Kazutoshi Fujita

Impact of baseline renal function on the clinical outcomes and safety of adjuvant nivolumab in high-risk urothelial carcinoma: a multicenter retrospective real-world study

Asuka Sano, Yuya Oishi, Yoshihiro Tsuchiya, Gaku Ishikawa et autres

Abstract Background Adjuvant nivolumab prolongs disease-free survival (DFS) in patients with urothelial carcinoma (UC) after radical surgery; however, evidence in those with reduced baseline renal function is limited. We investigated the impact of baseline creatinine clearance (CCr) on DFS and immune-related adverse …

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Enfortumab vedotin plus pembrolizumab for recurrent metastatic urothelial carcinoma following adjuvant nivolumab

Lan Inoki, Saizo Fujimoto, Mamoru Hashimoto, Yutaka Yamamoto et autres

Adjuvant nivolumab is an established postoperative treatment for high-risk urothelial carcinoma, but evidence for subsequent enfortumab vedotin plus pembrolizumab (EVP) after recurrence is limited. We retrospectively evaluated 17 patients with locally advanced or metastatic urothelial carcinoma who received EVP after recurrence following …

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Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

Saizo Fujimoto, Tsuyoshi Morita, Yutaka Yamamoto, Teruo Inamoto et autres

BACKGROUND: Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone-sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite second-generation androgen receptor antagonist-based doublet therapy. Although triplet …

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Perioperative Outcomes of Salvage Radical Prostatectomy After Radiation Therapy: A Nationwide Analysis Using the National Clinical Database of Japan

Kazutoshi Fujita, Ami Makita, Daisuke Ishii, Hiroyuki Yamamoto et autres

BACKGROUND: Salvage radical prostatectomy (sRP) is a potentially curative treatment for localized recurrence after radiation therapy for prostate cancer; however, nationwide real-world perioperative outcomes remain unclear. METHODS: We conducted a retrospective descriptive study using the Japanese National Clinical Database (NCD). Patients who …

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[ 18 F ] PSMA ‐1007 PET –Based Recurrence Site Distribution and Predictors of Metastatic Disease in Patients With Biochemical Recurrence of Prostate Cancer

Koji Hatano, Tadashi Watabe, Takero Hirata, Masatoshi Konishi et autres

ABSTRACT Objectives Prostate‐specific membrane antigen positron emission tomography (PSMA‐PET) is a sensitive imaging modality for detecting recurrent prostate cancer following definitive local therapy. However, evidence on 18 F‐labeled PSMA tracers in Japanese patients with biochemical recurrence (BCR) remains limited. The aim of …

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Timing-dependent skin toxicity phenotypes during enfortumab vedotin plus pembrolizumab therapy for advanced urothelial carcinoma

Mamoru Hashimoto, Lan Inoki, Yutaka Yamamoto, Wataru Fukuokaya et autres

BACKGROUND: Enfortumab vedotin plus pembrolizumab (EV/Pem) has improved the survival of patients with advanced urothelial carcinoma; however, many patients suffer treatment-related adverse events, particularly skin toxicity. This study aimed to clarify the clinical impact of skin-toxicity timing on treatment outcomes. METHODS: We …

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A Hybrid Retroperitoneal–Transperitoneal Approach for Robot‐Assisted Radical Nephrectomy: A Technical Report of Two Cases

Takayuki Ohzeki, Yuto Mitsuhashi, Lan Inoki, Tsuyoshi Morita et autres

Introduction: Robot-assisted radical nephrectomy (RARN) can be performed using either transperitoneal or retroperitoneal approaches; however, each has inherent limitations, particularly in cases with complex hilar anatomy or post-systemic therapy fibrosis. Case Presentation: Hybrid RARN was performed in two patients with renal cell …

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Prevalence and Associated Factors of Erectile Dysfunction in Japanese Adolescent and Young Adult (AYA) Male Cancer Survivors

K. Miki, Takahito Nakayama, Shingo Toyoda, Mamoru Hashimoto et autres

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Differential impact of host-related factors on survival outcomes between IO+IO and IO+TKI in metastatic renal cell carcinoma: a multicenter retrospective study

Koichi Sugimoto, Shingo Toyoda, Lan Inoki, Keiichiro Mori et autres

BACKGROUND: Immune checkpoint inhibitor (ICI)-based combination therapies, including immune checkpoint inhibitor plus immune checkpoint inhibitor (IO + IO) and immune checkpoint inhibitor plus tyrosine kinase inhibitor (IO + TKI) regimens, have significantly improved outcomes in metastatic renal cell carcinoma (mRCC). However, the …

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GG02-40 EXERCISE INHIBITS PROSTATE CANCER PROGRESSION BY SUPPRESSING ARGINASE1

Toshiki Oka, Koji Hatano, Hiroaki Hase, Masatoshi Konishi et autres

IP77-20 TARGETING EPHA2 REVERSES IMMUNOTHERAPY RESISTANCE IN BASAL/SQUAMOUS BLADDER CANCER VIA CCL5-MEDIATED T-CELL RECRUITMENT

Eisuke Tomiyama, Morgan E. Roberts, Alberto Contreras-Sanz, Igor Moskalev et autres

Treatment strategies for locally advanced and metastatic urothelial carcinoma based on molecular profiles: A Review.

Mamoru Hashimoto, Ken Fukiage, Takafumi Minami, Marco A. De Velasco et autres

Urothelial carcinoma (UC), which includes bladder carcinoma (accounting for 90-95% of cases) and upper urinary tract carcinoma (comprising 5-10%), is one of the most prevalent malignancies worldwide. For several decades, platinum-based chemotherapy has been the primary treatment modality for this disease. However, …

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