Accès ouvert
2026
article
OpenAlex
Petko Nedyalkov Denev, Desislava Georgieva Teneva, Manol Hristov Ognyanov, Mariya Pimpilova et autres
This study investigates subcritical water extraction (SWE) as an alternative to hydroalcoholic extraction for the production of Echinacea purpurea root extracts standardized to hydroxycinnamic acids (cichoric and caftaric acids). Extractions were performed at 100 °C, 125 °C, 150 °C, and 170 °C …
bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Radostina G. Kalinova, Ivaylo V. Dimitrov, Yana E. Ilieva, Dimitar Borisov Iliev et autres
Nanotechnology offers alternative approaches to the discovery of anticancer drugs. Hydrophobic bioactive components can be included in the cores of amphiphilic nanocarriers, which leads to the formation of a water-dispersible product with improved bioavailability, facilitated excretion, and reduced systemic toxicity in the …
bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mihaela Stoyanova, Vera Gledacheva, Miglena Milusheva, Mina Mihaylova Todorova et autres
Human pathogenic fungi are the source of various illnesses, including invasive, cutaneous, and mucosal infections. One promising solution is using nanoparticles (NPs) as an antifungal agent. The current study aims to assess the antimicrobial and antifungal effects of drug-loaded silver nanoparticles (AgNPs) …
bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Penyo Ivanov, Dessislava Staneva, Milena Georgieva, George A. Miloshev
The comet assay is a valuable technique for assessing cellular DNA damage due to intrinsic and environmental factors, particularly in studies of genotoxicity and mutagenesis. However, its broader application is limited by the need for fluorescent staining, the requirement for expensive fluorescent …
bg
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Accès ouvert
2025
article
OpenAlex
Milena Georgieva, Bela Vasileva, Penyo Ivanov, Kamelia Hristova‐Panusheva et autres
Skin ageing is a complex biological process influenced by cellular senescence, oxidative stress, and extracellular matrix degradation. Emerging evidence suggests that plant-derived bioactive compounds and extracellular vesicles (EVs) play a crucial role in modulating cellular homeostasis, promoting tissue regeneration, and counteracting age-related …
bg
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Accès ouvert
2025
article
OpenAlex
Mihaela Stoyanova, Miglena Milusheva, Vera Gledacheva, Mina Mihaylova Todorova et autres
Background/Objectives: Mebeverine hydrochloride (MBH) is an antispasmodic agent used to regulate bowel movements and relax intestinal smooth muscle, but its application is limited by specific side effects; therefore, this study investigates the effects of previously synthesized MBH-loaded silver nanoparticles (AgNPs) on smooth …
bg
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Accès ouvert
2025
article
OpenAlex
M Milev, Boris Roglev, Maria Kondeva Rogleva, Milena Georgieva et autres
(Poly)phenols are plant-derived food bioactives abundantly present in human diet. They exert positive effects on various aspects of human health and in particular in reducing the risk of chronic non-communicable diseases. Dietary (poly)phenols have been reported to improve vascular function, blood lipids, …
mk, pt, bg
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Accès ouvert
2025
article
OpenAlex
George A. Miloshev, Penyo Ivanov, Bela Vasileva, Milena Georgieva
Ageing comprises a cascade of processes that are inherent in all living creatures. There are fourteen general hallmarks of cellular ageing, the majority of which occur at a molecular level. A significant disturbance in the regulation of genome activity is commonly observed …
bg
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Accès ouvert
2025
article
OpenAlex
Mihaela Stoyanova, Miglena Milusheva, Milena Georgieva, Penyo Ivanov et autres
Background: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder with a complex pathogenesis that necessitates innovative therapeutic approaches for effective management. Among the commonly used treatments, mebeverine (MBH), an antispasmodic, is widely prescribed to alleviate IBS symptoms. However, challenges in delivering …
bg, ir
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Accès ouvert
2024
article
OpenAlex
Bela Vasileva, Natalia A. Krasteva, Kamelia Hristova‐Panusheva, Penyo Ivanov et autres
The escalating elderly population worldwide has prompted a surge of interest in longevity medicine. Its goal is to interfere with the speed of ageing by slowing it down or even reversing its accompanying effects. As a field, it is rapidly growing and …
bg
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Accès ouvert
2024
article
OpenAlex
Boryana Trusheva, Hristo Petkov, Ralitsa Chimshirova, Milena Popova et autres
Natural deep eutectic solvents (NADESs) have been considered promising to replace traditional volatile and toxic organic solvents for the extraction of biologically active substances from natural sources. This work applied an efficient and ethanol-exclusion strategy for extraction of phenolic compounds from poplar …
bg
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Accès ouvert
2023
article
OpenAlex
Dessislava Staneva, Neli Dimitrova, Borislav Nikolov Popov, Albena Alexandrova et autres
Ionizing radiation (IR) and reactive oxygen species (ROS)-induced oxidative stress can cause damage to cellular biomolecules, including DNA, proteins, and lipids. These harmful effects can compromise essential cellular functions and significantly raise the risk of metabolic dysfunction, accumulation of harmful mutations, genome …
bg
(code pays fourni par la source)