Xiaona Chang

Concurrent icotinib and definitive radiotherapy followed by detection of an EGFR exon 20 insertion at disease progression in unresectable stage III EGFR S768I-mutant lung adenocarcinoma: a case report

Bingyue Wang, Yangchenxi Wang, Hongyuan Liu, Kaiyue Wang et autres

Uncommon EGFR mutations account for approximately 10-15% of all EGFR-mutated non-small cell lung cancer (NSCLC), and the optimal management of unresectable stage III disease harboring isolated EGFR S768I mutations remains poorly defined. We report the case of a 55-year-old woman with unresectable …

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Different Stages of Cardiovascular–Kidney–Metabolic Syndrome Associated With the Risk of All‐Cause and Cause‐Specific Mortality: Insights From Two Prospective Cohort Studies

Xiangyu Wang, Mengge Yang, Qiang Ma, Xiaona Chang et autres

Aims: Stage 3 in cardiovascular-kidney-metabolic (CKM) syndrome, defined as subclinical cardiovascular disease (CVD), diagnosis often relies on risk equivalents (very high-risk CKD or high 10-year CVD risk) due to the limited accessibility of diagnostic tools. A critical unanswered question is whether these …

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Radiotherapy for large ruptured hemorrhagic axillary lymph node metastasis from anaplastic lymphoma kinase-positive lung adenocarcinoma: A case report and review of literature

Zhimin Li, Yang-Chenxi Wang, Kai-Yue Wang, Ning-Jing Xie et autres

BACKGROUND: ) gene fusion is a molecular subtype of non-small cell lung cancer, representing 4%-6% of lung adenocarcinomas. Axillary lymph node (ALN) metastasis from lung cancer is rare, and massive bleeding from such lesions is an even more unusual and life-threatening complication. …

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Transformation and survival in patients with Waldenström macroglobulinemia: a population-based study

Yu Lei Du, Xiaona Chang, Xiangxiang Li, Shugang Xing

BACKGROUND: Waldenström's macroglobulinemia (WM) is a rare hematologic neoplasm characterized by an indolent clinical course. However, a significant proportion of patients undergo histological transformation to aggressive diffuse large B-cell lymphoma (DLBCL). Long-term population-based data on the transformation and survival are scarce. Based …

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Data-driven cluster analysis identifies distinct types of cardiovascular-kidney-metabolic syndrome

Mengge Yang, Chang Su, Xiaona Chang, Guang Wang et autres

INTRODUCTION: The current staging criteria for cardiovascular-kidney-metabolic (CKM) syndrome demonstrate extensive clinical heterogeneity, imposing constraints on risk prognostication and precision medicine. OBJECTIVES: This study aimed to refine the subtyping of CKM syndrome using clinical biomarkers to enhance risk assessment and personalized prevention. …

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PathVG: A New Benchmark and Dataset for Pathology Visual Grounding

Chunlin Zhong, Shuang Hao, Junhua Wu, Xiaona Chang et autres

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Novel Insights into the Causal Relationship between Antidiabetic Drugs and Adverse Perinatal Outcomes: A Mendelian Randomization Study

Chang Su, Xueqing He, Xiaona Chang, Juan Tian et autres

BACKGRUOUND: Hyperglycemia during pregnancy increases the risk of adverse perinatal outcomes and birth defects. Evidence regarding the long-term safety of antidiabetic drugs during pregnancy is still lacking. METHODS: A two-sample Mendelian randomization (MR) study was performed to assess the causal association between …

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Effects of Different Neuraxial Analgesia Modalities on the Need for Physician Interventions in Labour: A Network Meta-analysis

Mo Wang, Jialyu Huang, Xiaona Chang

(Eur J Anaesthesiol. 2024;41(6):411–420. doi: 10.1097/EJA.0000000000001986 Methods for initiating labor analgesia include epidural (EPI), combined spinal epidural (CSE), and dural puncture epidural (DPE). Methods for maintaining labor analgesia include patient-controlled epidural analgesia (PCEA), continuous epidural infusion (CLE), and programmed intermittent epidural bolus …

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Association between saturated and polyunsaturated fatty acid proportions in total fat intake and mortality risk: mediation by the neutrophil percentage-to-albumin ratio

Yanyan Liu, Jiaxuan Wang, Xiaona Chang, Xiaoying Ren et autres

BACKGROUND: For over half a century, dietary guidelines have consistently advocated for the substitution of saturated fatty acids (SFA) with monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) as a cornerstone strategy for health life, but evidence on independent associations between specific fatty …

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Association between saturated and polyunsaturated fatty acid proportions in total fat intake and mortality risk: mediation by the neutrophil percentage-to-albumin ratio

Yanyan Liu, Jiaxuan Wang, Xiaona Chang, Xiaoying Ren et autres

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Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases

Qiuyue Wen, Qiuhui Li, Wei Qiang Yang, Xiaona Chang et autres

macrophages were abundant in FL, DLBCL and ENKTL. The present report could broaden our understanding of composite lymphoma.

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Evaluating CSPG4 expression in esophageal basaloid squamous cell carcinoma and conventional squamous cell carcinoma: a multi-institutional retrospective study in China

Dongxian Jiang, Xu Chen, Yan Jun Li, Ling Nie et autres

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