Johannes Backs

HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity

Benay Eksi, Daniel Finke, Synje Michel, Jannek Brauer et autres

Anthracycline-induced cardiotoxicity remains a major limitation of cancer therapy, and effective preventive strategies are lacking. Topoisomerase IIb has been implicated as a central driver of this toxicity, suggesting that epigenetic regulators may interfere with the pathological cardiac response. Here, we show that …

de, us (code pays fourni par la source)

Childhood adversity and increased cytokine release from peripheral mononuclear cells of CHD patients – a pilot study

Henning Wiche, Ole Anhuef, Stefanie Martinache, Joe J. Simon et autres

BACKGROUND: Early life stress (ELS) is a risk factor for cardiovascular disease. Chronic low-grade inflammation has been linked to cardiovascular vulnerability. The interplay of ELS and inflammation in the context of coronary heart disease (CHD) remains elusive and was investigated in this …

de (code pays fourni par la source)

FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling

Frauke Senger, Susanne S. Hille, Anca Kliesow Remes, Tapan Kumar Baral et autres

Abstract Acute myocardial infarction (MI) is associated with severe metabolic and oxidative stress that triggers cardiomyocyte death, pro-inflammatory signaling and progressive structural remodeling frequently culminating in heart failure. Although significant advances in reperfusion therapy improved acute survival in patients, therapeutic strategies that …

de (code pays fourni par la source)

Class IIa HDACs Inhibition reverses diastolic dysfunction and Increase Energy Expenditure in a murine HFpEF model

Harikrishnareddy Paluvai, J Huang, A Saadatmand, Matthias Dewenter et autres

Abstract Heart failure (HF) with preserved ejection fraction (HFpEF) is the most rapidly growing cardiovascular disease worldwide, affecting up to 30 million people. New research suggest that histone deacetylases (HDACs) play a significant role in escalating HFpEF pathogenesis and enzymatic inhibition of …

de, it (code pays fourni par la source)

CAMK2D underlies cardiac dysfunction in RBM20 cardiomyopathy

Maarten van den Hoogenhof, Matthias Dewenter, Thiago Britto-Borges, Javier Duran et autres

de, sk, us, es (code pays fourni par la source)

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming

Yinuo Wang, Haojie Shi, Janina Wittig, Yonggang Ren et autres

Spatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here we identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity. Its loss in naive …

de, us (code pays fourni par la source)

Genomic G quadruplexes regulate mRNA splicing

Victoria Mauz, Thiago Britto‐Borges, Tobias S. Merkel, Enio Gjerga et autres

Abstract Genomic G quadruplexes (G4) are non-canonical DNA structures that regulate gene expression primarily through transcriptional control. Here, we uncover that DNA G quadruplexes are critical determinants of pre-mRNA splicing. G4s on the DNA template strand serve as recruiting elements for the …

de, us (code pays fourni par la source)

Metabo-epigenetic circuits of heart failure: chromatin-modifying enzymes as determinants of metabolic plasticity

Mark E. Pepin, Xuemin Gong, Almut Schulze, Johannes Backs

Metabolic adaptations are a functional requirement for the heart to accommodate its broad range of physiologic operating conditions. It is increasingly recognized that persistent and exaggerated metabolic alterations precede adverse cardiac remodeling leading to heart failure. These metabolic shifts are coupled with …

de, us (code pays fourni par la source)

Abstract 4339547: Nicotinamide Nucleoside Transhydrogenase (NNT) loss-of-function attenuates oxidative stress-associated myocardial fibrosis and diastolic dysfunction in cardiometabolic HFpEF

Mark E. Pepin, Philipp Konrad, Farhad Bazgir, Christoph Maack et autres

Background: The absence of effective, disease-modifying therapies continues to limit clinical management of cardiometabolic heart failure with preserved ejection fraction (cHFpEF). Although the “two-hit” murine model of high-fat diet and 0.5% N(ω)-nitro-L-arginine methyl ester (HFD+L-NAME) has been heralded as a reproducible model …

us, de (code pays fourni par la source)

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction

Alireza Saadatmand, Mark E. Pepin, Zihao Chen, Joshua Hartmann et autres

Abstract Heart failure with reduced ejection fraction (HFrEF) is marked by a shift in cardiac energy metabolism from fatty acid oxidation to glucose utilization. This “fuel switch” promotes accumulation of glucose byproducts that modify calcium-handling proteins and impair cardiac function, yet the …

de, us (code pays fourni par la source)

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsense-mediated mRNA degradation

Harikrishnareddy Paluvai, Mark E. Pepin, Friederike C. Schreiter, Alireza Saadatmand et autres

Abstract Histone deacetylases (HDACs) are essential chromatin regulators and are involved in the regulation of gene expression by removing acetyl groups from histone and non-histone proteins. Histone deacetylase 4 (HDAC4) is known to regulate the process of endochondral ossification in mice by …

de, co, us (code pays fourni par la source)

Adipokine–Cardiomyocyte Crosstalk

Norbert Frey, Johannes Backs

de, us (code pays fourni par la source)