Menbere Wendimu

Bioinformatic analysis identifies RGS10 as a modulator of BV-2 microglia migration

Shwetal Talele, Menbere Wendimu, Shelley B. Hooks, Benita Sjögren

Regulator of G protein signaling 10 (RGS10) is a GTPase activating protein, selective for Gα i , that has been proposed to play a role in suppressing microglia-driven neuroinflammation. RGS10 expression in microglia is suppressed by inflammatory stimuli and aging, and loss …

us (code pays fourni par la source)

Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2025.3

Katelin E. Ahlers‐Dannen, Harrison J. McNabb, Carolina Montañez‐Miranda, Osita W. Ogujiofor et autres

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins …

us, ir (code pays fourni par la source)

The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets

S P H Alexander, Eamonn Kelly, Alistair Mathie, John A. Peters et autres

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. …

gb, us, ch, at, sg, ir, au (code pays fourni par la source)

Microglia Phenotypes in Aging and Neurodegenerative Diseases

Menbere Wendimu, Shelley B. Hooks

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the central drivers of neuroinflammation. Numerous …

us (code pays fourni par la source)

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

S P H Alexander, Eamonn Kelly, Alistair Mathie, John A. Peters et autres

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where …

gb, us, au, ch, at, sg, ir (code pays fourni par la source)

Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2

Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Christopher Bodle, Josephine Bou Dagher et autres

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins …

us, ir (code pays fourni par la source)

RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia

Menbere Wendimu, Mohammed Alqinyah, Stephen A. Vella, Phillip T. Dean et autres

us (code pays fourni par la source)

Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Christopher Bodle, Josephine Bou Dagher et autres

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins …

us (code pays fourni par la source)

Regulator of G protein Signaling 10 (RGS10) functionally interacts with store‐operated calcium entry machinery to regulate COX‐2 and TNF‐α in Microglia

Menbere Wendimu, Mohammed Alqinyah, Stephen A. Vella, Silvia N.J. Moreno et autres

Activation of microglia is a driving factor of neuroinflammation and a hallmark of neurodegenerative diseases. The central inflammatory enzyme cyclooxygenase 2 (COX‐2) and the pro‐inflammatory cytokine tumor necrosis factor‐alpha (TNF‐α) mediate critical features of microglial activation responses, and their upregulation in the …

The role of calcium in RGS10 regulation of inflammatory signaling in microglia

Faris Almutairi, Mohammed Alqinyah, Menbere Wendimu, Stephen A. Vella et autres

Regulator of G‐protein Signaling (RGS10) is a member of a family of proteins that canonically bind and terminate signaling downstream of G proteins. RGS10 is highly expressed in brain and immune cells, with specific enrichment in microglia. Microglial RGS10 serves an anti‐inflammatory …

us (code pays fourni par la source)

A Novel Interaction between Regulator of G‐protein Signaling (RGS10) and STIM2 Identifies New Mechanism for the Regulation of COX‐2 in Microglia

Menbere Wendimu, Mohammed Alqinyah, Paul J. Freeman, Stephen A. Vella et autres

Regulator of G‐protein Signaling 10 (RGS10) mediates strong anti‐inflammatory and neuroprotective effects. RGS10 is highly enriched in microglia where it suppresses the expression of many proinflammatory genes, including the key inflammatory enzyme cyclooxygenase 2 (COX‐2). The neuroprotective and anti‐inflammatory effects of RGS10 …

us (code pays fourni par la source)

RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein–Independent Mechanism

Mohammed Alqinyah, Faris Almutairi, Menbere Wendimu, Shelley B. Hooks

us (code pays fourni par la source)