Alessandra Righetti

Structural basis of Nuclear Factor 1-X DNA recognition provides prototypic insight into the NFI family

Michele Tiberi, Michela Lapi, Louise J. Gourlay, Antonio Chaves-Sanjuán et autres

Nuclear Factor I (NFI) proteins are involved in adenovirus DNA replication and regulate gene transcription, stem cell proliferation, and differentiation. They play key roles in development, cancer, and congenital disorders. Within the NFI family, NFI-X is critical for neural stem cell biology, …

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Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis

Monia Cecati, Matteo Giulietti, Alessandra Righetti, Berina Šabanović et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of death among cancers, it is characterized by poor prognosis and strong chemoresistance. In the PDAC microenvironment, stromal cells release different extracellular components, including CXCL12. The CXCL12 is a chemokine promoting the …

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CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

Alessandra Righetti, Matteo Giulietti, Berina Šabanović, Giulia Occhipinti et autres

CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the …

Clinical impact of different exosomes’ protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy

Riccardo Giampieri, Francesco Piva, Giulia Occhipinti, Alessandro Bittoni et autres

INTRODUCTION: Pancreatic ductal adenocarcinoma is associated to dismal prognosis despite the use of palliative chemotherapy, partly due to the lack of knowledge of biological processes underlying disease progression. Exosomes have been identified as biomarkers sources in different cancer types. Aim of the …

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Emerging Biomarkers in Bladder Cancer Identified by Network Analysis of Transcriptomic Data

Matteo Giulietti, Giulia Occhipinti, Alessandra Righetti, Massimo Bracci et autres

Bladder cancer is a very common malignancy. Although new treatment strategies have been developed, the identification of new therapeutic targets and reliable diagnostic/prognostic biomarkers for bladder cancer remains a priority. Generally, they are found among differentially expressed genes between patients and healthy …

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To accelerate the Zika beat: Candidate design for RNA interference-based therapy

Matteo Giulietti, Alessandra Righetti, L. Cianfruglia, Berina Šabanović et autres

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LncRNA co-expression network analysis reveals novel biomarkers for pancreatic cancer

Matteo Giulietti, Alessandra Righetti, Giovanni Principato, Francesco Piva

High mortality and low survival rates for pancreatic ductal adenocarcinoma (PDAC) mainly result from the delay in diagnosis and treatment. Therefore, there is an urgent need to identify early PDAC biomarkers and new therapeutic targets. In this study, we applied a commonly …

Usi tradizionali e nuovi impieghi terapeutici di Atropa belladonna L.

Alessandra Righetti

Il tema centrale della tesi è la trattazione degli utilizzi tradizionali di Atropa belladonna L. lungo un percorso che porta all'esame dei suoi più recenti impieghi in campo terapeutico e diagnostico