Sharon Chow

Inhibition of BRN2 in melanoma reverses anoikis resistance and sensitizes cells to killing by vemurafenib

Hannah M. Neuendorf, Heping Xie, Mark N. Adams, Sharon Chow et autres

Abstract Anoikis is an apoptotic cell death program triggered upon detachment from surrounding extracellular structures. However, the ability to evade cell death by anoikis in the presence of apoptosis-inducing stimuli is necessary for the formation of malignant tumors and progression to metastasis. …

au, bd (code pays fourni par la source)

Corrigendum to “β-Triketones from Leptospermum scoparium (mānuka) oil show potential as scabicides” [Phytomedicine Volume 136, January 2025, 156321]

Nirupama A Nammunige, Kylie A. Agnew-Francis, Deepani D. Fernando, Sara Taylor et autres

au (code pays fourni par la source)

PFAS free chemically amplified resists enabled by low activation energy hydrocarbon cage monomers

Yizhou Liu, Matthew D. Summersgill, Han‐Hao Cheng, Sharon Chow et autres

Larger cage hydrocarbon induced hyperconjugation lowers the energy barrier for resist deprotection ( i.e. , solubility switching), eliminating the need for PFAS-containing PAGs for photoresist design.

au (code pays fourni par la source)

Fragrances of Cage Bicyclic Benzene Bioisosteres

Grace R. M. O'Donohue, Sharon Chow, Sevan D. Houston, Thi Le Thoa Nguyen et autres

Cubane, bicyclo[1.1.1]pentane (BCP) and bicyclo[2.2.2]octane derivatives of benzene-containing fragrances (e. g., benzyl esters) were prepared to evaluate whether odor characteristics would be retained to give same or similar scents. It was observed that each molecule maintained a distinctive aroma, sometimes quite similar …

au (code pays fourni par la source)

β-Triketones from Leptospermum scoparium (mānuka) oil show potential as scabicides

Nirupama A Nammunige, Kylie A. Agnew‐Francis, Deepani D. Fernando, Sara Taylor et autres

au (code pays fourni par la source)

In search of herbistasis: COT-metsulfuron methyl displays rare herbistatic properties

Hui Lin Xing, Sarah K. M. McGregor, Bruna Durante Batista, Cassidy Whitefield et autres

Halting weed growth through herbistasis is not a well-known phenomenon, but it could offer a new avenue for weed control. A bioisosteric cyclooctatetraene for phenyl ring replacement tactic has unearthed a rare herbistatic against rubber vine.

au (code pays fourni par la source)

Hyperstable alkenes: are they remarkably unreactive?

Matthew D. Summersgill, Lawrence R. Gahan, Sharon Chow, Gregory K. Pierens et autres

systems meeting the criteria of a hyperstable alkene have been reported in the literature. A one-pot, telescoped synthesis, of four hyperstable alkenes is reported herein, which has uncovered unexpected reactivity towards oxidation. Although, this work represents a new benchmark in hyperstable alkenes, …

au (code pays fourni par la source)

seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe)

Yongbo Xue, Andrei I. Savchenko, Kylie A. Agnew‐Francis, Jared A. Miles et autres

Cynanchum viminale subsp. australe, more commonly known as caustic vine, is a leafless succulent that grows in the northern arid zone of Australia. Toxicity toward livestock has been reported for this species, along with use in traditional medicine and its potential anticancer …

cn, au, us (code pays fourni par la source)

Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

July Carolina Romero, Cynthia A. Berlinicke, Sharon Chow, Yukan Duan et autres

Introduction Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains challenging. Brain microphysiological systems (bMPS, e.g. organoids) …

us (code pays fourni par la source)

CCDC 2216764: Experimental Crystal Structure Determination

Christian J. Bettencourt, Tanja Krainz, Sharon Chow, Brendan T. Parr et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2216763: Experimental Crystal Structure Determination

Christian J. Bettencourt, Tanja Krainz, Sharon Chow, Brendan T. Parr et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2216762: Experimental Crystal Structure Determination

Christian J. Bettencourt, Tanja Krainz, Sharon Chow, Brendan T. Parr et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …