A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine
Rattachement africain : tr, mx, sk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Inhibiting aldose reductase (ALR2, AR) as well as maintaining a concomitant antioxidant (AO) activity via dual-acting agents may be a rational approach to prevent cellular glucotoxicity and at least delay the progression of diabetes mellitus (DM). This study was aimed at evaluating the dual-acting AR inhibitor (ARI) cemtirestat (CMTI) on tissue oxidative stress (OS) and carbonyl stress (CS) biomarkers in rats exposed to fructose alone (F) or fructose plus streptozotocin (D; type-2 diabetic). D and F rats were either untreated or treated daily with low- or high-dose CMTI, ARI drug epalrestat (EPA) or antioxidant stobadine (STB) for 14 weeks. Malondialdehyde (MDA), glutathione S-transferase (GST), nitric oxide synthase (NOS), and catalase (CAT) were increased in the sciatic nerve of F and D. These increases were attenuated by low doses of CMTI and STB in D, but exacerbated by low-dose EPA and high-dose CMTI in F. STB and CMTI and to a lesser extent EPA improved MDA, protein-carbonyl, GST and CAT in the hearts and lungs of F and D. CMTI and STB were more effective than EPA in improving the increased MDA and protein-carbonyl levels in the kidneys of F and especially D. CMTI ameliorated renal GST inhibition in D. In the lungs, hearts, and kidneys of F and D, the GSH to GSSG ratio decreased and caspase-3 activity increased, but partially resolved with treatments. In conclusion, CMTI with ARI/AO activity may be advantageous in overcoming OS, CS, and their undesirable consequences, with low dose efficacy and limited toxicity, compared to ARI or antioxidant alone.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine
- Date Crossref
- 05/10/2023
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Bayburt University Department of Medical Services and Techniques pays non établi dans la noticeUniversité ou école supérieure
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Ankara Yıldırım Beyazıt University pays non établi dans la noticeUniversité ou école supérieure
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Gazi University pays non établi dans la noticeUniversité ou école supérieure
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Instituto Nacional de Neurología y Neurocirugía Laboratorio de Aminoácidos Excitadores/Laboratorio de Neurofarmacología Molecular y Nanotecnología pays non établi dans la noticeStructure de recherche
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Slovak Academy of Sciences pays non établi dans la noticeOrganisme public
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Centre of Experimental Medicine of the Slovak Academy of Sciences pays non établi dans la noticeStructure de recherche
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Faculty of Medicine Department of Medical Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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Institute of Experimental Pharmacology & Centre of Experimental Medicine pays non établi dans la noticeStructure de recherche
Department of Medical Services and Techniques — Bayburt University, Ankara Yıldırım Beyazıt University et Gazi University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.