Brendan Foley

Assessment Of Maxillary Bone Density And Thickness In Cleft Versus Non-cleft Patients Undergoing Le Fort I Osteotomy

Edgar Soto, Thomas Ren, Brendan Foley, Pasha Shakoori et autres

PURPOSE: Le Fort I advancement relies on controlled osteotomies through the nasomaxillary buttress and pterygomaxillary junction, two key regions for down-fracture and mobilization. In patients with cleft palate (CP), increased bone density, altered maxillary dimensions, and regional scarring may influence bone quality, …

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Manipulating thymic epithelial cells to modulate thymic selection and reactivity of T cells 4106

Lotte van den Goor, Brendan Foley, Valentina Consoli, Fabio Russo et autres

Abstract Description T cells are activated in response to foreign antigens, enabling them to successfully defend the organism. However, this reactivity becomes problematic in auto-immune diseases, where T cells recognize self-antigens as foreign, and in transplantation, where T cells trigger rejection by …

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Engineering the composition of thymic stroma to improve transplant tolerance induction 4495

Brendan Foley, Lotte van den Goor, Valentina Consoli, Fabio Russo et autres

Abstract Description Transplant recipients are put on life-long immunosuppression, experiencing side effects and incomplete control of rejection. Among alternative immunotherapies, bone marrow transplantation has shown the most promise, but remains limited in its clinical application. Its therapeutic efficacy relies prominently on altering …

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Remote diffuse multi-coronary artery spasm following pulmonary vein and posterior wall isolation, using a focal monopolar pulsed field ablation catheter

James Mannion, Colin Gorry, Brendan Foley, Stephen Tuohy

Ablation with pulsed field (PF) energy generates irreversible electroporation in cardiac myocytes, inducing apoptosis and death, with resultant scar and electrophysiological block. The uptake of PF energy in catheter ablation continues to rapidly grow world-wide. Though PF was initially suspected to have …

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SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly

Shuying He, Pin Lyu, Marnie W. Skinner, Anthony Desotell et autres

Histone mRNAs are the only nonpolyadenylated mRNAs in eukaryotic cells and require specialized processing in the histone locus body (HLB), a nuclear body where essential processing factors, including the U7 snRNP, are concentrated. Recent studies have revealed that misregulation of histone pre-mRNA …

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SUMO2 Promotes Histone Pre-mRNA Processing by Stabilizing Histone Locus Body Interactions and Facilitating U7 snRNP Assembly

Shuying He, Pin Lyu, Marnie W. Skinner, Anthony Desotell et autres

ABSTRACT Histone mRNAs are the only non-polyadenylated mRNAs in eukaryotic cells and require specialized processing in the histone locus body (HLB), a nuclear body where essential processing factors, including the U7 snRNP, are concentrated. Recent studies have revealed that misregulation of histone …

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T cell responsiveness to IL-10 defines the immunomodulatory effect of costimulation blockade via anti-CD154 and impacts transplant survival

Marcos Iglesias, Darrel Bibicheff, Alexander Komin, Maria Chicco et autres

Abstract Costimulation blockade (CoB)-based immunotherapy is a promising alternative to immunosuppression for transplant recipients; however, the current limited understanding of the factors that impact its efficacy restrains its clinical applicability. In this context, pro- and anti-inflammatory cytokines are being recognized as having …

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Solid organ and vascularized composite allotransplantation have distinct requirements for localized delivery of enhanced costimulation blockade to control rejection

Giorgio Raimondi, Amy Bodine, Monessha Nambiar, Xiomara Calderón‐Colón et autres

Abstract We recently demonstrated, in a mouse heart transplant model, the therapeutic effect of Enhanced Costimulation Blockade: the transient combination of CTLA4-Ig with the JAK inhibitor Tofacitinib (Tofa). In the same model, we also proved the efficacy of a graft-localized delivery by …

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Catabolism of the Lipofuscin Cycloretinal by MsP1

Irum Perveen, Brett A. Johnson, Vishruth Gowda, Brendan Foley et autres

Age-related macular degeneration (AMD) is a debilitating eye disease that tends to affect people over the age of 55. Lipofuscins are autofluorescent, toxic byproducts of the visual cycle thought to contribute toward the progression of the disease. Targeting the accumulation of lipofuscin …

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OP06.09: Does fetal growth predict low birthweight in suspected late fetal growth restriction?

Tamara Stampalija, Hans Wolf, Brendan Foley, Katie Stephens et autres

To evaluate the prediction of low birth weight (BW) using longitudinal individual fetal growth measurement in suspected late fetal growth restriction (FGR). This is a secondary analysis from the multicentre observational study (TRUFFLE2) from April 2017 to July 2018.Women at 32–36 weeks …

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OC04.02: Fetal growth rate and cerebral blood flow redistribution in suspected late fetal growth restriction

Tamara Stampalija, Hans Wolf, Brendan Foley, Katie Stephens et autres

To assess the association of fetal growth and fetal cerebral blood flow redistribution, umbilico-cerebral ratio (UCR) or short-term neonatal outcome in suspected late fetal growth restriction (FGR). This is a secondary analysis from multicentre observational study (TRUFFLE2) from April 2017 to July …

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Investigations of Azinomycin Biosynthesis and Macular Degenerative Diseases

Brendan Foley

The production and discovery of natural products has been a beneficial tool that provides a window into the bioorganic chemistry of organisms and offers a template for drug discovery and development. Natural products can be utilized to positively impact the deleterious effects …