Brian R Shiels

A roll of the dice: pathogen–host interaction and the evolution of disease susceptibility

Paul Capewell, Philipp Olias, Brian R Shiels

Abstract The probability that a disease will manifest is highly variable. Susceptibility to disease is influenced by genetic background, environment and lifestyle choices. In this review, we put forward the premise that evolution of disease susceptibility may be partially influenced by the …

gb, ch, de (code pays fourni par la source)

A roll of the dice: pathogen-host interaction and the evolution of disease susceptibility.

Paul Capewell, Philipp Olias, Brian R Shiels

In vivo assessment of buparvaquone resistant Theileria annulata populations: genetic structure, transmission dynamics, drug susceptibility and pharmacokinetics

Selin Hacılarlıoğlu, Hüseyin Bilgin Bilgiç, Cengiz Gökbulut, Serkan Bakırcı et autres

Tropical theileriosis, caused by the protozoan parasite Theileria annulata and transmitted by several species of ixodid ticks of the genus Hyalomma, is an economically important disease of bovines. Concerningly, studies conducted in recent years have shown an increase in the rate of …

tr, fi, gb (code pays fourni par la source)

paraCell: a novel software tool for the interactive analysis and visualization of standard and dual host–parasite single-cell RNA-seq data

Edward Agboraw, William A. Haese-Hill, Franziska Hentzschel, Emma M. Briggs et autres

Advances in sequencing technology have led to a dramatic increase in the number of single-cell transcriptomic datasets. In the field of parasitology, these datasets typically describe the gene expression patterns of a given parasite species at the single-cell level under experimental conditions, …

gb, es, de, fr (code pays fourni par la source)

Upregulation of haematopoetic cell kinase (Hck) activity by a secreted parasite effector protein (Ta9) drives proliferation of Theileria annulata-transformed leukocytes

Shahin Tajeri, Brian R Shiels, Gordon Langsley, Ard Menzo Nijhof

Reversible transformation of bovine leukocytes by the intracellular parasites Theileria annulata and Theileria parva is central to pathogenesis of the diseases they cause, tropical theileriosis and East Coast Fever, respectively. Parasite-dependent constitutive activation of major host transcription factors such as AP-1 (Activating …

de, gb, fr (code pays fourni par la source)

A parasite DNA binding protein with potential to influence disease susceptibility acts as an analogue of mammalian HMGA transcription factors

Zeeshan Durrani, Jane H. Kinnaird, Chew Weng Cheng, Francis Brühlmann et autres

Intracellular pathogens construct their environmental niche, and influence disease susceptibility, by deploying factors that manipulate infected host cell gene expression. Theileria annulata is an important tick-borne parasite of cattle that causes tropical theileriosis. Excellent candidates for modulating host cell gene expression are …

gb, ch, de (code pays fourni par la source)

Arc Rating Variability and Repeatability: Why Does Fabric Arc Rating Vary and Which Value is Correct?

Aasim Atiq, Eduardo Ramirez-Bettoni, Brian R Shiels, Claude Maurice et autres

Variability in arc ratings of fabrics poses challenges for end users, manufacturers and test laboratories. In this paper a test laboratory, a manufacturer, and a large US electric utility partnered and performed repeat tests on fabrics to study variability in arc ratings. …

us, ca (code pays fourni par la source)

Selection of genotypes harbouring mutations in the cytochrome b gene of Theileria annulata is associated with resistance to buparvaquone

Selin Hacılarlıoğlu, Hüseyin Bilgin Bilgiç, Serkan Bakırcı, Andrew Tait et autres

Buparvaquone remains the only effective therapeutic agent for the treatment of tropical theileriosis caused by Theileria annulata. However, an increase in the rate of buparvaquone treatment failures has been observed in recent years, raising the possibility that resistance to this drug is …

tr, gb (code pays fourni par la source)

Novel equi merozoite antigen (ema-1) gene heterogeneity in a geographically isolated Theileria equi population in Croatia

Robert Coultous, Jelena Gotić, Martine McCann, David G. M. Sutton et autres

BACKGROUND: The apicomplexan haemoparasite Theileria equi, a causative agent of equine piroplasmosis, is an established pathogen of significant welfare and economic concern within the Croatian equine population. A previous large surveillance study of T. equi has identified two distinct parasite populations, one …

gb, hr (code pays fourni par la source)

Theileria annulata histone deacetylase 1 (TaHDAC1) initiates schizont to merozoite stage conversion

Shahin Tajeri, Laurence Momeux, Benjamin Saintpierre, Sara Mfarrej et autres

A fungal metabolite, FR235222, specifically inhibits a histone deacetylase of the apicomplexan parasite Toxoplasma gondii and TgHDAC3 has emerged as a key factor regulating developmental stage transition in this species. Here, we exploited FR235222 to ask if changes in histone acetylation regulate …

fr, de, sa, gb, jp (code pays fourni par la source)

Theileria annulata histone deacetylase 1 (TaHDAC1) initiates schizont to merozoite stage conversion

Shahin Tajeri, Laurence Momeux, Benjamin Saintpierre, Sara Mfarrej et autres

Abstract A fungal metabolite, FR235222, specifically inhibits a histone deacetylase of the apicomplexan parasite Toxoplasma gondii and TgHDAC3 has emerged as a key factor regulating developmental stage transition in this species. Here, we exploited FR235222 to ask if changes in histone acetylation …

fr, sa, gb, jp (code pays fourni par la source)

Challenge Accepted: Specialty PPE for Shock and Arc Flash Protection

Hugh Hoagland, Brian R Shiels, Stacy L. Klausing

This paper reviews testing that has been completed on specialty PPE for arc flash and shock protection. Specialty PPE herein covers PPE for hazards other than arc flash which may or may not be arc rated to provide protection from another hazard. …