Xingshun Xu

Spatial synaptic pruning mechanism of NAC microglia in differential regulation of PTSD- and depression-like behaviors

Mingyue Zhao, Wenyu Tian, Xinyu Hu, Jiajie Dai et autres

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Wdr26 insufficiency causes Skraban-Deardorff syndrome–like neurodevelopmental deficits in mice

Xingyun Xu, Yaohui Zhou, Shiyao Xu, Hongjie Zhou et autres

Skraban-Deardorff syndrome, a rare neurodevelopmental disorder caused by WD repeat domain 26 (WDR26) haploinsufficiency, is characterized by intellectual disability, seizures, autistic-like behaviors, and craniofacial anomalies. Despite its genetic association with variants disrupting the C-terminal to LisH (CTLH) E3 ubiquitin ligase complex, the …

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High-frequency rTMS applied to the right hemisphere promotes aphasia recovery and brain microstructural changes in subacute stroke

Qiwei Yu, Yan Sun, Xiaowen Ju, Kefu Liu et autres

BACKGROUND: The role of the right hemisphere in post-stroke aphasia (PSA) remains one of the key controversies in contemporary neuroscience. While accumulating evidence has demonstrated the clinical potential of repetitive transcranial magnetic stimulation (rTMS) for the management of PSA, consensus regarding optimal …

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Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study

Yutong Zhang, Lulu Sun, Ying Zhao, Zhen Zhang et autres

BACKGROUND: We tested whether inflammation indexed by soluble tumor necrosis factor receptor-1 (sTNFR1) is related to cognitive decline. We examined serum sTNFR1 with cognition in the Health and Retirement Study (HRS) and cerebrospinal fluid (CSF) sTNFR1 with tau pathology and magnetic resonance …

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Targeting Cend1-Atp5f1b interaction rescues mitochondrial dysfunction and ameliorates ischemic brain injury

Hao Li, Yi Yang, Meng Zhang, Eric Guo et autres

Mitochondrial dysfunction is a critical contributor to neuronal damage in acute ischemic stroke (AIS), and targeting mitochondrial function represents a promising therapeutic strategy. This study unveils the pivotal role of Cend1 protein in ischemic stroke and elucidates its underlying mechanisms. Using Cend1 …

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Relative change rate of anti-acetylcholine receptor antibodies concentration Correlates with the recurrence of myasthenia gravis in AChR-Abs-positive patients

Jingluan Tian, Xiaoling Zhou, Feng Zhu, Xinyi Xiao et autres

• A weak relationship between AChR-Abs concentration and MG severity at onset. • RCR of AChR-Abs concentration and MG subtypes was associated with MG recurrence. • Repeated AChR-Abs measurements are valuable for monitoring disease development. Myasthenia gravis (MG) is an autoimmune disease …

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Global, regional and national burdens of major depression disorders and its attributable risk factors in adolescents and young adults aged 10–24 years from 1990 to 2021

Yutong Zhang, Zeheng Li, Feng Qian, Yu Xu et autres

BACKGROUND: Major depressive disorder (MDD) is an important public health problem among adolescents and young adults, and its increasing prevalence underscores the need for region-specific and age-specific interventions. Despite its increasing burden, comprehensive data on regional and longitudinal trends in MDD among …

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Editorial summary: Perinatal stress, inflammation, and maternal-child mental health

Ming Li, Xingshun Xu, Zhongliang Zhu, Weiwen Wang

This edition focuses on the intricate relationship between stress and inflammation during the perinatal period and their impact on the mental health of mothers and children. The scientific contributions of seven research papers and reviews are collated in this special issue, offering …

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Interleukin-18 interacts with NKCC1 to mediate brain injury after intracerebral hemorrhage

Beibei Xu, Hao Li, Zheng He, Zhongyu Gao et autres

Interleukin 18 (IL-18), a proinflammatory cytokine, has been implicated in various neurological disorders, including cerebrovascular disease and psychiatric disorders. In a previous study, IL-18 was observed to activate microglia and enhance the inflammatory response following intracranial hemorrhage (ICH). However, the underlying mechanism …

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Advances of the risk factors, immune and inflammation, therapy in postpartum post-traumatic stress disorder

Bo Yang, Zeheng Li, Xingshun Xu, Zhigang Miao

Postpartum Post-Traumatic Stress Disorder (PP-PTSD) is a psychological stress disorder that occurs as a result of traumatic childbirth experiences, posing significant risks to the physical and mental well-being of mothers. Although a variety of factors at different stages of the prenatal, traumatic …

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Assessing Stroke Recurrence Risk by Using a Lipoprotein-Associated Phospholipase A2 and Platelet Count-Based Nomogram

Yanlong Zhou, Yu Ying Feng, Jun Lu, Xingshun Xu

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Correction to “Celastrol Ameliorates Neuronal Mitochondrial Dysfunction Induced by Intracerebral Hemorrhage via Targeting cAMP‐Activated Exchange Protein‐1”

Xiang Li, Wenwen Liu, Guannan Jiang, Jinrong Lian et autres

Adv. Sci. 2024, e2307556. https://doi.org/10.1002/advs.202307556 Figure 5 Enrichment analysis to identify potential target signaling pathway for celastrol on neurons. A) Rbfox3 was used as a marker for neurons. B) 3D-Principal component analysis (PCA) was employed to identify the subclusters with the highest …