Ana Paula de Oliveira Leite

Estradiol is not protective against angiotensin II‐induced hypertension in middle‐aged ovariectomized rats

Ana Paula de Oliveira Leite, Isabela Pires dos Santos, Yan Zha, Sophia Blessinger et autres

Menopause leads to loss of cardiovascular and renal protection, and while hormone therapy offers benefits, its efficacy may depend on health status at menopause onset. We hypothesized that preexisting hypertension blunts the renal, cardiac, and vascular effects of Estradiol (E2). Female Long-Evans …

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Abstract TAC203: Estradiol Fails to Protect the Kidney and Vasculature When Hypertension Precedes Menopause

Ana Paula de Oliveira Leite, Hannah Petillo, Sophia Blessinger, Hannah Cheeran et autres

Menopause is associated with the loss of cardiovascular and renal protection, increasing the risk of hypertension and kidney disease. Although menopausal hormone therapy (MHT) offers multiple benefits, its effectiveness may depend on health status at the onset of menopause. Preexisting conditions such …

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Abstract TH181: Estrogen Loss and Sleep Restriction Disrupt Blood Pressure Rhythms and Vascular Function

Bruna Visniauskas, Sophia Blessinger, Chase Richard, Ana Paula de Oliveira Leite et autres

Inadequate sleep disrupts circadian clock function and impacts blood pressure (BP) diurnal rhythms, contributing to increased cardiovascular risk. Sleep disturbances are common during menopause, but whether they worsen menopause-associated BP dysregulation remains unclear. To address this, we examined how sleep restriction (SR) …

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The Benefits of Estradiol on Cognitive Aging in Rats Are Independent From Its Effects on Cardiometabolic Health

Christian Montanari, Emma L Dong, Shruti Srinivasan, Ana Paula de Oliveira Leite et autres

Research in preclinical models of menopause indicates that exogenously administered estrogens positively affect cognitive aging. However, clinical evidence indicates that the effects of estrogen therapy on cognition are inconsistent and may be modulated by preexisting cardiometabolic conditions. The extent to which cardiometabolic …

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PAX4 mody - a novel variant

João Menino, Patrı́cia Ferreira, Inês Meira, Ana Paula de Oliveira Leite et autres

The benefits of estradiol on cognitive aging in rats are independent from its effects on cardiometabolic health

Christian Montanari, Emma L Dong, Shruti Srinivasan, Ana Paula de Oliveira Leite et autres

Abstract Research in preclinical models of menopause indicates that exogenously administered estrogens positively impact cognitive aging. However, clinical evidence indicates that the effects of estrogen therapy on cognition are inconsistent and may be modulated by pre-existing cardiometabolic conditions. The extent to which …

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Abstract P435: PROTEIN KINASE MODULATION IN THE INVESTIGATION OF ANGIOTENSIN-CONVERTING ENZYME AS A SIGNALING PATHWAY.

Rodrigo Yokota, Ana Paula de Oliveira Leite, Lilian Caroline Gonçalves de Oliveira, Andréia Cristina Febba Gomes et autres

The Renin-Angiotensin System (RAS) is a hormonal cascade intricately involved in regulating hydro electrolyte homeostasis and blood pressure control. The Angiotensin II peptide (ANGII) is the main and most potent biologically active product within this system, which is produced by the action …

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Abstract P144: Estrogen Worsens Kidney Function in Hypertensive Menopausal Rats

Ana Paula de Oliveira Leite, Hannah Petillo, Sophia Blessinger, Jill M. Daniel et autres

Introduction: Before menopause, women generally have lower rates of hypertension and cardiovascular events compared with men. After menopause, women lose significant cardiovascular and renal protection. Estrogen's effect on kidney function is controversial, with some studies showing protection and others, including ours, indicating …

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Dimethyl Fumarate Mediates Sustained Vascular Smooth Muscle Cell Remodeling in a Mouse Model of Cerebral Aneurysm

Alejandra N. Martinez, Giovane G. Tortelote, Crissey L. Pascale, Uduak-Obong I. Ekanem et autres

Cerebral aneurysms (CA) are a type of vascular disease that causes significant morbidity and mortality with rupture. Dysfunction of the vascular smooth muscle cells (VSMCs) from circle of Willis (CoW) vessels mediates CA formation, as they are the major cell type of …

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Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases

Sarah M. Nwia, Ana Paula de Oliveira Leite, Xiao‐Chun Li, Jia L. Zhuo

Cardiovascular disease is a pathology that exhibits well-researched biological sex differences, making it possible for physicians to tailor preventative and therapeutic approaches for various diseases. Hypertension, which is defined as blood pressure greater than 130/80 mmHg, is the primary risk factor for …

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Differences and the impact of G protein-coupled estrogen receptor deletion in the vascular and renal response to aldosterone

Ana Paula de Oliveira Leite, Ben Ogola, Bruna Visniauskas, Isabella Kilanowski‐Doroh et autres

We recently showed that the G protein-coupled estrogen receptor (GPER) protects female mice from arterial stiffening, an independent predictor of cardiovascular mortality. Previous work indicates that GPER may directly bind aldosterone and/or dimerize with the mineralocorticoid receptor. Therefore, we hypothesized that GPER …

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Supplementary Table 1 from A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma

Maria Dvorkina, Valentina Nieddu, Shalini Chakelam, Annalisa Pezzolo et autres

Correlation of PML expression with tumor relapse/outcome in localised and metastatic tumours (Gaslini and first ICH/GOSH cohort)