article "Using Visual Cortex Knowledge to Scaffold Artificial Neural Network Concepts" (Hadzi-Petrushev et al., Advances in Physiology Education). It includes the pre- and post-session questionnaire and the anonymized raw response data from a voluntary …

Supplemental material for "Using Visual Cortex Knowledge to Scaffold Artificial Neural Network Concepts"

Nikola Hadzi‐Petrushev, Mitko I. Mladenov, Radoslav Stojchevski, Dimiter Bogdanov Avtanski

This deposit contains the supplemental material for the article "Using Visual Cortex Knowledge to Scaffold Artificial Neural Network Concepts" (Hadzi-Petrushev et al., Advances in Physiology Education). It includes the pre- and post-session questionnaire and the anonymized raw response data from a voluntary …

EMT-Related Gene Expression in MCF-7 Cells Treated with Monocarbonyl Analogs of Curcumin C66 and B2BrBC Following EMT Induction – RT-qPCR Array Dataset

Radoslav Stojchevski, Sara Velichkovikj, Jane Bogdanov, Katerina Dragarska et autres

Monocarbonyl analogs of curcumin (MACs), C66 [(2E,6E)-2,6-bis[(2-trifluoromethyl)benzylidene]cyclohexanone] and B2BrBC [(2E,6E)-2,6-bis(2-bromobenzylidene)cyclohexanone], were synthesized at the Institute of Chemistry, Ss. Cyril and Methodius University in Skopje, North Macedonia, following the previously published method (DOI: 10.17632/vdgz7pk6vh.1). MCF-7 human breast cancer cells (ATCC, Manassas, VA, USA; …

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EMT-Related Gene Expression in MCF-7 Cells Treated with Monocarbonyl Analogs of Curcumin C66 and B2BrBC Following EMT Induction – RT-qPCR Array Dataset

Radoslav Stojchevski, Sara Velichkovikj, Jane Bogdanov, Katerina Dragarska et autres

Monocarbonyl analogs of curcumin (MACs), C66 [(2E,6E)-2,6-bis[(2-trifluoromethyl)benzylidene]cyclohexanone] and B2BrBC [(2E,6E)-2,6-bis(2-bromobenzylidene)cyclohexanone], were synthesized at the Institute of Chemistry, Ss. Cyril and Methodius University in Skopje, North Macedonia, following the previously published method (DOI: 10.17632/vdgz7pk6vh.1). MCF-7 human breast cancer cells (ATCC, Manassas, VA, USA; …

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EMT-Related Gene Expression in MCF-7 Cells Treated with Monocarbonyl Analogs of Curcumin C66 and B2BrBC Following EMT Induction – RT-qPCR Array Dataset

Radoslav Stojchevski, Sara Velichkovikj, Jane Bogdanov, Katerina Dragarska et autres

Monocarbonyl analogs of curcumin (MACs), C66 [(2E,6E)-2,6-bis[(2-trifluoromethyl)benzylidene]cyclohexanone] and B2BrBC [(2E,6E)-2,6-bis(2-bromobenzylidene)cyclohexanone], were synthesized at the Institute of Chemistry, Ss. Cyril and Methodius University in Skopje, Macedonia, following the previously published method (DOI: 10.17632/vdgz7pk6vh.1). MCF-7 human breast cancer cells (ATCC, Manassas, VA, USA; Cat. …

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Assessment of the anticancer and antimetastatic effects of monocarbonyl analogs of curcumin, C66 and B2BrBC, in breast cancer cells

Radoslav Stojchevski, Sara Velichkovikj, Jane B. Bogdanov, Katerina Dragarska et autres

BACKGROUND: Curcumin, a natural compound found in turmeric (Curcuma longa), demonstrates anticancer properties; however, it is characterized by poor bioavailability and stability. This study investigates the stability, antioxidant activity, and anticancer effects of two monocarbonyl analogs of curcumin (MACs), C66 and B2BrBC, …

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Assessment of the anticancer and antimetastatic effects of monocarbonyl analogs of curcumin, C66 and B2BrBC, in breast cancer cells

Radoslav Stojchevski, Sara Velichkovikj, Jane Bogdanov, Katerina Dragarska et autres

Abstract Background Curcumin, a natural compound found in turmeric (Curcuma longa), demonstrates anticancer properties; however, it is characterized by poor bioavailability and stability. This study investigates the stability, antioxidant activity, and anticancer effects of two monocarbonyl analogs of curcumin (MACs), C66 and …

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Additional file 1 of Assessment of the anticancer and antimetastatic effects of monocarbonyl analogs of curcumin, C66 and B2BrBC, in breast cancer cells

Radoslav Stojchevski, Sara Velichkovikj, Jane B. Bogdanov, Katerina Dragarska et autres

Supplementary Material 1

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Additional file 1 of Assessment of the anticancer and antimetastatic effects of monocarbonyl analogs of curcumin, C66 and B2BrBC, in breast cancer cells

Radoslav Stojchevski, Sara Velichkovikj, Jane B. Bogdanov, Katerina Dragarska et autres

Supplementary Material 1

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Assessment of the anticancer and antimetastatic effects of monocarbonyl analogs of curcumin, C66 and B2BrBC, in breast cancer cells

Radoslav Stojchevski, Sara Velichkovikj, Jane Bogdanov, Katerina Dragarska et autres

Abstract Background Curcumin, a natural compound found in turmeric (Curcuma longa), demonstrates anticancer properties; however, it is characterized by poor bioavailability and stability. This study investigates the stability, antioxidant activity, and anticancer effects of two monocarbonyl analogs of curcumin (MACs), C66 and …

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AI-Guided Discovery of Oncogenic Signaling Crosstalk in Tumor Progression and Drug Resistance

Edward Sutanto, Rinni Sutanto, Sara Velichkovikj, Nikola Hadzi‐Petrushev et autres

The rapid growth and accessibility of artificial intelligence (AI) and machine learning (ML) have opened many avenues to revolutionize biomedical research, particularly in oncogenesis. Oncogenesis is a hallmark process in the development of cancer, involving the amplification of proto-oncogenes and the subsequent …

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