Multifunctional Metal Polyphenol Nanoparticles Based on Photothermal Therapy for Bacterial Eradication and Wound Healing
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Le résumé fourni par la source
Balancing short-term antibacterial needs with long-term anti-inflammatory effects remains a major challenge in wound healing. Multifunctional bioactive materials capable of both efficient antibacterial action and inflammation modulation represent a promising solution. However, the majority of traditional antibacterial biomaterials possess only a single antibacterial effect, and their synthesis and preparation are intricate, which might restrict their clinical transformation. Chlorogenic acid is a natural compound endowed with anti-inflammatory properties. However, it is beset by certain inherent drawbacks, including poor water solubility and limited bioavailability. To overcome these difficulties, we have fabricated multifunctional nanoparticles (chlorogenic acid–iron nanoparticles, CA-Fe NPs) through the co-assembly of chlorogenic acid and iron ions in a straightforward manner. We found that CA-Fe NPs exhibit excellent photothermal conversion performance in vitro. Upon near-infrared (NIR) irradiation, they exhibit potent broad-spectrum antimicrobial activity against Staphylococcus aureus , Escherichia coli , Candida albicans , Klebsiella pneumoniae , and Pseudomonas aeruginosa . The CA-Fe NPs markedly reduced H 2 O 2 -induced reactive oxygen species levels and apoptosis in epithelial cells and suppressed lipopolysaccharide-induced M1 macrophage polarization in RAW 264.7 cells. Transmission electron microscopy results revealed enhanced bacterial membrane disruption by CA-Fe NPs under NIR irradiation, causing pronounced protein leakage. Transcriptomic analysis indicates that CA-Fe NPs combined with NIR disrupt the tricarboxylic acid cycle, cell-wall organization, and other metabolic processes. In vivo, within a methicillin-resistant Staphylococcus aureus -infected skin wound model, CA-Fe NPs maintained photothermal efficacy, effectively reduced serum levels of interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha, and accelerated wound healing. These findings suggest that CA-Fe NPs are multifunctional materials with broad-spectrum bactericidal ability, antioxidant, anti-inflammatory, and wound-healing-promotion properties. These nanoparticles possess promising prospects for biomedical applications.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multifunctional Metal Polyphenol Nanoparticles Based on Photothermal Therapy for Bacterial Eradication and Wound Healing
- Date Crossref
- 01/01/2026
- Éditeur
- American Association for the Advancement of Science (AAAS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangdong Pharmaceutical University Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations pays non établi dans la noticeUniversité ou école supérieure
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Southern University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Southern Medical University Shenzhen Hospital pays non établi dans la noticeÉtablissement de santé
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Shenzhen Second People's Hospital pays non établi dans la noticeÉtablissement de santé
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Southern Medical University pays non établi dans la noticeUniversité ou école supérieure
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Kunming University of Science and Technology Center for Translational Research in Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Kunming Medical University pays non établi dans la noticeUniversité ou école supérieure
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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China Academy of Chinese Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Shandong Academy of Chinese Medicine pays non établi dans la noticeStructure de recherche
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Shenzhen People's Hospital (The Second Clinical Medical College Department of Clinical Laboratory pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Screening pays non établi dans la noticeUniversité ou école supérieure
Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations — Guangdong Pharmaceutical University, Southern University of Science and Technology et Southern Medical University Shenzhen Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.