Julia Kölle

Benefits of Usability Evaluation in the Development Process of Diabetes Technologies Using the Example of a Continuous Glucose Monitoring System Prototype

Anne Beltzer, Julia Kölle, Marta Gil Miró, Stefan Pleus et autres

BACKGROUND: Usability engineering analyzes the interaction between the intended users and a device. Its implementation is mandatory for manufacturers to obtain regulatory approval for the European market. The aim of this evaluation was assessing the role of usability testing in the development …

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Performance Assessment of Three Continuous Glucose Monitoring Systems in Adults With Type 1 Diabetes

Julia Kölle, Manuel Eichenlaub, Jochen Mende, Manuela Link et autres

BACKGROUND: FIND, the global alliance for diagnostics, identified the nonmarket-approved continuous glucose monitoring (CGM) system, FiberSense system (FBS), as a potential device for use in low- and middle-income countries. Together with two market-approved, factory-calibrated CGM systems, namely, the FreeStyle Libre 2 (FL2) …

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User Performance Evaluation and System Accuracy Assessment of Four Blood Glucose Monitoring Systems With Color Coding of Measurement Results

Stefan Pleus, Annette Baumstark, Sebastian Schauer, Julia Kölle et autres

BACKGROUND: Blood glucose monitoring systems (BGMSs) are a cornerstone in diabetes management. They have to provide sufficiently accurate results in the hands of lay users, particularly in insulin-treated patients. The aim of this study was user performance evaluation and system accuracy assessment …

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Targeted deletion of Interleukin-3 results in asthma exacerbations

Julia Kölle, Theodor Zimmermann, Alexander Kiefer, Ralf J. Rieker et autres

The cytokine interleukin-3 (IL-3) acts on early hematopoietic precursor cells. In humans, T reg cells secrete IL-3 and repress inflammatory cells except for basophils. The present study aims to elucidate the contribution of IL-3 in the development and the course of allergic …

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Hildegard von Bingen. Liber simplicis medicinae

Julia Kölle

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Darja Andreev, Mengdan Liu, Katerina Kachler, Mireia Llerins Perez et autres

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Respiratory infections regulated blood cells IFN‐β‐PD‐L1 pathway in pediatric asthma

Julia Kölle, Patricia Haag, Tytti Vuorinen, Alexander Kiefer et autres

BACKGROUND: Respiratory infections, in general, and rhinovirus infection specifically are the main reason for asthma exacerbation in children and programmed cell death protein 1 ligand (PD-L1) expression inhibits T cell responses. OBJECTIVE: Could the interferon (IFN) type I expression in peripheral blood …

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Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2)

Sonja Koch, Lisa Knipfer, Julia Kölle, Hooman Mirzakhani et autres

Abstract Here we investigated the role of NFAT-interacting protein (NIP)-45, an Interleukin (IL)-4 inducing Transcription Factor, and its impact on the differentiation of Group 2 Innate -Lymphoid -Cells (ILC2s) in the pathogenesis of asthma. NIP45, a transcription factor regulating NFATc1 activity, mRNA …

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Immunoregulatory role of acid sphingomyelinase in allergic asthma

Nina Sopel, Julia Kölle, Sonja Dumendiak, Sonja Koch et autres

Summary Acid sphingomyelinase (ASM) is one of the enzymes that catalyzes the breakdown of sphingomyelin to ceramide and phosphorylcholine. In this study, we aimed at elucidating the role of ASM in allergic asthma. We used an ovalbumin‐induced murine model of asthma where …

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Versteinertes Blut. Heilig-Blut-Säulen in der flämischen Malerei um 1500

Julia Kölle

The Unresolved Role of Interferon-λ in Asthma Bronchiale

Nina Sopel, Andreas Pflaum, Julia Kölle, Susetta Finotto

is a disease of the airways with increasing incidence, that often begins during infancy. So far, therapeutic options are mainly symptomatic and thus there is an increasing need for better treatment and/or prevention strategies. Human rhinoviruses (HRVs) are a major cause of …

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Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

Friedrich Hahn, Adrian Schmalen, Christian Setz, Melanie Friedrich et autres

There is a significantly higher risk for type II diabetes in HIV-1 carriers, albeit the molecular mechanism for this HIV-related pathology remains enigmatic. The 52 amino acid HIV-1 p6 Gag protein is synthesized as the C-terminal part of the Gag polyprotein Pr55. …

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