Shelley B. Hooks

Bioinformatic analysis identifies RGS10 as a modulator of BV-2 microglia migration

Shwetal Talele, Menbere Wendimu, Shelley B. Hooks, Benita Sjögren

Regulator of G protein signaling 10 (RGS10) is a GTPase activating protein, selective for Gα i , that has been proposed to play a role in suppressing microglia-driven neuroinflammation. RGS10 expression in microglia is suppressed by inflammatory stimuli and aging, and loss …

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Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2025.3

Katelin E. Ahlers‐Dannen, Harrison J. McNabb, Carolina Montañez‐Miranda, Osita W. Ogujiofor et autres

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins …

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Impact of RGS10 on Microglial Cell Migration and Proliferation

Shwetal Talele, Shelley B. Hooks, Benita Sjögren

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The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets

S P H Alexander, Eamonn Kelly, Alistair Mathie, John A. Peters et autres

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. …

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Transcriptional Analysis of RGS10 Function in Microglia

Shwetal Talele, Stephanie González, Violeta Saldarriaga, Shelley B. Hooks et autres

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Impact of Microglial RGS10 Regulation of Inflammatory Mediators in the Glioblastoma Tumor Microenvironment

Phillip T. Dean, Shelley B. Hooks

Pleiotropic effects of the COX-2/PGE2 axis in the glioblastoma tumor microenvironment

Phillip T. Dean, Shelley B. Hooks

Glioblastoma (GBM) is the most common and aggressive form of malignant glioma. The GBM tumor microenvironment (TME) is a complex ecosystem of heterogeneous cells and signaling factors. Glioma associated macrophages and microglia (GAMs) constitute a significant portion of the TME, suggesting that …

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Microglia Phenotypes in Aging and Neurodegenerative Diseases

Menbere Wendimu, Shelley B. Hooks

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the central drivers of neuroinflammation. Numerous …

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Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord

Dylan W. Maixner, David Christy, Lingwei Kong, Viacheslav Viatchenko‐Karpinski et autres

Spinal neuroinflammation plays a critical role in the genesis of neuropathic pain. Accumulating data suggest that abscisic acid (ABA), a phytohormone, regulates inflammatory processes in mammals. In this study, we found that reduction of the LANCL2 receptor protein but not the agonist …

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

S P H Alexander, Eamonn Kelly, Alistair Mathie, John A. Peters et autres

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where …

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Dominant-negative Inhibition of Pheromone Receptor Signaling by a Single Point Mutation in the G Protein α Subunit

Shelley B. Hooks, Yuh-Lin Wu, Henrik Dohlman, T. Kendall Harden

In yeast, two different constitutive mutants of the G protein alpha subunit have been reported. Gpa1(Q323L) cannot hydrolyze GTP and permanently activates the pheromone response pathway. Gpa1(N388D) was also proposed to lack GTPase activity, yet it has an inhibitory effect on pheromone …

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RGS6, RGS7, RGS9, and RGS11 Stimulate GTPase Activity of G i Family G-proteins with Differential Selectivity and Maximal Activity

Andrejs M. Krumins, Erik T. Bodor, Gary L. Waldo, James Corbitt et autres

Regulator of G-protein signaling (RGS) proteins are GTPase activating proteins (GAPs) of heterotrimeric G-proteins that alter the amplitude and kinetics of receptor-promoted signaling. In this study we defined the G-protein alpha-subunit selectivity of purified Sf9 cell-derived R7 proteins, a subfamily of RGS …

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