Accès ouvert
2023
article
OpenAlex
Nicholas A. Devanney, Sangderk Lee, Holden C. Williams, Elizabeth J. Allenger et autres
Abstract Background Metabolic dysfunction and neuroinflammation characterize Alzheimer’s disease (AD), but it is unclear if these two facets of the disease are linked. The E4 allele of Apolipoprotein E (APOE) is the strongest genetic risk factor for late‐onset AD and is associated …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T Smith et autres
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk, single-cell, and spatial transcriptomics with cell-specific and spatially …
us
(code pays fourni par la source)
2022
article
OpenAlex
Cathryn T Smith, Cassi M. Friday, Nicholas A. Devanney, Elizabeth J. Allenger et autres
Abstract Background The microglial immune response is a significant contributor to Alzheimer’s disease (AD) pathophysiology and neurodegeneration. Aging microglia accumulate lipid droplets (LDs), have high levels of reactive oxygen species, secrete pro‐inflammatory cytokines, and are defective in phagocytosis. The E4 allele of …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Nicholas A. Devanney, Sangderk Lee, Holden C. Williams, Elizabeth J. Allenger et autres
Abstract Background Metabolic dysfunction and neuroinflammation characterize Alzheimer’s disease (AD), but it is unclear if these two facets of the disease are linked. The E4 allele of Apolipoprotein E (APOE) is the strongest genetic risk factor for late‐onset AD and is associated …
us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T Smith et autres
Summary The E4 allele of Apolipoprotein E ( APOE ) is associated with both metabolic dysfunction and a heightened pro-inflammatory response – two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk, single-cell, and spatial transcriptomics …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron et autres
BACKGROUND: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer's disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest genetic predictor of late-onset AD. While this clinical feature has been …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Ramon C. Sun, Lyndsay E.A. Young, Ronald C. Bruntz, Kia Hjulmand Markussen et autres
us, es
(code pays fourni par la source)
Accès ouvert
2021
dataset
OpenAlex
Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron et autres
Additional file 1. Differentially expressed genes in astrocytes (E4/E4 vs E3/E3).
Accès ouvert
2020
preprint
OpenAlex
Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron et autres
Abstract Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the E4 allele of Apolipoprotein E (APOE), the strongest genetic predictor of late-onset AD. While this clinical feature has been …
us
(code pays fourni par la source)