Vera Farah

Wistar rat as an animal model to study high-fat induced kidney damage: a systematic review

Renata O. Pereira, Luana A. Correia, Daniela Farah, Geovana Komoni et autres

The effects of high-fat-associated kidney damage in humans are not completely elucidated. Animal experiments are essential to understanding the mechanisms underlying human diseases. This systematic review aimed to compile evidence of the role of a high-fat diet during the development of renal …

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Reduction of oxidative stress and inflammatory signaling in the commissural nucleus of the solitary tract (commNTS) and rostral ventrolateral medulla (RVLM) in treadmill trained rats

H. Farah, Daniela Farah, Jonas Pereira Nunes, Cristiana A. Ogihara et autres

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Modulation of renin angiotensin system components by high glucose levels in the culture of collecting duct cells

Ana Paula de Oliveira Leite, Danielle Sanches Aragão, Marie Doki Nogueira, Renata O. Pereira et autres

Diabetes mellitus and its complications have become a major health concern in Western countries. Increased activity of the intrarenal renin-angiotensin system (RAS) contributes to diabetic nephropathy (DN). We previously reported that in mesangial cells, the high glucose concentration (HG) leads to upregulation …

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Post-weaning Exposure to High-Fat Diet Induces Kidney Lipid Accumulation and Function Impairment in Adult Rats

Cynthia R. Muller, Ana Paula de Oliveira Leite, Rodrigo Yokota, Renata O. Pereira et autres

Aim: We investigated the renal lipotoxicity in adult rats exposed to high-fat diet since post-weaning. Main Methods: Male Wistar rats were divided into two groups: ND (normal diet; n=10) and HD (high fat diet; n=10). The high fat diet was introduced post …

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Early consumption of high-fat diet worsens renal damage in spontaneously hypertensive rats in adulthood.

Renata O. Pereira, Cynthia R. Muller, Nilberto Robson Falcão do Nascimento, Manassés Claudino Fonteles et autres

and 88 ± 2 µm, respectively). HFD also showed a decrease of 50% of the renal function, which was associated with higher renal extracellular matrix and lipid deposition. Therefore, our data suggest that HFD since early period of life may contribute to …

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Intra-Renal Angiotensin Levels Are Increased in High-Fructose Fed Rats in the Extracorporeal Renal Perfusion Model

Rodrigo Yokota, Fernanda Aparecida Ronchi, Fernanda Barrinha Fernandes, Zaira Palomino Jara et autres

model of the role of the renin Angiotensin system (RAS) in the kidney. The use of perfused kidney from animals submitted to 8-week fructose treatment showed that high fructose intake caused metabolic and cardiovascular alterations that were consistent with other studies. Moreover, …

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A5890 Hemodynamic and inflammatory effects of an acute salt overload in hypertensive rats

Vera Farah, Renata O. Pereira, Marina Soares de Souza, Camila Paixão et autres

Objectives: The aim of this study was to evaluate the effects of an acute salt overload in hemodynamic and inflammatory cytokines of hypertensive rats. Methods: Male spontaneously hypertensive rats (SHR; 250–300 g) were divided into 2 groups (n = 6/group): SHR Control …

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Hyperlipidic diet induced glomerular morphometric alterations and renal damage in hypertensive rats

Renata O. Pereira, Marina Soares de Souza, Iara Cristina Araujo, Patrícia Fiorino et autres

The aim of this study was to evaluate the renal function in hypertensive hyperlipidic‐fed animals submitted to an acute NaCl overload. Weaned male spontaneously hypertensive rats (SHR) with 21 days old (40–50g) followed by 8 weeks, were divided into 4 groups (n=6/group): …

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Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

Daniela Farah, Jonas Pereira Nunes, Michelle Sartori, Danielle da Silva Dias et autres

The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in …

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Abstract P164: The Role of the Adrenoreceptors Beta 3 on Metabolic Syndrome Induced by Fructose

Eduardo P. Dias, Alexandre Tavolari, Marina Batista Chaves Azevedo de Souza, Renata Giudice de Oliveira et autres

The aim of this study was to evaluate the role of the adrenoreceptor beta 3 (ARβ3) in the cardiovascular function on Metabolic Syndrome (MS) induced by fructose overload. Male mice after weaning (8-10g) were divided into 4 groups (n=7/group): FVB Control (C) …

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Exposure to high-fat diet since post-weaning induces cardiometabolic damage in adult rats

Patrícia Fiorino, Anna Laura Viacava Américo, Cynthia R. Muller, Fabiana S. Evangelista et autres

AIMS: This study sought to investigate the metabolic, hemodynamic and autonomic responses in adult rats exposed to high-fat diet since post-weaning. MAIN METHODS: Young male Wistar rats were assigned into groups fed with standard normal diet (3% lipids; ND, n=8) or high-fat …

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Subclinical Renal Damage Induced by High-Fat Diet in Young Rats

Larissa M. Vargas, Julia M. Sacchi, Renata O. Pereira, Lucas S. Asano et autres