Martha L. Bustos

Abstract 13829: Low Density Lipoprotein Receptor on the Immune Cells Influence the Atherosclerosis Progression in C57bl/6 Mice

Jitendra Singh Kanshana, Martha L. Bustos, APOORVA NARAIN, Kruthika Doreswamy et autres

Introduction: Atherosclerosis is the leading cause of cardiovascular diseases (CVDs). Over the past three decades, the clinical focus has been reducing plasma lipids and other traditional risk factors to reduce cardiovascular mortality. More recently, the CANTOS trial showed that inflammation is a …

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The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth

Martha L. Bustos, Steve N. Caritis, Kathleen A. Jablonski, Uma M. Reddy et autres

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30: The impact of cytochrome p450 3a and progesterone receptor polymorphisms on 17-ohpc concentrations and efficacy

Martha L. Bustos

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Polymorphisms in CYP 1A1 and CYP 3A5 Genes Contribute to the Variability in Granisetron Clearance and Exposure in Pregnant Women with Nausea and Vomiting

Martha L. Bustos, Yang Zhao, Huijun Chen, Steve N. Caritis et autres

BACKGROUND: Nausea and vomiting affect up to 90% of pregnant women. Granisetron is a potent and highly selective serotonin receptor antagonist and is an effective antiemetic. Findings from a prior study in pregnant women demonstrated a large interindividual variability in granisetron exposure. …

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Nausea and vomiting of pregnancy - What's new?

Martha L. Bustos, Raman Venkataramanan, Steve N. Caritis

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Depletion of Bone Marrow CCSP-Expressing Cells Delays Airway Regeneration

Martha L. Bustos, Marco Mura, David M. Hwang, Olga Ludkovski et autres

The contribution of bone marrow cells (BMC) in lung repair is controversial. We previously reported a subpopulation of BMC that express Clara cell secretory protein (CCSP). To determine the contribution of endogenous CCSP(+) BMC to airway regeneration, we performed bone marrow transplantation …

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Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response

Martha L. Bustos, Luai Huleihel, Maria G. Kapetanaki, Christian L. Lino Cardenas et autres

RATIONALE: Aging is characterized by functional impairment and reduced capacity to respond appropriately to environmental stimuli and injury. With age, there is an increase in the incidence and severity of chronic and acute lung diseases. However, the relationship between age and the …

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Activation of Human Mesenchymal Stem Cells Impacts Their Therapeutic Abilities in Lung Injury by Increasing Interleukin (IL)-10 and IL-1RN Levels

Martha L. Bustos, Luai Huleihel, Ernest Michael Meyer, Albert D. Donnenberg et autres

Acute respiratory distress syndrome (ARDS) is an important cause of morbidity and mortality, with no currently effective therapies. Several preclinical studies have shown that human mesenchymal stem cells (hMSCs) have therapeutic potential for patients with ARDS because of their immunomodulatory properties. The …

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Bone Marrow Cells Expressing Clara Cell Secretory Protein Increase Epithelial Repair After Ablation of Pulmonary Clara Cells

Martha L. Bustos, Marco Mura, Paula Marcus, David M. Hwang et autres

We have previously reported a subpopulation of bone marrow cells (BMC) that express Clara cell secretory protein (CCSP), generally felt to be specific to lung Clara cells. Ablation of lung Clara cells has been reported using a transgenic mouse that expresses thymidine …

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LSC 2012 abstract - Age-related changes in the relative expression of functional genes in mesenchymal stem cells

Martha L. Bustos, Maria G. Kapetanaki, Ernest Michael Meyer, Albert D. Donnenberg et autres

Age-associated changes increased susceptibility to a variety of lung pathologies. Recently, mesenchymal stem cells or B-MSCs have emerged as a critical reparative response mechanism to lung injury. We had demonstrated an association, in animal models, between age and an increase in the …

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Age-Related Changes In The Relative Expression Of Functional Genes In Mesenchymal Stem Cells

Martha L. Bustos, Maria G. Kapetanaki, Machael Meyer, Albert D. Donnenberg et autres

Defective DNA Repair On The Ercc1-/Mice Causes Accelerated Aging And Increased Susceptibility To Lung Injury And Fibrosis

Martha L. Bustos, Marta Bueno, Alice K. Robison, Joseph Sciurba et autres