Taylan Kav

Management of Refractory and Difficult‐To‐Treat Inflammatory Bowel Disease: An Expert Opinion Review

Filiz Akyüz, Oğuz Kağan Bakkaloğlu, Nalan Gülşen Ünal, İsmail Hakkı Kalkan et autres

ABSTRACT The management of refractory and difficult‐to‐treat inflammatory bowel disease (IBD) poses significant challenges, requiring a personalized, treat‐to‐target approach. Refractory IBD is defined as persistent or worsening disease despite all classes of licensed immunosuppressive and biologic agents, with additional criteria for Crohn's …

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Efficacy and Safety of Temporary Fully Covered Self-Expandable Metal Stents for High-Grade Biliary Strictures in Primary Sclerosing Cholangitis: A Single-Center Retrospective Case Series

Yavuz Emre Parlar, Bengi Öztürk, Beyza Atay, Onur Keskin et autres

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Crohn hastalarında cerrahi gereksinimini öngören klinik faktörlerin değerlendirilmesi: Tek merkez deneyimi

Bengi Öztürk, Ibrahim Nahit Sendur, Muhammet Furkan Cakmak, Taylan Kav

Giriş ve Amaç: Crohn hastalığında cerrahi gereksinimi, hastalık prognozunu ve yaşam kalitesini önemli ölçüde etkileyen temel klinik sonlanımlardan biridir. Cerrahi gereksinimini öngören risk faktörlerinin belirlenmesi, yüksek riskli hastaların erken tanınmasına ve uygun tedavi stratejilerinin geliştirilmesine katkı sağlayabilir. Bu çalışmada, Crohn hastalarında majör …

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Evaluation of clinical factors predicting the need for surgery in patients with Crohn’s disease: Single center experience

Bengi Öztürk, Ibrahim Nahit Sendur, Muhammet Furkan Cakmak, Taylan Kav

Giriş ve Amaç: Crohn hastalığında cerrahi gereksinimi, hastalık prognozunu ve yaşam kalitesini önemli ölçüde etkileyen temel klinik sonlanımlardan biridir. Cerrahi gereksinimini öngören risk faktörlerinin belirlenmesi, yüksek riskli hastaların erken tanınmasına ve uygun tedavi stratejilerinin geliştirilmesine katkı sağlayabilir. Bu çalışmada, Crohn hastalarında majör …

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Upadacitinib as a rescue therapy for steroid- and infliximab-refractory acute severe ulcerative colitis: short- and long-term effectiveness and safety in a multicenter cohort study

Nalan Gülşen Ünal, Oğuz Kağan Bakkaloğlu, Taylan Kav, Tuğçe Eşkazan et autres

BACKGROUND: Acute severe active ulcerative colitis (ASUC) often requires rescue therapy when standard medical treatment fails. Data on the use of upadacitinib (UPA) as a rescue option after failure of steroids and infliximab (IFX) and on the long-term outcomes of UPA treatment …

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FRI-231 Clinical determinants of survival beyond two years in HCC patients receiving non-curative treatment

Burcu Gürbüz, Mustafa Utku Maraşlı, Hasan Sahin, Muhammet Furkan Cakmak et autres

WED-464 Comparative prognostic performance of MELD-based and GEMA scores: a real-world cohort study

Furkan Kabukcu, Burcu Gürbüz, Hakan Oral, İbrahim Nahit Şendur et autres

Prognostic Significance of Cystic Biliary Dilatation in Primary Sclerosing Cholangitis

Yavuz Emre Parlar, Bengi Öztürk, Onur Keskın, Sabir İsrafilov et autres

Background/Aims: Primary sclerosing cholangitis (PSC) is a chronic, progressive disease characterized by inflammatory and fibrotic strictures in the intrahepatic and/or extrahepatic bile ducts. Typical cholangiographic findings include multifocal, annular, short bile duct strictures with minimal upstream dilatation. However, in some patients, this …

Prognostic Significance of Cystic Biliary Dilatation in Primary Sclerosing Cholangitis

Yavuz Emre Parlar, Bengi Öztürk, Onur Keskin, Sabir İsrafilov et autres

Background/Aims: Primary sclerosing cholangitis (PSC) is a chronic, progressive disease characterized by inflammatory and fibrotic strictures in the intrahepatic and/or extrahepatic bile ducts. Typical cholangiographic findings include multifocal, annular, short bile duct strictures with minimal upstream dilatation. However, in some patients, this …

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Sleep impairment in patients with ulcerative colitis: a cross-sectional assessment of clinical, inflammatory, metabolic and behavioral factors

Yunus GÜNEGÜL, Onur Keskin, Taylan Kav

BACKGROUND: Sleep impairment is common in ulcerative colitis (UC) and may persist during clinical remission. This study evaluated the clinical, inflammatory, metabolic, and behavioral features to better characterize the factors associated with poor sleep in patients with UC. METHODS: A cross-sectional study …

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Five-year efficacy and safety of guselkumab for moderately to severely active Crohn’s disease: Results from the phase 2 GALAXI 1 trial

Anita Afzali, Silvio Danese, Remo Panaccione, David T Rubin et autres

BACKGROUND: The randomized, phase 2 GALAXI 1 study evaluated efficacy and safety of guselkumab, a dual-acting IL-23p19 subunit inhibitor, in participants with moderately to severely active Crohn's disease. Efficacy and safety through 5 years are reported. METHODS: After completing the 48-week, treat-through …

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Endoscopic Transpapillary Gallbladder Drainage Reduces the Frequency of Biliopancreatic Events in the Waiting Period for Surgery, Even in Patients without Comorbid Diseases

Yavuz Emre Parlar, Bengi Öztürk, Onur Keskin, Taylan Kav et autres

INTRODUCTION: In patients with acute cholecystitis and choledocholithiasis undergoing endoscopic retrograde cholangiopancreatography (ERCP) followed by interval cholecystectomy (6 weeks-3 months), preoperative biliopancreatic events are reported in 18.3-41.8%. Endoscopic transpapillary gallbladder drainage (ET-GBD) is indicated in this patient group if there are comorbidities …

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