Yukihiro Hitaka

Renoprotective effects of gut NHE3 inhibitor tenapanor in a rat model of unilateral renal ischemia–reperfusion injury with contralateral nephrectomy

Mitsuhiro Yamaguchi, Yukihiro Hitaka, Shunya Tsuji, Masashi Ogawa et autres

Kidney ischemia-reperfusion (I/R) injury is an unavoidable complication of kidney transplantation that contributes to acute kidney injury (AKI), chronic kidney disease (CKD), and limited long-term graft survival. Elevated serum phosphate has been implicated not only as a consequence of renal dysfunction but …

jp (code pays fourni par la source)

Anti-A Antibody Rebound–Induced Thrombotic Microangiopathy After ABO-Incompatible Kidney Transplantation: A Case Report

Yukihiro Hitaka, Naohito Isoyama, Megumi Tanaka, Yoshimasa Ban et autres

jp (code pays fourni par la source)

Necrotic-cell–activated macrophages drive an ERK–Bcl-xL survival pathway in osteoclasts and confer bisphosphonate resistance

Kazuya Uehara, Keiichi Katō, Shunya Tsuji, Kiminori Yukata et autres

Nontraumatic osteonecrosis of the femoral head (ONFH) is a progressive disorder marked by ischemic necrosis of subchondral bone, often leading to femoral head collapse. Although bisphosphonates effectively target osteoclasts in osteoporosis and show benefit in ONFH animal models, their effectiveness to prevent …

jp (code pays fourni par la source)

Prolonged Delayed Graft Function Without Rejection After High-Risk ABO-Incompatible Living Donor Kidney Transplantation: A Case Report

Yu Okada, Mitsuhiro Yamaguchi, Masashi Ogawa, Hironori Matsushita et autres

jp (code pays fourni par la source)

Extracellular vesicles-derived LncRNA MAFG-AS1 predicts clinical response to pembrolizumab in patients with advanced urothelial carcinoma

Nakanori Fujii, Hiroshi Hirata, Yoshimasa Ban, Shintaro Oka et autres

jp (code pays fourni par la source)

High-Concentration Hydrogen Delivery During Dialysis Using an Innovative Direct Dissolution Technique: In Vivo Kinetics in a Canine Model

Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Hitoshi Uchinoumi et autres

Hydrogen gas (H₂) shows broad therapeutic potential. Hemodialysis, using large dialysate volumes in contact with blood, presents a promising H₂ delivery method. We developed an innovative system generating hydrogen-enriched dialysate, differing from conventional electrolysis. This system directly dissolves H₂ gas into tap …

jp (code pays fourni par la source)

Exploration of predictive factors based on oral and intestinal bacterial flora for treating patients with urothelial carcinoma

Yuichi Matsumoto, Yukihiro Hitaka, Hiroshi Hirata, Yoshiaki Yamamoto et autres

PURPOSE: The role of intestinal flora in carcinogenesis and chemotherapy efficacy has been increasingly studied; however, comparisons between oral and intestinal flora remain limited. Given the oral microbiome's role in systemic inflammation and immune modulation, it may significantly influence cancer progression and …

jp (code pays fourni par la source)

A0870 – Clock gene Bmal1 acts in tumor suppressive in non-muscle invasive bladder cancer and enhance the efficacy of BCG intravesical infusion therapy

Nakanori Fujii, H. Hirata, Yukihiro Hitaka, Keisuke Shimizu et autres

Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma

Takanori Tokunaga, Hiroshi Hirata, Yukihiro Hitaka, Nakanori Fujii et autres

Long noncoding RNAs (lncRNAs) serve pivotal roles in cancer biology. The present study investigated the oncogenic roles of lncRNAs in renal cell carcinoma (RCC) and their potential as prognostic biomarkers. The lncRNA leucine‑rich repeat containing 75 A‑antisense RNA1 (LRRC75A‑AS1) was identified through …

jp (code pays fourni par la source)

Comparative analysis of oncological outcomes between trimodal therapy and radical cystectomy in muscle-invasive bladder cancer utilizing propensity score matching

Keita Kobayashi, Nakanori Fujii, Kosuke Shimizu, Yukihiro Hitaka et autres

BACKGROUND: Bladder preservation therapy for muscle-invasive bladder cancer is reported to yield outcomes comparable to those of radical cystectomy, although it receives a relatively low recommendation grade in Japanese guidelines. This study aims to compare the outcomes of trimodal therapy versus radical …

jp (code pays fourni par la source)

Comparative analysis of oncological outcomes between trimodal therapy and radical cystectomy in muscle-invasive bladder cancer utilizing propensity score matching

Keita Kobayashi, Nakanori Fujii, Kosuke Shimizu, Yukihiro Hitaka et autres

Abstract Purpose: To compare the outcomes of trimodal therapy (TMT) and radical cystectomy (RC) in the treatment of muscle-invasive bladder cancer (MIBC). Methods: Patients treated with either TMT or RC for MIBC at our institution between January 1998 and December 2022 were …

jp (code pays fourni par la source)

#1181 The relationship between renal ischaemia-reperfusion injury and circadian rhythm

Misuhiro Yamaguchi, Yukihiro Hitaka, Kimihiko Nakamura, Toshiya Hiroyoshi et autres

Abstract Background and Aims Kidney disease is a global health problem in which various aetiologies contribute to renal injury and dysfunction. Renal ischaemia-reperfusion injury (IRI) is a condition caused by early oxidative stress due to renal tissue ischaemia and a rapid immune …

jp (code pays fourni par la source)