Tamoghna Mandal

Proteome-wide CETSA reveals diverse apoptosis-inducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery

Anderson Daniel Ramos, Ying Yu Liang, Olga V. Surova, Marc-Antoine Gerault et autres

Cellular phenotypes of apoptosis, as well as the activation of apoptosis caspase cascades, are well described. However, sequences and locations of early biochemical effector events after apoptosis initiation are still only partly understood. Here, we use integrated modulation of protein interaction states-cellular …

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Efficacy of combined targeted therapy with PI3K and CDK4/6 or PARP and WEE1 inhibitors in neuroblastoma cell lines

Monika Lukoseviciute, Stefan Holzhauser, Eleni Pappa, Tamoghna Mandal et autres

Neuroblastoma (NB), the most frequent solid extracranial tumor in children, is not always cured by current aggressive therapies that have notable adverse effects; therefore, novel treatments are necessary. Phosphoinositide 3‑kinase (PI3K) and fibroblast growth factor receptor inhibitors exhibit synergistic effect in NB …

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A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML

Shiva Bamezai, Alex Jose Pulikkottil, Tribhuwan Yadav, Vegi M. Naidu et autres

RNA-binding proteins (RBPs) form a large and diverse class of factors, many members of which are overexpressed in hematologic malignancies. RBPs participate in various processes of messenger RNA (mRNA) metabolism and prevent harmful DNA:RNA hybrids or R-loops. Here, we report that PIWIL4, …

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TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways

Alex Jose Pulikkottil, Shiva Bamezai, Tobias Ammer, Fabian Mohr et autres

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Targeting leukemic stem cells in a murine model of CALM-AF10 positive acute myeloid leukemia

Tamoghna Mandal

We show that the leukemic LSC clone in the CALM-AF10 leukemia mouse model B220+Mac1- can be regenerated by B220+Mac1+ subpopulation in transplanted mice. In vivo experiments showed that the B220+Mac1+ cells could give rise to the B220+Mac1- cell compartment enriched in LSC …

The ParaHox gene Cdx4 induces acute erythroid leukemia in mice

Silvia Thoene, Tamoghna Mandal, Vegi M. Naidu, Leticia Quintanilla‐Martínez et autres

Acute erythroid leukemia (AEL) is a rare and aggressive form of acute leukemia, the biology of which remains poorly understood. Here we demonstrate that the ParaHox gene CDX4 is expressed in patients with acute erythroid leukemia, and that aberrant expression of Cdx4 …

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Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles

Tamoghna Mandal, Michaela Beck, Nicole Kirsten, Mika Lindén et autres

Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 antibody …

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Super‐Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona

Natàlia Feiner‐Gracia, Michaela Beck, Sílvia Pujals, Sébastien Tosi et autres

The adsorption of serum proteins, leading to the formation of a biomolecular corona, is a key determinant of the biological identity of nanoparticles in vivo. Therefore, gaining knowledge on the formation, composition, and temporal evolution of the corona is of utmost importance …

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Targeting leukemic stem cells by antibody functionalized mesoporous silica nanoparticles in murine aml model

Tamoghna Mandal, Michaela Beck, Nicole Kirsten, Mika Lindén et autres

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Serum Protein Adsorption Enhances Active Leukemia Stem Cell Targeting of Mesoporous Silica Nanoparticles

Michaela Beck, Tamoghna Mandal, Christian Buske, Mika Lindén

The functionalization of nanoparticles with a ligand targeting receptors overexpressed by the target cells is a commonly used strategy when aiming at nanoparticle-based, cell type-specific drug delivery.1-4 However, the influence of particle surface chemistry on the targetability has received much less attention. …

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Targeting of Leukemic Stem Cells By Antibody Functionalized Mesoporous Silica Nanoparticles in a Mouse Model of CALM-AF10 Positive Acute Myeloid Leukemia

Tamoghna Mandal, Michaela Beck, Mika Lindén, Christian Buske

Abstract Acute myeloid leukemia has still a dismal prognosis with up to 8 of 10 patients relapsing despite dose intense chemotherapies. AML is propagated by so called leukemic stem cells (LSCs), which are considered to be the cell population responsible for relapse. …

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VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice

Eva Gentner, Vegi M. Naidu, Medhanie Assmelash Mulaw, Tamoghna Mandal et autres

// Eva Gentner 1 , Naidu M. Vegi 1 , Medhanie A. Mulaw 1 , Tamoghna Mandal 1 , Shiva Bamezai 1 , Rainer Claus 2 , Alpaslan Tasdogan 3 , Leticia Quintanilla-Martinez 4 , Alexander Grunenberg 5 , Konstanze Döhner 5 …

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