Gustavo A. Orozco

Synchrotron phase-contrast microtomography reveals the impact of degeneration on the 3D structure of human articular cartilage

Edvin Tobias Bokvist Wrammerfors, Maria Pierantoni, Hector Dejea, Amanda Sjögren et autres

OBJECTIVE: To evaluate quantitative and qualitative cell and tissue properties of human articular cartilage using phase-contrast synchrotron microtomography to determine what biological information can be obtained in comparison to traditional histopathology. DESIGN: Human knee cartilage from 49 deceased donors without known osteoarthritis …

se, ch (code pays fourni par la source)

Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage

Joonas P. Kosonen, Atte S. A. Eskelinen, Gustavo A. Orozco, Mitchell C. Coleman et autres

Joint trauma often leads to articular cartilage degeneration and post-traumatic osteoarthritis (PTOA). Pivotal determinants include trauma-induced excessive tissue strains that damage cartilage cells. As a downstream effect, these damaged cells can trigger cartilage degeneration via oxidative stress, cell death, and proteolytic tissue …

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FOREST TO FAÇADE: USING MASS TIMBER PANELS TO RETROFIT LOW-RISE COMMERCIAL BUILDINGS TO IMPROVE RESILIENCE

Mark Fretz, Gustavo A. Orozco, Andrew Loia, Jason Stenson et autres

Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage

Joonas P. Kosonen, Atte S. A. Eskelinen, Gustavo A. Orozco, Mitchell C. Coleman et autres

Abstract Joint trauma often leads to articular cartilage degeneration and post-traumatic osteoarthritis (PTOA). Pivotal determinants include trauma-induced excessive tissue strains that damage cartilage cells. As a downstream effect, these damaged cells can trigger cartilage degeneration via oxidative stress, cell death, and proteolytic …

fi, us (code pays fourni par la source)

Joint and tissue mechanics in post-traumatic osteoarthritis: insights from the rat model

Judith Piet, Amir Esrafilian, Seyed Ali Elahi, Falk Mielke et autres

Abstract Objective Altered mechanical loading is a known risk factor for osteoarthritis. Destabilization of the medial meniscus (DMM) is a preclinical gold standard model for post-traumatic osteoarthritis and is thought to induce instability and locally increased loading. However, the joint- and tissue-level …

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Effect of patient specificity on predicting knee cartilage degeneration in obese adults: Musculoskeletal finite‐element modeling of data from the CAROT trial

Gustavo A. Orozco, Lauri Stenroth, Amir Esrafilian, Petri Tanska et autres

Obesity is a known risk factor for development of osteoarthritis (OA). Numerical tools like finite-element (FE) models combined with degenerative algorithms have been developed to understand the interplay between OA and obesity. In this study, we aimed to predict knee cartilage degeneration …

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In Situ Loading and Time‐Resolved Synchrotron‐Based Phase Contrast Tomography for the Mechanical Investigation of Connective Knee Tissues: A Proof‐of‐Concept Study

Hector Dejea, Maria Pierantoni, Gustavo A. Orozco, E. Tobias B. Wrammerfors et autres

Articular cartilage and meniscus transfer and distribute mechanical loads in the knee joint. Degeneration of these connective tissues occurs during the progression of knee osteoarthritis, which affects their composition, microstructure, and mechanical properties. A deeper understanding of disease progression can be obtained …

se, ch (code pays fourni par la source)

Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines

Joonas P. Kosonen, Atte S. A. Eskelinen, Gustavo A. Orozco, Petteri Nieminen et autres

Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, …

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A systematic review of mathematical modeling for molecular distillation technologies

Ángela M. Idárraga-Vélez, Gustavo A. Orozco, Iván D. Gil

Molecular distillation is a separation technique used to separate thermosensible compounds. This process is often used to obtain concentrates of value-added products. For this reason, the research in this field has grown steadily during the past years. However, many efforts to simulate …

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Comparison of constitutive models for meniscus and their effect on the knee joint biomechanics during gait

Tulashi Simkheada, Gustavo A. Orozco, Rami Kristian Korhonen, Petri Tanska et autres

Mechanical behavior of meniscus can be modeled using constitutive material models of varying complexity, such as isotropic elastic or fibril reinforced poroelastic (FRPE). However, the FRPE material is complex to implement, computationally demanding in 3D geometries, and simulation is time-consuming. Hence, we …

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Multiscale In Silico Modeling of Cartilage Injuries

Rami Kristian Korhonen, Atte S. A. Eskelinen, Gustavo A. Orozco, Amir Esrafilian et autres

Injurious loading of the joint can be accompanied by articular cartilage damage and trigger inflammation. However, it is not well-known which mechanism controls further cartilage degradation, ultimately leading to post-traumatic osteoarthritis. For personalized prognostics, there should also be a method that can …

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SEISMIC AND ENERGY RETROFIT OF MULTIFAMILY LIGHT-FRAME TIMBER RESIDENTIAL BUILDINGS USING MASS PLY PANEL (MPP) WALL FAÇADE SYSTEM

Gustavo A. Orozco, André R. Barbosa, Mark Fretz, Judith Sheine et autres

The most common type of construction in the US for single and multifamily housing is known as Light-Wood-Frame (LWF).This system has been widely used for decades, following prescriptive design rules and usually without an engineered-based analysis.Due to the evolution of knowledge on …

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