Mitchell C. Coleman

Biomarkers of Injury Severity in Shoulder Instability and Posttraumatic Osteoarthritis

Patrick W. Rooney, Reilly Corken, Mark D Wishman, Cory Call et autres

» There is a poor understanding of the significance of biomarkers in the blood, synovial fluid, and tissue in patients with shoulder instability and posttraumatic osteoarthritis (PTOA). » Identification of biomarkers associated with injury severity in shoulder instability may provide prognostic information …

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A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture

Karen I. Cyndari, Jacob M. Elkins, Mitchell C. Coleman, KariAn E. Mulford et autres

Arthritis is an inflammatory state within joints resulting in cartilage damage, pain, and loss of mobility. Recent advances in arthritis research specifically demonstrate that the joint capsule (e.g., synovium) is an important source of this inflammation, but there are no human models …

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Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection

Abhishek Kumar Verma, L. K. Tan, Noah A. Schuster, Skyler L. Moye et autres

Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is poorly understood. Here, we report neurological dysfunction for at least 120 d postinfection in mice infected with a virulent nonneurotropic mouse-adapted SARS-CoV-2. …

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Metallosis Disrupts Bone Healing in Posterolateral Spinal Fusion: in Vivo Modeling of Metal Particle Effects on Fusion Integrity.

Jacob S Fisher, Mitchell C. Coleman, Douglas Fredericks, Cale Dobson et autres

Background: Metallosis is a known complication of joint arthroplasty, but its role in failures of spinal fusion procedures likely remains underrecognized. The release of metallic debris from implant interfaces may impair osteogenesis by triggering local inflammatory responses. To date, no in vivo …

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Targeting oxidative stress with amobarbital to prevent intervertebral disc degeneration: part II. Rabbit disc herniation model

Venkateswaran Ganesh, Douglas C. Fredericks, Mitchell C. Coleman, Emily Petersen et autres

BACKGROUND: Evidence that oxidative stress contributes to the progression of posttraumatic intervertebral disc degeneration suggests targeting oxidant metabolism in disc cells as a strategy to mitigate degeneration in injured discs. We previously identified amobarbital, a drug that suppresses mitochondrial activity in a …

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Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage

Joonas P. Kosonen, Atte S. A. Eskelinen, Gustavo A. Orozco, Mitchell C. Coleman et autres

Joint trauma often leads to articular cartilage degeneration and post-traumatic osteoarthritis (PTOA). Pivotal determinants include trauma-induced excessive tissue strains that damage cartilage cells. As a downstream effect, these damaged cells can trigger cartilage degeneration via oxidative stress, cell death, and proteolytic tissue …

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Carbon Monoxide Stimulates Chondrocyte Mitochondria and Protects Mitochondria During Cartilage Injury

Suryamin Liman, Madeline Hines, Piedad C. Gómez-Contreras, Emily Witt et autres

Objective: Joint injury precipitates post-traumatic osteoarthritis (PTOA) via chondrocyte mitochondrial oxidative damage. Carbon monoxide (CO) is a small molecule with potent antioxidant and mitochondrial benefits in other tissues that have not been explored in healthy chondrocytes. We hypothesized that CO would subvert …

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A review of periostin in orthopedics

Mark D Wishman, William M Sgrignoli, Brendan M. Patterson, James V. Nepola et autres

Objective: This review explores periostin (POSTN), a matricellular protein integral to developmental physiological, and pathological processes, by examining its structure, function, and emerging roles in orthopedic and non-musculoskeletal pathologies. It investigates POSTN's potential as a biomarker and therapeutic target in orthopedic diseases, …

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Glutathione Peroxidase 4 Overexpression Alters Bone Remodeling in response to Injury and Overloading

Madeline Hines, Suryamin Liman, Douglas C. Fredericks, Holly Van Remmen et autres

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Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis

Austin Scholp, Jordan A. Jensen, Timothy P. Fowler, Emily Petersen et autres

Elbow trauma can lead to joint contracture and reduced range of motion (ROM). Nonsurgical interventions can improve ROM, but in some cases capsule release surgery is required. Although surgery can improve ROM, it often does not restore full ROM. Thus, alternatives are …

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A reciprocal relationship between mitochondria and lipid peroxidation determines the chondrocyte intracellular redox environment

Madeline Hines, Piedad C. Gómez-Contreras, Suryamin Liman, Alexandria M. Wilson et autres

In orthopedic research, many studies have applied vitamin E as a protective antioxidant or used tert-butyl hydroperoxide to induce oxidative injury to chondrocytes. These studies often support the hypothesis that joint pathology causes oxidative stress and increased lipid peroxidation that might be …

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Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage

Joonas P. Kosonen, Atte S. A. Eskelinen, Gustavo A. Orozco, Mitchell C. Coleman et autres

Abstract Joint trauma often leads to articular cartilage degeneration and post-traumatic osteoarthritis (PTOA). Pivotal determinants include trauma-induced excessive tissue strains that damage cartilage cells. As a downstream effect, these damaged cells can trigger cartilage degeneration via oxidative stress, cell death, and proteolytic …

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