Synthesis, Cytotoxic and Genotoxic Evaluation of Drug-Loaded Silver Nanoparticles with Mebeverine and Its Analog
Rattachement africain : bg, ir. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder with a complex pathogenesis that necessitates innovative therapeutic approaches for effective management. Among the commonly used treatments, mebeverine (MBH), an antispasmodic, is widely prescribed to alleviate IBS symptoms. However, challenges in delivering the drug precisely to the colonic region often hinder its therapeutic effectiveness. To address this limitation, silver nanoparticles (AgNPs) have emerged as promising drug delivery systems, offering unique physicochemical properties that can enhance the precision and efficacy of IBS treatments. Objectives: This study aimed to synthesize AgNPs as drug delivery vehicles for MBH and a previously reported analog. The research focused on evaluating the cytotoxic and genotoxic effects of the AgNPs and forecasting their possibly harmful effects on future sustainable development. Methods: AgNPs were synthesized using a rapid method and functionalized with MBH and its analog. The nanoparticles were characterized using different techniques. Cytotoxicity and genotoxicity were evaluated in vitro. Additionally, in silico docking analyses were performed to explore their safety profile further. Results: In vitro assays revealed concentration-dependent cytotoxic effects and a lack of genotoxic effects with MBH-loaded AgNPs. A molecular docking simulation was performed to confirm this effect. Conclusions: The study underscores the potential of AgNPs as advanced drug delivery systems for safe and significant therapeutic implications for IBS. Future in vivo and preclinical investigations are essential to validate the safe range of exposure doses and evaluation standards for assessing AgNPs’ safety in targeted and personalized medicine.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Synthesis, Cytotoxic and Genotoxic Evaluation of Drug-Loaded Silver Nanoparticles with Mebeverine and Its Analog
- Date Crossref
- 12/03/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Plovdiv University pays non établi dans la noticeUniversité ou école supérieure
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Medical University Plovdiv pays non établi dans la noticeUniversité ou école supérieure
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Bulgarian Academy of Sciences pays non établi dans la noticeOrganisme public
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Institute of Molecular Biology pays non établi dans la noticeStructure de recherche
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Institute of Biophysics and Biomedical Engineering pays non établi dans la noticeStructure de recherche
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Alzahra University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Chemistry Department of Organic Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Bioorganic Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Laboratory of Molecular Genetics pays non établi dans la noticeStructure de recherche
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University of Plovdiv Department of Analytical Chemistry and Computer Chemistry pays non établi dans la noticeUniversité ou école supérieure
Plovdiv University, Medical University Plovdiv et Bulgarian Academy of Sciences, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.