Chanon Kunasol

Probiotic Lactobacillus reuteri KUB-AC5 provides cardioprotection via mitigating cardiac mitochondrial dysfunction in obese rats

Chanisa Thonusin, Titikorn Chunchai, Parameth Thiennimitr, Chayodom Maneechote et autres

Cardiac mitochondrial dysfunction is a crucial mechanism underlying obesity-induced cardiovascular diseases. A close link between obesity and gut microbiota has been revealed, and the benefits of gut microbiota modulation by probiotics have been widely identified. Although the probiotic Lactobacillus reuteri KUB-AC5 exerted …

Characterization of gut microbiota in wild Asian elephants (Elephas maximus) from five forests across Thailand

Supika Kantirakoon, Sarisa Klinhom, Chanon Kunasol, Chaiya Huayhongthong et autres

The gut microbiota plays a critical role in mammalian health, yet remains poorly understood in wild Asian elephants (Elephas maximus). This study characterized the gut microbiome of wild elephants using 16S rRNA sequencing of fecal samples collected from five natural habitats in …

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Prognostic Role of Gut Microbiota and Clinical Parameters in Predicting Survival in Advanced Cholangiocarcinoma Patients Receiving Chemotherapy

Thanika Ketpueak, Chanon Kunasol, Kanokphong Suparan, Nakarin Inmutto et autres

Introduction: Cholangiocarcinoma (CCA) is high prevalent in Asia.Emerging evidence indicates gut and tissue microbiota are involved in CCA carcinogenesis and progression.This study investigated the potential role of gut and tissue microbiota as prognostic biomarkers associated with treatment outcomes in advanced intrahepatic CCA …

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Stage‐Associated Subgingival Dysbiosis Across the Periodontal Disease Spectrum in a Thai Cohort

Teerat Sawangpanyangkura, Kanokphong Suparan, Chanyanuch Wechwithayakhlung, Chanon Kunasol et autres

AIMS: This cross-sectional study aimed to investigate the subgingival microbiota and predict functional profiles across the 2018 EFP/AAP periodontal disease spectrum in a Thai clinical cohort. MATERIALS AND METHODS: Subgingival plaque from 100 participants (gingivitis, n = 30; Stage II-IV periodontitis, n …

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Inhibiting Purinergic Receptor ( P2X7R ) Alleviates Depression‐ and Anxiety‐Like Behaviors in Obese Rats With Immune Challenge

Titikorn Chunchai, Hiranya Pintana, Patcharapong Pantiya, Chanon Kunasol et autres

AIM: Chronic high-fat diet (HFD) consumption combined with lipopolysaccharide (LPS) challenge promotes microglial hyperactivation, brain inflammation, reduced neurogenesis, and depression-like behavior. LPS also increases adenosine triphosphate (ATP) release from immune and dying cells, activating microglia through the purinergic P2X7R receptor. However, the …

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Development of gut microbiota composition in captive Asian elephants: a year-long analysis

Sarisa Klinhom, Chanon Kunasol, Sirawit Sriwichaiin, Sasiwan Kerdphoo et autres

The establishment of gut microbiota is vital for the health and development of elephant calves, especially during their first year of life. This study investigates the transformation of the gut microbiome in captive Asian elephant calves, focusing the influence of maternal milk …

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Longitudinal analysis of gut microbiota dysbiosis and bacterial signatures predictive of postoperative enterocolitis in children with Hirschsprung disease

Sireekarn Chantakhow, Chanon Kunasol, Jiraporn Khorana, Kanokkan Tepmalai et autres

BACKGROUND: We aimed to investigate differences in gut microbiota between patients with Hirschsprung disease (HSCR) and healthy children; assess longitudinal changes in the microbiota of patients with HSCR from diagnosis through postoperative period; and identify microbial markers predictive of postoperative HSCR-associated enterocolitis …

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Association Between Hemodynamic Parameters and Gut Microbiota in Fontan Circulation: A Cross‐Sectional Study

Saviga Sethasathien, Chanon Kunasol, Suchaya Silvilairat, Rekwan Sittiwangkul et autres

BACKGROUND: The Fontan operation results in chronic hemodynamic alterations, including central venous hypertension, which may contribute to gut dysbiosis. This study aimed to compare gut microbiota profiles between Fontan patients and age- and sex-matched healthy controls and to examine how catheter-measured hemodynamic …

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Probiotics Lactobacillus reuteri KUB‐AC5 exerts neuroprotective effects on brain pathologies and attenuates depressive‐like behavior in obese insulin‐resistant rats

Titikorn Chunchai, Hiranya Pintana, Patcharapong Pantiya, Busarin Arunsak et autres

BACKGROUND: Chronic consumption of a high-fat diet (HFD) alters gut microbiota, induces endotoxemia, and impairs cognitive function (1, 2). Previous studies have shown that the administration of probiotics, such as Lactobacillus paracasei HII01, attenuated gut dysbiosis, alleviated metabolic disturbance, improved brain mitochondrial …

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The administration of purinergic receptor P2X7 inhibitor alleveates depressive‐like behavior in obese and lean rats with immune challenge

Titikorn Chunchai, Hiranya Pintana, Patcharapong Pantiya, Busarin Arunsak et autres

BACKGROUND: Chronic high-fat diet (HFD) consumption and lipopolysaccharide (LPS) injection prime microglia, enhance inflammatory responses, decrease neurogenesis, resulting in depressive-like behavior. It has been reported that LPS stimulates adenosine triphosphate production from immune cells and dead cells, activating microglia via the purinergic …

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Acute coronary syndrome patients exhibit cognitive impairments and gut dysbiosis compared to high cardiovascular risk patients

Narueporn Pagowong, Kanokphong Suparan, Chanon Kunasol, Chotrawee Piriyakunthorn et autres

BACKGROUND: Previous studies have shown that gut dysbiosis correlates with cognitive impairments in both animal models and clinical settings. Additionally, alterations in gut microbiota have been linked to acute coronary syndrome (ACS). However, the relationship between gut microbiota changes and cognitive outcomes …

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Dapagliflozin enhances gut barrier function in rats with chronic myocardial infarction by modulating gut microbiota balance

Chanon Kunasol, Chayodom Maneechote, Nattayaporn Apaijai, Chanisa Thonusin et autres

Background: Chronic myocardial infarction (CMI) is a leading cause of heart failure and is increasingly recognized as a systemic condition involving multi-organ dysfunction, particularly impaired gut health due to systemic inflammation and metabolic disturbances. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, exerts cardioprotective …

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