Accès ouvert
2023
supplementary-materials
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
List of Primers.
Accès ouvert
2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 1: Cytoplasmic PTHrP protein levels are reduced in breast cancer cells relative to normal breast epithelial cells. Quantification of cytoplasmic PTHrP protein levels in a progression array of normal, DCIS, primary invasive breast cancer (grades 1-3; IDC1-3), and lymph node …
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2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 7: Schematic representation of structure of wildtype Stat5a and Stat5b, dominant-negative Stat5 (DN-Stat5) and constitutively-active Stat5 (CA-Stat5) proteins.
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2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 2: Positive correlation between nuclear PTHrP and nuclear pY-Stat5 protein levels across progression series of breast cancer. Scatterplot of nuclear PTHrP and nuclear pY-Stat5 protein levels in normal breast epithelia, ductal carcinoma in situ (DCIS), primary invasive breast cancer (IDC), …
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2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 6: Nuclear PTHrP and nuclear pY-Stat5 protein levels are strongly positively correlated independent of breast cancer subtype. Scatterplot of nuclear PTHrP protein levels against nuclear pY-Stat5 levels according to immunohistochemistry-based subtyping. Regression lines were fitted using robust MM-estimation illustrating strong …
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2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 5: Higher nuclear PTHrP protein levels are associated with lower grade and estrogen receptor-positive (ER+) breast cancer. Nuclear PTHrP protein levels are significantly higher in well-differentiated, grade 1 tumors compared to grade 3 tumors (A) and significantly higher in ER-positive …
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2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 4: Low PTHrP transcript levels are associated with poor clinical outcome in KM-plotter breast cancer dataset. Association with outcome for PTHrP transcript levels in all breast cancer breast cancer cases (N=3,951) using overall survival as endpoint and 10-year censoring from …
Accès ouvert
2023
supplementary-materials
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Clinical Characteristics of Outcome Cohorts 1 and 2.
Accès ouvert
2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 3: Low PTHrP transcript levels in breast cancer are associated with poor overall survival in estrogen receptor-positive (ER+) breast cancer and in lymph node(LN)-negative breast cancer. Association with outcome for PTHrP transcript levels in breast cancer using overall survival as …
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2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
AbstractPurpose: Parathyroid hormone-related protein (PTHrP) is required for normal mammary gland development and biology. A PTHLH gene polymorphism is associated with breast cancer risk, and PTHrP promotes growth of osteolytic breast cancer bone metastases. Accordingly, current dogma holds that PTHrP is upregulated …
Accès ouvert
2023
other
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
AbstractPurpose: Parathyroid hormone-related protein (PTHrP) is required for normal mammary gland development and biology. A PTHLH gene polymorphism is associated with breast cancer risk, and PTHrP promotes growth of osteolytic breast cancer bone metastases. Accordingly, current dogma holds that PTHrP is upregulated …
Accès ouvert
2023
supplementary-materials
OpenAlex
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Clinical Characteristics of Outcome Cohorts 1 and 2.