Glen M. Boyle

Inhibition of BRN2 in melanoma reverses anoikis resistance and sensitizes cells to killing by vemurafenib

Hannah M. Neuendorf, Heping Xie, Mark N. Adams, Sharon Chow et autres

Abstract Anoikis is an apoptotic cell death program triggered upon detachment from surrounding extracellular structures. However, the ability to evade cell death by anoikis in the presence of apoptosis-inducing stimuli is necessary for the formation of malignant tumors and progression to metastasis. …

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A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma

Yuntian Zhang, Marcus Urquijo, Rebecca G. Zitnay, R.L. Belote et autres

Metastatic spread and therapeutic resistance are the principal causes of cancer mortality. For melanoma, these processes rely on the capacity of cells to switch between transcriptional states. Although targeting transcriptional states pharmacologically is promising, the mechanisms by which melanoma cells switch between …

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Pathogenesis of polypropylene mesh complications in female pelvic floor surgery

Christopher Maher, Ellen Yeung, Zhuoran Chen, Andrew Masel et autres

BACKGROUND: The pathogenesis of female pelvic floor polypropylene mesh complications is unclear, as trials evaluating explanted mesh have not included asymptomatic controls. OBJECTIVE: This study aimed to compare women undergoing ex-plantation of polypropylene mesh with and without complications to determine the pathogenesis …

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Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal Adenocarcinomas

Vanessa Lakis, Noni Chan, Ruth J. Lyons, Nicola Blackburn et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a high incidence of perineural invasion (PNI), a pathological feature of the cancer invasion of nerves. PNI is associated with a poor prognosis, local recurrence and cancer pain. It has been suggested that interactions between nerves …

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Spatial Transcriptomics of Perineural Invasion in Pancreatic Ductal Adenocarcinomas

Kátia Nones, Vanessa Lakis, Noni Chan, Ruth J. Lyons et autres

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Epoxytiglianes induce keratinocyte wound healing responses via classical protein kinase C activation to promote skin re-epithelialization

Rachael L. Moses, Emma L. Woods, Jordanna Dally, Jenny Johns et autres

Epoxytiglianes are a novel class of diterpene esters. The prototype epoxytigliane, EBC-46 (tigilanol tiglate), is a potent anti-cancer agent in clinical development for local treatment of a range of human and animal tumors. EBC-46 also consistently promotes wound re-epithelialization at the treatment …

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DIY.09 ELECTRICAL IMPEDANCE TOMOGRAPHY AND VENTILATOR DATA INTEGRATION FOR VENTILATION STRATEGY OPTIMIZATION IN MECHANICALLY VENTILATED PATIENTS

P. Ravese, Glen M. Boyle, I. Martin-Loeches

625 Environmentally stressed drug-naïve melanoma cell subpopulations share a molecular signature with drug-induced early persister cells

S. Asgharzadeh Kangachar, F. Hafna Ahmed, A. Al Emran, Glen M. Boyle et autres

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Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade

Jason K. Cullen, Pei-Yi Yap, Blake Ferguson, Zara C. Bruce et autres

BACKGROUND: Tigilanol tiglate (TT) is a protein kinase C (PKC)/C1 domain activator currently being developed as an intralesional agent for the treatment of various (sub)cutaneous malignancies. Previous work has shown that intratumoral (I.T.) injection of TT causes vascular disruption with concomitant tumor …

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seco-1-Azacubane-2-carboxylic Acid: Derivative Scope and Comparative Biological Evaluation

Dehui Kong, Tyler Fahrenhorst‐Jones, Andy Kuo, Jacinta L. Simmons et autres

-1-azacubane-2-carboxylic acid, was incorporated into a range of bioactive chemical templates, including enalaprilat, perindoprilat, endomorphin-2 and isoniazid, and subjected to biological testing. The endomorphin-2 derivative displayed increased activity at the δ opioid receptor, but a loss in activity was observed in the …

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1091 Tigilanol Tiglate is a small molecule oncolytic that induces immunogenic cell death and promotes immune cell infiltration into human tumors

Jason K. Cullen, Pei-Yi Yap, Blake Ferguson, Zara C. Bruce et autres

Background Tigilanol Tiglate (TT) is a novel small molecule under development for local treatment of solid tumours via intratumoral (I.T.) injection. TT is a protein kinase C (PKC)/C1 domain activator that disrupts tumour vasculature and causes direct oncolysis of tumour cells. Together, …

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Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck

Priscila Oliveira de Lima, Natasa Broit, Johnson Huang, Jae Hoon Lim et autres

Introduction Cutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system. This metastatic process is called perineural invasion (PNI) and spread (PNS). An in vivo sciatic nerve mouse model is …

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