Impact of graft-versus-host disease on mortality, length of stay, and hospitalization costs in bone marrow transplant patients: A retrospective analysis using the 2021 NIS database.
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
e18554 Background: Graft-versus-host disease (GVHD) is a significant complication of bone marrow transplantation (BMT), influencing patient outcomes, length of stay (LOS), and hospitalization costs. This study evaluates the prevalence of GVHD in hospitalized BMT patients and its impact on outcomes using the 2021 National Inpatient Sample (NIS) database. Methods: We conducted a retrospective analysis of the NIS 2021 dataset. Patients who underwent BMT and patient’s who developed GVHD were identified using the appropriate ICD-10 codes. Survey-weighted descriptive statistics were used to analyze patient demographics, mortality rates, LOS, and total hospitalization charges (TOTCHG). Multivariable logistic and linear regression models evaluated GVHD’s impact on outcomes, adjusting for age, sex, race, income quartiles, Charlson comorbidity index (CCI), hospital region, teaching status, and bed size. The top principal diagnoses were ranked by weighted counts. Results: A total of 20,165 weighted BMT hospitalizations were analyzed, of which 10.9% (95% CI: 9.8%-12.1%) were associated with GVHD. GVHD patients had a significantly higher mortality rate compared to non-GVHD patients (6.4% vs. 4.5%, p=0.04), longer LOS (10.7 vs. 7.2 days, p<0.001) and GVHD patients had significantly higher mean hospitalization charges ($235,485 vs. $113,706). Adjusted regression showed GVHD was associated with a 50% higher odds of mortality (aOR: 1.50, 95% CI: 1.03-2.31, p=0.031), 3.3 additional hospitalization days (95% CI: 1.70-4.87, p<0.001), and $112,376 higher total charges (95% CI: $54,212-$170,539, p<0.001). Significant adjusted predictors of mortality included age (OR = 1.01, p = 0.009) and Charlson Comorbidity Index (OR = 1.47, p < 0.001). Length of stay was significantly influenced by CCI (0.51 days, p = 0.022), and teaching hospital status (1.76 days, p < 0.001). Hospital charges were significantly higher with CCI ($13,646.94, p = 0.023), and at teaching hospitals ($45,054.57, p < 0.001). The most common primary diagnoses among BMT patients with GVHD included septicemia (650 cases), pneumonia (202 cases), acute kidney failure (320 patients) and COVID-19 (130 cases). Conclusions: GVHD significantly exacerbates the clinical and economic burden of BMT, leading to increased mortality, LOS, and healthcare costs. Age, Charlson Comorbidity Index, and teaching hospital status were also significant predictors of mortality, length of stay, and hospital charges. The most common primary diagnoses among GVHD patients included septicemia, pneumonia, acute kidney failure, and COVID-19, underscoring the complexity and resource-intensive care required for this population. These findings emphasize the need to focus on early detection strategies and innovative treatment modalities to mitigate the impact of GVHD in BMT patients.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of graft-versus-host disease on mortality, length of stay, and hospitalization costs in bone marrow transplant patients: A retrospective analysis using the 2021 NIS database.
- Date Crossref
- 01/06/2025
- Éditeur
- American Society of Clinical Oncology (ASCO)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Allegheny General Hospital pays non établi dans la noticeÉtablissement de santé
-
Saint Vincent Hospital pays non établi dans la noticeÉtablissement de santé
-
Brooklyn Hospital Center pays non établi dans la noticeÉtablissement de santé
-
Wichita State University pays non établi dans la noticeUniversité ou école supérieure
-
University of Oklahoma Health Sciences Center pays non établi dans la noticeÉtablissement de santé
-
Allegheny Health Network pays non établi dans la noticeÉtablissement de santé
-
University of Pittsburgh Medical Center Internal Medicine pays non établi dans la noticeÉtablissement de santé
-
Mercy Catholic Medical Center pays non établi dans la noticeÉtablissement de santé
-
Henry Ford Allegiance Health pays non établi dans la noticeÉtablissement de santé
-
The University of Texas MD Anderson Cancer Center pays non établi dans la noticeÉtablissement de santé
-
Kansas University School of Medicine - Wichita pays non établi dans la noticeUniversité ou école supérieure
Allegheny General Hospital, Saint Vincent Hospital et Brooklyn Hospital Center, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.