Armelle Grevot

STP Town Hall Discussion on the Use of Virtual Control Groups in Nonclinical Toxicity Studies

Kirstin Barnhart, Brad N. Bolon, Laura I. Boone, Stacey L. Fossey et autres

The 2025 Town Hall meeting of the Society of Toxicologic Pathology (STP) discussed virtual control groups (VCG) in nonclinical toxicity testing, which are being pursued by multiple organizations to reduce animal use in product development. The current VCG literature infrequently reflects the …

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Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies

Magali Guffroy, Tara Arndt, Erio Barale-Thomas, Susan Bolin et autres

Nonhuman primates (NHPs) have been and remain a highly valuable animal model with an essential role in translational research and pharmaceutical drug development. Based on current regulatory guidelines, the nonclinical safety of novel therapeutics should be evaluated in relevant nonclinical species, which …

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Points to consider regarding the use and implementation of virtual controls in nonclinical general toxicology studies

Xavier Palazzi, Lennart T Anger, Theresa Boulineau, Armelle Grevot et autres

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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

Kenji Namoto, Clara Baader, Vanessa Orsini, Alexandro Landshammer et autres

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Toxicologic Pathology Forum Opinion Piece: Use of Virtual Control Groups in Nonclinical Toxicity Studies: The Anatomic Pathology Perspective

Armelle Grevot, Julie Boisclair, Magali Guffroy, Peter Hall et autres

In the last decade, numerous initiatives have emerged worldwide to reduce the use of animals in drug development, including more recently the introduction of Virtual Control Groups (VCGs) concept for nonclinical toxicity studies. Although replacement of concurrent controls (CCs) by virtual controls …

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Toward implementing virtual control groups in nonclinical safety studies

Emily Golden, David F. Allen, Alexander Amberg, Lennart T. Anger et autres

Historical data from control groups in animal toxicity studies are currently mainly used for comparative purposes to assess validity and robustness of study results. Due to the highly controlled environment in which the studies are performed and the homogeneity of the animal …

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Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf −/− mouse model

Emilie A. Chapeau, Agnieszka Gembarska, Éric Durand, Emeline Mandon et autres

Significance Emergence of resistance to targeted therapy constitutes a limitation to long-term clinical benefits in many instances. To anticipate potential mechanisms of resistance to double minute 2 protein (MDM2) inhibitors, we performed a piggyBac insertional mutagenesis screen in a cohort of allografts …

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Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation

Jens Schümann, Armelle Grevot, David Ledieu, Armin Wolf et autres

Sphingosine-1-phosphate (S1P) lyase is considered as a drug target in autoimmune diseases based on the protective effect of reducing activity of the enzyme in animal models of inflammation. Since S1P lyase deficiency in mice causes a severe, lethal phenotype, it was of …

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Heart Structure-Specific Transcriptomic Atlas Reveals Conserved microRNA-mRNA Interactions

Caterina Vacchi‐Suzzi, Florian Hahne, Philippe Scheubel, Magali Marcellin et autres

MicroRNAs are short non-coding RNAs that regulate gene expression at the post-transcriptional level and play key roles in heart development and cardiovascular diseases. Here, we have characterized the expression and distribution of microRNAs across eight cardiac structures (left and right ventricles, apex, …

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

Martin C. Herzig, Carine Kolly, Elke Persohn, Diethilde J Theil et autres

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), but the underlying pathophysiological mechanisms and the normal function of this large multidomain protein remain speculative. To address the role of this protein in vivo, we generated three different LRRK2 …

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Characterisation of a refined rat model of respiratory infection with Pseudomonas aeruginosa and the effect of ciprofloxacin

Ellena J. Growcott, Alan Coulthard, Richard T. Amison, Elizabeth L. Hardaker et autres

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