Christine Péchoux

Inhibiting the fructose transporter GLUT5 boosts testosterone production in a murine mLTC-1 leydig cell line

Aikaterini Kallianioti, Guillaume Bourdon, Claire Chevaleyre, Christine Péchoux et autres

fr, in, Maroc (code pays fourni par la source)

The great phage escape: Activating and escaping lactococcal antiphage systems

Cas Mosterd, Andriana Grafakou, Guillermo Ortíz Charneco, Paul P. de Waal et autres

In recent years, the number of newly discovered systems that bacteria use to combat bacteriophages is increasing at an impressive rate. To obtain mechanistic insights into several antiphage systems identified in previous studies, we isolated 66 phage escape mutants which had become …

ie, ch, ca, fr (code pays fourni par la source)

Mice Lacking the Fructose Transporter Glut5 Exhibit Excessive Androgens and Reduced Sperm Motility

Aikaterini Kallianioti, Guillaume Bourdon, Jérémy Grandhaye, Claire Chevaleyre et autres

Overconsumption of fructose is linked to metabolic diseases, which are often associated with reduced fertility. GLUT5 is the most specific fructose transporter. To investigate its role in the testes, we analyzed the male reproductive phenotype of transgenic male mice deficient in GLUT5 …

fr (code pays fourni par la source)

Human ovarian extracellular vesicles proteome from polycystic ovary syndrome patients associate with follicular development alterations

Noémie Couty, Anthony Estienne, Soazig Le Lay, Christelle Ramé et autres

The development of the ovarian follicle requires the presence of several factors that come from the blood and follicular cells. Among these factors, extracellular vesicles (EVs) represent an original communication pathway inside the ovarian follicle. Recently, EVs have been shown to play …

fr (code pays fourni par la source)

Complex sporulation-specific expression of transcription termination factor Rho highlights its involvement in Bacillus subtilis cell differentiation

Vladimir Bidnenko, Arnaud Chastanet, Christine Péchoux, Yulia Redko-Hamel et autres

Termination factor Rho, responsible for the main factor-dependent pathway of transcription termination and the major inhibitor of antisense transcription, is an emerging regulator of various physiological processes in microorganisms. In Gram-positive bacterium Bacillus subtilis, Rho is involved in the control of cell …

fr (code pays fourni par la source)

Massive detection of cryptic recessive genetic defects in dairy cattle mining millions of life histories

F. Besnard, Ana Guintard, Cécile Grohs, Laurence Guzylack‐Piriou et autres

BACKGROUND: Dairy cattle breeds are populations of limited effective size, subject to recurrent outbreaks of recessive defects that are commonly studied using positional cloning. However, this strategy, based on the observation of animals with characteristic features, may overlook a number of conditions, …

fr (code pays fourni par la source)

The hepatokine FGF21 stopped lipogenesis and reduced testosterone production in mLTC-1 Leydig Cell Line

Guillaume Bourdon, Claire Chevaleyre, Anthony Estienne, Christine Péchoux et autres

Beyond their link to metabolic issues like type 2 diabetes, factors like lifestyle, environment, and excess weight may also influence fertility. Fibroblast growth factor 21 (FGF21), a liver-derived hormone linked to energy balance, has recently emerged as a potential player in female …

fr (code pays fourni par la source)

Mutation of SOCS2 induces structural and functional changes in mammary development

Elitsa Ivanova, Cathy Hue‐Beauvais, Johan Castille, Johann Laubier et autres

Lactation is an essential process for mammals. In sheep, the R96C mutation in suppressor of cytokine signaling 2 (SOCS2) protein is associated with greater milk production and increased mastitis sensitivity. To shed light on the involvement of R96C mutation in mammary gland …

fr (code pays fourni par la source)

Complex sporulation-specific expression of transcription termination factor Rho highlights its involvement in Bacillus subtilis cell differentiation

Vladimir Bidnenko, Arnaud Chastanet, Christine Péchoux, Yulia Redko-Hamel et autres

Abstract Transcription termination factor Rho controls pervasive, mainly antisense, transcription initiated at cryptic signals or resulting from read-through at weak terminators in various bacterial species. In Bacillus subtilis , Rho is intricately involved in the regulation of phenomena associated with the adaptation …

fr (code pays fourni par la source)

Massive detection of cryptic recessive genetic defects in cattle mining millions of life histories

F. Besnard, Ana Guintard, Cécile Grohs, Laurence Guzylack‐Piriou et autres

Abstract We present a data-mining framework designed to detect recessive defects in livestock that have been previously missed due to a lack of specific signs, incomplete penetrance, or incomplete linkage disequilibrium. This approach leverages the massive data generated by genomic selection. Its …

fr (code pays fourni par la source)

Molecular mechanisms underlying the structural diversity of complex rhamnose-rich cell wall polysaccharides in lactococci

H. Guérin, Pascal Courtin, Alain Guillot, Christine Péchoux et autres

International audience

fr, ca, ie (code pays fourni par la source)

Complex spatiotemporal expression of termination factor Rho highlights its involvement in spore morphogenesis and revival in Bacillus subtilis

Vladimir Bidnenko, Arnaud Chastanet, Christine Péchoux, Yulia Redko-Hamel et autres

International audience

fr (code pays fourni par la source)