Relative change rate of anti-acetylcholine receptor antibodies concentration Correlates with the recurrence of myasthenia gravis in AChR-Abs-positive patients
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Le résumé fourni par la source
• A weak relationship between AChR-Abs concentration and MG severity at onset. • RCR of AChR-Abs concentration and MG subtypes was associated with MG recurrence. • Repeated AChR-Abs measurements are valuable for monitoring disease development. Myasthenia gravis (MG) is an autoimmune disease predominantly caused by anti-acetylcholine receptor antibodies (AChR-Abs). In this study, the relationship between MG relapse and AChR-Abs concentration were investigated. We retrospectively reviewed the clinical records of 41 patients with AChR-Abs-positive MG. Data collected included age, sex, MG status within 12 months (untreated status, UTMG; recurrence status, RCMG), MG subgroups, QMGs, AChR-Abs concentration and treatments. The relative change rate (RCR) of AChR-Abs concentration was calculated as: RCR(%)=(AChR-Abs–AChR-Abs UTMG )/AChR-Abs UTMG /month*100. ROC curve analysis and binary logistic regression analyses were used to evaluate the association between these factors and MG recurrence. Within 12 months, 12 patients experienced a recurrence (RCMG). A weak correlation was observed between AChR-Abs level in UTMG and QMGs (r = 0.336, p = 0.032). MG subgroups, QMGs, AChR-Ab levels and RCR differed significantly between RCMG and non-RCMG group. Single factor ROC curves indicated that AChR-Abs concentration, RCR and MG subgroups were related to MG recurrence (AUC = 0.724, 0.736, 0.736). Combining with RCR and MG subgroups, the ROC yielded an AUC of 0.899, demonstrating high sensitivity and specificity. RCR of AChR-Abs was correlated with MG progression, and repeated AChR-Abs measurements can assist in monitoring disease status and guiding therapeutic decision-making.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Relative change rate of anti-acetylcholine receptor antibodies concentration Correlates with the recurrence of myasthenia gravis in AChR-Abs-positive patients
- Date Crossref
- 01/06/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Soochow University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Soochow University pays non établi dans la noticeÉtablissement de santé
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Shanghai University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Traditional Chinese Medicine Hospital of Kunshan pays non établi dans la noticeÉtablissement de santé
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Kunshan Traditional Medicine Hospital pays non établi dans la noticeÉtablissement de santé
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School of Public Health Department of Epidemiology and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
Department of Neurology — Soochow University, First Affiliated Hospital of Soochow University et Shanghai University of Traditional Chinese Medicine, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.