Wenfang Chen

Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis

Haoran Lv, Guanning Huang, Hongyu Li, Hanzhi Liang et autres

Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), is largely driven by dysregulated macrophage responses. However, the heterogeneity of macrophages hinders the development of targeted therapies for LN. Here, through single-cell analysis and clinical specimen validation, it is found …

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Induction chemotherapy plus camrelizumab followed by concurrent chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma: a single-arm phase II trial

Fang Peng, Jialiang Wu, Huimin Lian, Shaoqing Niu et autres

Concurrent chemoradiotherapy (CCRT) has remained the standard treatment for unresectable locally advanced esophageal squamous cell carcinoma (ESCC), yet survival remains poor. This single-arm, phase II trial aims to evaluate the efficacy and safety of two cycles of induction chemotherapy with camrelizumab followed …

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A Rare Case of Hyperamylasemia With a Rare Cause

Yuwen Tao, Wenfang Chen, Feng Ye

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A Novel Perspective on Tubular C4d Positivity in BK Polyomavirus Nephropathy

Tong Wu, Fangzhou Guo, Shicong Yang, Zeying Jiang et autres

Introduction Tubular basement membrane (TBM) C4d staining has been frequently observed in BK polyomavirus nephropathy (BKPyVN), yet its specificity and clinical implications remain unclear. Methods Biopsy data from 272 patients with BK viruria, including 4 native BKPyVN, 150 allograft BKPyVN and 118 …

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Mutation spectra and genotype‑phenotype analysis of congenital hypothyroidism in a neonatal population

Xiang Huang, Wenfang Chen, Weixi Yuan, Jiayu Tan et autres

Congenital hypothyroidism (CH) is a common neonatal endocrine disorder that is characterized by irreversible neurodevelopmental and growth retardation due to insufficient biosynthesis of thyroid hormones at birth. Determining the causative genetic variants in infants is important for neonatal management. It was aimed …

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Network pharmacology and molecular docking reveal potential mechanisms of ginseng in the treatment of diabetes mellitus-induced erectile dysfunction and asthenospermia

Liming Liu, Yuanfeng Zhang, Jia‐Shu Yang, Wenfang Chen et autres

Diabetes mellitus (DM) is a chronic metabolic disease that predisposes to chronic damage and dysfunction of various organs, including leading to erectile dysfunction (ED) and asthenospermia. Literature suggests that ginseng plays an important role in the treatment and management of DM. Ginseng …

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Application of SVR-Based Model for Compensating Comprehensive Thermal Displacement of Machine Tools

Wei‐Ren Chen, Chun‐Yi Chen, Wenfang Chen, Kai-Jun Hsu et autres

This study develops a detection fixture and method capable of capturing multi-axis thermal errors simultaneously. It can measure thermal errors in the spindle rotation, as well as in the X and Y feed axes, achieving multi-axis synchronous measurement. This approach is more …

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Annexin A1 protects epidermal stem cells against ultraviolet-B irradiation-induced mitochondrial dysfunction

Lingzhi Ge, Wenfang Chen, Fangli Wei

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Mobile health–supported comprehensive intervention model (CIMmH) improved physical fitness of patients with esophageal cancer after esophagectomy: Prospective randomized controlled trial.

Weixiong Yang, Yan Guo, Chuanbao Deng, Shuyu Zhuo et autres

1634 Background: Esophageal cancer (EC) significantly impacts patients’ quality of life (QOL) post-esophagectomy, with malnutrition, reduced physical activity, and psychological distress being common. Our preliminary study indicated that a Mobile Health-Supported Comprehensive Intervention Model (CIMmH) is safe, feasible, and efficacious in improving …

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Enhancing antitumor response by efficiently generating large-scale TCR-T cells targeting a single epitope across multiple cancer antigens

Obed Boadi Amissah, Rajesh Basnet, Wenfang Chen, Jean de Dieu Habimana et autres

cn, Ghana, gb, hk (code pays fourni par la source)

Abstract 5173: TRAIL expression in tumor cells predicts and drives poor response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma

Weixiong Yang, Fang Wang, Jianping Guo, Junchao Cai et autres

Abstract Background: Neoadjuvant PD-1 blockade combined with chemotherapy has shown promising antitumor efficacy in the therapy of esophageal squamous cell carcinoma (ESCC). However, effective biomarkers and potential mechanisms of resistance to this treatment are still unclear. Methods: We prospectively collected pre- and …

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Value of original and modified pathological scoring systems for prognostic prediction in paraffin-embedded donor kidney core biopsy

Jinghong Tan, Huanxi Zhang, Longshan Liu, Jun Li et autres

BACKGROUND: No study has validated, compared and adapted scoring systems for prognosis prediction based on donor kidney core biopsy (CB), with less glomeruli than wedge biopsy. METHODS: A total of 185 donor kidney CB specimens were reviewed using seven scoring systems. The …

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