Linxi Li

Detection of Myoglobin Gene Polymorphism Associated With Pigeons' Growth Traits

Zengguang Liao, Shudai Lin, Sadaqat Ali, Junyuan Lin et autres

ABSTRACT Utilizing single nucleotide polymorphism (SNP) genotyping techniques to select animals with high economic trait values, including reproduction and growth, have attracted great attention. Myoglobin (Mb) is a cytoplasmic hemoprotein involved in oxygen transport and storage, and plays a critical role in …

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Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+

Chulei Cao, Jie Yang, Weizhen Zhang, Jiaqin Chen et autres

Tpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO42- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of tRNA. In …

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An LLC Resonant Converter With Reconfigurable Secondary-Bridge With Wide Output Voltage Range

Samuel S. Queiroz, Linxi Li, Levy F. Costa

This paper introduces a novel reconfigurable LLC resonant converter using a center-tapped transformer and an adaptive turns ratio approach for output voltage regulation. The proposed topology achieves dynamic voltage gain adjustment by modifying the transformer turns ratio through a unidirectional secondary-side switch. …

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CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway

Linxi Li, Anju Zuo, Ruoyu Yin, Qiangqiang Liu et autres

Sarcopenia, a degenerative condition marked by progressive skeletal muscle atrophy and impaired regeneration, is closely associated with aging, chronic inflammation, and disrupted proteostasis. While macroautophagy has been extensively studied in this context, little of the role of chaperone-mediated autophagy (CMA) has been …

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Structural and functional studies of the main replication protein NS1 of human parvovirus B19

Yixi Zhang, Boming Fan, Yanqing Gao, Jie Yang et autres

Parvovirus B19 (B19V) is a ubiquitous virus that can infect the majority of human population and cause erythema infectiosum, acute arthropathy, and many other diseases. The main replication protein NS1 plays a critical role in cell cycle arrest, transactivation of viral and …

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C1q/TNF-related protein-9 promotes diabetic wound healing by enhancing dendritic cell efferocytosis via the ATF3/SLC7A11 signaling axis

Shaomeng Zhang, Linxi Li, Jiarui Li, Shiyan Ruan et autres

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Azole fungicides: Potential endocrine disrupting effects and impact on placental steroidogenesis via inhibiting human and rat 3β-hydroxysteroid dehydrogenase

Jingyun Yan, Huan Chen, Zhongyao Ji, Yunbing Tang et autres

indicated that lipophilicity enhances inhibitory efficacy. 3D-QSAR analysis further confirmed the critical role of hydrogen bonding in binding affinity. In conclusion, climbazole exhibits the strongest inhibition of human 3β-HSD1, driven by its high lipophilicity. These findings highlight the endocrine-disrupting potential of azole …

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Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer’s disease therapeutics

Zhixin Xie, Linxi Li, Weizhong Hou, Zhongxi Fan et autres

BACKGROUND: Alzheimer's disease (AD) has a significant impact on an individual's health and places a heavy burden on society. Studies have emphasized the importance of microglia in the progression and development of AD. Interferon responses and Interferon-stimulated genes (ISGs) significantly function in …

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Corrigendum to “Microglia-mediated pericytes migration and fibroblast transition via S1P/S1P3/YAP signaling pathway after spinal cord injury” [Vol. 379 of Experimental Neurology (September 2024)]

Ziyuan Yu, Huabin Zhang, Linxi Li, Zhi Li et autres

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Regulation of Proanthocyanidin Accumulation by Vvmyb1 in Response to Vine Water Constraint in 'Marselan' Grape Berries

Xiaobin Xue, Chenyang Hou, Pengcheng Yang, Hongsheng Hu et autres

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Microtubule-Associated Proteins (MAPs) Are Multifunctional Cytoskeletal Proteins in the Testis That Regulate Spermatogenesis

Lingling Wang, Tiao Bu, Xiaolong Wu, Sheng Gao et autres

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Interacting Fat1 and Dchs Planar Cell Polarity Proteins Supported by Fjx1 Serve as Heterodimeric Intercellular Bridges Crucial to Support Spermatogenesis

Tiao Bu, Lingling Wang, Xiaolong Wu, Sheng Gao et autres

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