Aleksandar Eftimov

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko I. Mladenov et autres

Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges. Reactive oxygen species (ROS) play …

mk, us (code pays fourni par la source)

Cytokines in Autoimmune Diseases: Pathophysiological Roles and Therapeutic Targeting

Aleksandar Eftimov, Dragica Zendelovska, Kristina Pavlovska, Emilija Atanasovska et autres

Cytokines are critical intermediaries of immune and inflammatory responses and present a central role in the pathogenesis of numerous rare diseases. Dysregulated cytokine production and signaling contribute to disease onset, progression, and clinical heterogeneity, particularly in autoinflammatory, autoimmune, genetic, and neurodegenerative disorders. …

mk (code pays fourni par la source)

PD-L1 Expression as a Predictor of Time to Progression in Metastatic Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Retrospective Single-Center Study

Marija Simonovska, Jasmina Djundeva, Bojana Petreska Kapsarov, Julijana Stefanoska et autres

Background/Objectives: Programmed death-ligand 1 (PD-L1) expression is commonly used as a predictive biomarker in metastatic non-small cell lung cancer (NSCLC); however, its clinical utility in real-world settings remains uncertain. This study evaluated the association between PD-L1 expression and treatment outcomes in patients …

rs, at, mk (code pays fourni par la source)

PON1 (Paraoxonase 1) Q192R Gene Polymorphism in North Macedonian Population with Confirmed Coronary Artery Disease

Katerina Krsteva Jakimovska, Marija Vavlukis, Aleksandar Eftimov, S. Topuzovska

Abstract Aim This study aims to examine the association between the prevalence of Q192R polymorphism of PON1 gene and the occurrence of atherosclerosis and coronary artery disease in patients in Republic of North Macedonia. Method This cross-sectional study includes subjects undergoing percutaneous …

mk, at (code pays fourni par la source)

Genetic Alteration Profiling in North Macedonian Lung Cancer Patients

Aleksandar Eftimov, Rubens Jovanović, Slavica Kostadinova-Kunovska, Magdalena Bogdanovska Todorovska et autres

Background/Objectives: Late diagnosis and inefficient treatment regimens lead to poor prognosis, with a low 5-year survival rate for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). New targeted therapeutic agents can be developed and introduced only by first discovering new …

mk, al, at (code pays fourni par la source)

Genetic Profiling of 717 Colorectal Cancer Patients North Macedonian Study

Aleksandar Eftimov

Colorectal Cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cancer death worldwide.

mk (code pays fourni par la source)

Genetic Alterations Profiling in North Macedonian Lung Cancer Patients

Aleksandar Eftimov

Late diagnosis and inapropriately efficient treatment regimens of lung cancers lead to poor prognosis with 5-year survival rate of 22% for lung cancers in general (Non-Small Cell Lung Cancer (NSCLC) 26 and Small Cell Lung Carcinoma (SCLC) 7).

mk (code pays fourni par la source)

Translon: a single term for translated regions

Michał I. Świrski, Jack A. S. Tierney, M. Mar Albà, Dmitry E. Andreev et autres

pl, gb, ie, es, ru, us, ch, it, ca, de, tw, sg, fr, il, in, au, jp, be, lu, se, cz, nl, sk, hr, pt (code pays fourni par la source)

The Degree of Fibrous Stroma in Pancreatic Ductal Adenocarcinoma Does Not Serve as A Reliable Marker for Survival: A Case Study

N. E, Popova Jovanovska R, Мери Трајковска, Dimitrinka Nikolova et autres

The fibrous stroma (FS) in pancreatic ductal adenocarcinoma develops due to chronic injury during tumor invasion, yet emerging evidence indicates its crucial role in tumor invasion. Aims:This study aims to assess the fibrous stroma percentage (FSP) in pancreatic ductal adenocarcinoma (PDAC) tissue …

Interplay between lymphocyte subpopulation, inflammatory cytokines and their correlation with oxidative stress parameters in COVID-19

Marija Petruševska, Dragica Zendelovska, Emilija Atanasovska, Katerina Spasovska et autres

Our objective was to investigate the inflammatory and oxidative stress markers in patients with moderate and severe form of COVID-19. In addition, we show the correlation between changes in lymphocyte subsets and markers of oxidative stress as a tool for patient classification. …

mk (code pays fourni par la source)

Genetic alterations landscape of lung cancer patients and their therapeutic value: an overview

Milka Ljoncheva, Aleksandar Eftimov

Lung cancer treatmentLate diagnosis and inefficient treatment lead to poor prognosis for most of the lung cancer patients.Improvement of the survival rate and quality of life requires establishment of efficient treatments through gaining comprehensive knowledge of the prevalence, incidence and clinical importance …

si, mk (code pays fourni par la source)

Fibrosis in pancreatic adenocarcinoma: case study

Emilija Nikolovska Trpchevska, Rozalinda Popova Jovanovska, Мери Трајковска, D. Nikolova et autres

mk (code pays fourni par la source)