Nithya Ramesh

Galectin-3 is dispensable for thoracic aortic aneurysmal formation and rupture in mice

Nithya Ramesh, Edward F. Downey, Sudhakar Kanumuri, Zhenguo Liu et autres

Thoracic aortic aneurysm (TAA) development involves disruption of extracellular matrix structural proteins such as collagen and elastin. An increased level of Galectin-3 (Gal-3), a β-galactoside-binding lectin, was reported in ascending aortic aneurysmal patients. To examine the role of Gal-3 on TAA formation …

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Impact of iron deficiency anemia on outcomes in postpartum hemorrhage: Insights from a national inpatient sample analysis

Kalaivani Babu, Srinishant Rajarajan, Nithya Ramesh, Sruthi Priyavadhana Ramanan et autres

Abstract Background: Postpartum hemorrhage (PPH) is a leading contributor to maternal morbidity and mortality worldwide. Iron deficiency anemia (IDA), a common comorbidity during pregnancy, can impair hemostatic reserve and may worsen PPH-related outcomes. Despite its clinical significance, anemia remains underdiagnosed and undertreated …

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Impact of protein-energy malnutrition on in-hospital outcomes in patients undergoing bone marrow transplantation: Insights from a national inpatient sample

Srinishant Rajarajan, Kalaivani Babu, Kriti Dhamija, Shivani Modi et autres

Abstract Background: Protein-energy malnutrition (PEM) is a known contributor to adverse clinical outcomes, particularly in immunocompromised populations. Its role in patients undergoing bone marrow transplantation (BMT) remains understudied. Objective: To evaluate the prevalence of PEM among hospitalized BMT patients and assess its …

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Developing a WHO African Region mOral Health Curriculum for Community Health Workers

Brittany Anne Seymour, Donna M. Hackley, Miriam Wamotho Muriithi, Danielle Burgess et autres

Background: Training allied health professionals in oral health promotion and disease prevention, and integrated into noncommunicable disease (NCD) management, has been shown to improve access to essential oral health services. Oral diseases in the WHO African region are a significant public health …

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Redefining livability through 15-minute neighbourhoods in Bengaluru: an approach to enhance the quality of life through sustainable mobility

Pravalika Sarvadevabhatla, Nithya Ramesh, Arundhati Hakhu

Rapid urbanization in India has strained infrastructure, mobility, and public spaces, reducing urban livability. By 2050, over 800 million people are expected to live in Indian cities, worsening these challenges due to poor planning, outdated design standards, and capacity constraints. Cities like …

Comparative efficacy of idecabtagene vicleucel and ciltacabtagene autoleucel in relapsed/refractory multiple myeloma: Real-world analysis of overall survival and time to next treatment.

Eshan Khan, Rimal Ilyas, Nithya Ramesh, Prerna Mewawalla et autres

e19532 Background: Relapsed/ refractory multiple myeloma (RRMM) is a challenging disease to manage with limited treatment options. Chimeric antigen receptor T-cell (CAR-T) therapies, idecabtagene vicleucel (IC) and ciltacabtagene autoleucel (CC) are approved for overlapping indications in RRMM patients (pts), but comparative real-world …

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Impact of graft-versus-host disease on mortality, length of stay, and hospitalization costs in bone marrow transplant patients: A retrospective analysis using the 2021 NIS database.

Srinishant Rajarajan, Kalaivani Babu, Charmi Bhanushali, Jayalekshmi Jayakumar et autres

e18554 Background: Graft-versus-host disease (GVHD) is a significant complication of bone marrow transplantation (BMT), influencing patient outcomes, length of stay (LOS), and hospitalization costs. This study evaluates the prevalence of GVHD in hospitalized BMT patients and its impact on outcomes using the …

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The paradoxical impact of depression on mortality, length of stay, and hospitalization charges in patients with prostate and bladder cancer: Using the 2021 NIS database.

Srinishant Rajarajan, Kalaivani Babu, Maryam Bibi, Raj N. Shah et autres

e17148 Background: Depression is a prevalent comorbidity in patients with cancer, potentially influencing treatment outcomes. This study evaluates the association of depression with mortality, length of stay (LOS), and hospitalisation charges (TOTCHG) among patients with prostate cancer and bladder cancer. Methods: We …

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Abstract Tu0069: Smooth Muscle Cell Specific Lysl Oxidase Deficiency Accelerates Aortic Stiffness in Mice

Nithya Ramesh, Edward F. Downey, Venkateswaran Subramanian

Background and Objective: Aortic stiffness is a significant risk factor for cardiovascular diseases like hypertension and atherosclerosis. Vascular smooth muscle cells (SMCs) play a crucial role in maintaining aortic structural integrity, and increased SMC stiffness and extracellular matrix deposition contribute to aortic …

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EPIDEMIOLOGY, CLINICAL OUTCOMES, AND DISPARITIES IN PENILE CANCER: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE - 2021

Srinishant Rajarajan, K. A. Babu, Asmi Chattaraj, Nithya Ramesh et autres

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HOSPITAL OUTCOMES AND HEALTHCARE BURDEN OF TESTICULAR CANCER: A RETROSPECTIVE ANALYSIS OF THE 2024 NATIONAL INPATIENT SAMPLE

Srinishant Rajarajan, Kalaivani Babu, Sruthi Priyavadhana Ramanan, Nithya Ramesh et autres

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The Paradoxical Role of Depression in Mortality, Hospitalisation, and Economic Burden Among Bone Marrow Transplantation Patients - Using the National Inpatient Sample (NIS) - 2021

Srinishant Rajarajan, Kalaivani Babu, Jayalekshmi Jayakumar, Nithya Ramesh et autres

Introduction Bone marrow transplantation (BMT) is a critical treatment for haematological malignancies, yet patients undergoing BMT often face significant psychological comorbidities, including depression. Depression is known to influence treatment outcomes in various medical conditions, but its role in patients undergoing BMT is …

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