Jessica D. Daley

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

M Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey et autres

Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous …

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Data from Advancing Preclinical Biology for Ewing Sarcoma: An International Effort

Filemon S. Dela Cruz, Elizabeth A. Stewart, Didier Surdez, Jessica D. Daley et autres

Abstract Ewing sarcoma is an aggressive bone and soft-tissue cancer affecting adolescents and young adults. In vitro and in vivo models of Ewing sarcoma have been instrumental in advancing our understanding of Ewing sarcoma biology and essential in evaluating potential therapies, particularly …

Supplemental Table 1 from Advancing Preclinical Biology for Ewing Sarcoma: An International Effort

Filemon S. Dela Cruz, Elizabeth A. Stewart, Didier Surdez, Jessica D. Daley et autres

EWS cell line STR profiles

Abstract A016: ews-nf: A custom workflow for tumor cell annotation and analysis of single-cell RNA-sequencing of paired patient Ewing sarcoma specimens from the Sean Karl cohort

Allegra G. Hawkins, Stephanie J. Spielman, Joshua A. Shapiro, Abbe Pannucci et autres

Abstract Ewing sarcoma (EwS) is a fusion oncoprotein-driven primary bone cancer that demonstrates vast intra- and inter-tumoral heterogeneity. Tumor cell subpopulations, tumor progression, and therapeutic vulnerabilities of cell subpopulations are poorly understood. Paired patient samples (primary and metastatic disease or relapse) are …

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Future Directions and Priorities for Cellular Therapy in Sarcoma: A Report from the Strategic Advances in Sarcoma Science Cell Therapy Breakout

Jacqueline Oliva, David Milewski, Lauren B. Banks, Kelly M. Bailey et autres

BACKGROUND: In September of 2024, the 2nd annual meeting of the Strategic Advances in Sarcoma Science (SASS) convened at the National Institutes of Health. This gathering of national sarcoma experts focused on preclinical studies, clinical trials, opportunities, challenges, and future directions in …

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Advancing Preclinical Biology for Ewing Sarcoma: An International Effort

Filemon S. Dela Cruz, Elizabeth Stewart, Didier Surdez, Jessica D. Daley et autres

Ewing sarcoma is an aggressive bone and soft-tissue cancer affecting adolescents and young adults. In vitro and in vivo models of Ewing sarcoma have been instrumental in advancing our understanding of Ewing sarcoma biology and essential in evaluating potential therapies, particularly for …

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Supplementary Figure S8 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

Jessica D. Daley, Elina Mukherjee, David Ferraro, Shanthi Bhaskar et autres

Supplementary Figure S8. Differentially expressed genes in Ewing sarcoma tumor cells associated with each cellular neighborhood.

Supplementary Figure S9 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

Jessica D. Daley, Elina Mukherjee, David Ferraro, Shanthi Bhaskar et autres

Supplementary Figure S9. HLA class I expression is modifiable and upregulated in Ewing sarcoma cells following interferon-gamma (IFNγ) treatment.

Supplementary Table S1 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

Jessica D. Daley, Elina Mukherjee, David Ferraro, Shanthi Bhaskar et autres

Supplementary Table S1. Proteins included in the Nanostring GeoMx immuno-oncology panel.

Supplementary Figure S6 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

Jessica D. Daley, Elina Mukherjee, David Ferraro, Shanthi Bhaskar et autres

Supplementary Figure S6. Identification of groups of patients based on the frequency of spatially resolved cellular neighborhoods.

Supplementary Figure S2 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

Jessica D. Daley, Elina Mukherjee, David Ferraro, Shanthi Bhaskar et autres

Supplementary Figure S2. Quantification of immune cell subsets utilizing multiplex immunohistochemistry.

Supplementary Figure S7 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

Jessica D. Daley, Elina Mukherjee, David Ferraro, Shanthi Bhaskar et autres

Supplementary Figure S7. Spatial distribution of cells from each patient tumor biopsy and enumeration of the proportion of cells with in each spatially resolved cell neighborhoods in each biopsy.