Lyndsay E.A. Young

Single-cell mass spectrometry imaging: platform advances for multimodal spatial omics

Lauren E Hill, Lyndsay E.A. Young, James W. Dressman, P Angel et autres

Spatial omics has transformed biomedical research by uncovering the molecular characterization of biological systems while preserving spatial context. Among these approaches, mass spectrometry imaging (MSI) provides a label-free, in situ visualization of diverse molecular classes, including metabolites, lipids, proteins, and glycans. Recent …

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Hyperglycosylation is a metabolic driver of Alzheimer’s disease

Tara R. Hawkinson, Zizhen Liu, Roberto A. Ribas, Terrymar Medina et autres

Alzheimer's disease (AD) is a devastating neurodegenerative disorder marked by progressive cognitive decline. Metabolic disruptions are widely observed, yet their involvement in the molecular aetiology of AD remains underexplored. Here we identify hyperglycosylation as a driver of AD. Integrating spatial metabolomics, lipidomics …

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Figure S4 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

ROC data for N-glycan biomarkers

Table S6 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

MET sites

Figure S13 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

Annotated LCMS spectra for COL1A1

Table S1 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

Glycan Peak List

Figure S3 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

Glycan Classification Visual

Table S3 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

Collagenase-digested peptide LCMS list

Figure S12 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

Annotated LCMS spectra for COL1A1

Figure S5 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

MALDI Images from EndoF3 digestion

Figure S18 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

Table of biomarker candidates

Figure S6 from Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Jordan P. Hartig, Kaitlyn Bejar, Lyndsay E.A. Young, Grace Grimsley et autres

MALDI Images from EndoF3 digestion with 5 TMAs