Peter Herrmann

Recirculation Quantified by Trans–Extracorporeal Membrane Oxygenation Thermodilution to Predict Mixed Venous Oxygenation during Veno-venous Extracorporeal Membrane Oxygenation: An In Vivo Porcine Study

Mattia Busana, Stefano Lazzari, Jona Wassong, Simone Gattarello et autres

BACKGROUND: Recirculation is a major contributor to refractory hypoxemia during veno-venous extracorporeal membrane oxygenation (V-V ECMO), yet it remains difficult to measure at the bedside. In an animal study, the authors applied the trans-extracorporeal membrane oxygenation thermodilution (TET) to quantify the phenomenon, …

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Impact of positive end-expiratory pressure and recruitment maneuver on healthy lungs in dogs assessed by functional and anatomical monitoring methods

Martina Mosing, Andreas D. Waldmann, Thomas C. Gent, Giselle L. Hosgood et autres

Introduction Atelectasis is a common occurrence during anesthesia, and positive end-expiratory pressure (PEEP) ventilation and recruitment maneuvers (RM) can be used to mitigate this. However, both techniques may be associated with side effects in healthy lungs, and close monitoring is indicated. This …

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Predictors of VILI risk: driving pressure, 4DPRR and mechanical power ratio—an experimental study

Mauro Galizia, Valentina Ghidoni, Giulia Catozzi, Stefano Giovanazzi et autres

Abstract Background Ventilator-induced lung injury (VILI) is one of the side effects of mechanical ventilation during ARDS; a prerequisite for averting it is the quantification of its risk factors associated with a given ventilatory setting. Many clinical variables have been proposed as …

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Rethinking ARDS classification: oxygenation impairment fails to predict VILI risk

Giulia Catozzi, Tommaso Pozzi, Domenico Nocera, Beatrice Donati et autres

The selection and intensity of respiratory support for ARDS are guided by PaO 2 /FiO 2 . However, ventilator-induced lung injury (VILI) is linked to respiratory mechanics and ventilator settings. We explored whether the VILI risk is related to ARDS severity based …

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Impact of Fluid Balance on the Development of Lung Injury

Simone Gattarello, Tommaso Pozzi, Mauro Galizia, Mattia Busana et autres

Abstract Rationale The pathophysiological relationship among fluid administration, fluid balance, and mechanical ventilation in the development of lung injury is unclear. Objectives To quantify the relative contributions of mechanical power and fluid balance in the development of lung injury. Methods Thirty-nine healthy …

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Correction: Mechanical power ratio threshold for ventilator-induced lung injury

Rosanna D’Albo, Tommaso Pozzi, Rosmery Valentina Nicolardi, Mauro Galizia et autres

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Mechanical power ratio threshold for ventilator-induced lung injury

Rosanna D’Albo, Tommaso Pozzi, Rosmery Valentina Nicolardi, Mauro Galizia et autres

Abstract Rationale Mechanical power (MP) is a summary variable incorporating all causes of ventilator-induced-lung-injury (VILI). We expressed MP as the ratio between observed and normal expected values (MPratio). Objective To define a threshold value of MPratio leading to the development of VILI. …

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Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data

Simone Gattarello, Fábio Lombardo, Federica Romitti, Rosanna D’Albo et autres

BACKGROUND: The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney failure and the hemodynamic changes consequent to experimental high-power mechanical …

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High- versus Low-Flow Extracorporeal Respiratory Support in Experimental Hypoxemic Acute Lung Injury

Serena Brusatori, Carmelo Zinnato, Mattia Busana, Federica Romitti et autres

Abstract Rationale In the EOLIA (ECMO to Rescue Lung Injury in Severe ARDS) trial, oxygenation was similar between intervention and conventional groups, whereas V˙ e was reduced in the intervention group. Comparable reductions in ventilation intensity are theoretically possible with low-flow extracorporeal …

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Limitations: Decision Making Under the Condition of Uncertainty and with Limited Knowledge

Peter Herrmann

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Pandemics as Matter of a System Crisis

Peter Herrmann

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Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome

Roberta Maj, Paola Palermo, Simone Gattarello, Serena Brusatori et autres

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