Mariia Mikhaleva

Genetic instability profile in individuals exposed to low doses of ionizing radiation: A pilot study

Mariia Mikhaleva, V. Yudina, Kira A. Ivanova, M. P. Bakay et autres

Introduction. Ionizing radiation is a mutagen that exerts a significant impact on the hematopoietic system. It is hypothesized that the initiating link in radiation-induced pathological processes, including the development of clonal hematopoiesis and subsequent malignant transformation, is genetic instability in hematopoietic stem …

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Efficacy of Bruton tyrosine kinase inhibitors in mantle cell lymphoma with central nervous system involvement: a meta-analysis

Евгений Олегович Куневич, Mariia Mikhaleva, Nadezhda N. Nemstsveridze, Sergey Voloshin et autres

Background. Mantle cell lymphoma (MCL) is a highly aggressive disease characterized by rapid progression, with central nervous system (CNS) involvement reported in 1–4 % of cases, significantly worsening outcomes. Bruton tyrosine kinase (BTK) inhibitors have shown promising results in treating MCL; however, …

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Central nervous system involvement in CLL: an international retrospective study by ERIC, the European Research Initiative on CLL

Thomas Chatzikonstantinou, Mariia Mikhaleva, Christian Brieghel, Christina Papangelou et autres

ABSTRACT: Central nervous system involvement (CNSi) of chronic lymphocytic leukemia (CLL) is a rare condition with no consensus on diagnostic criteria and limited evidence for management and outcome. Here, we report an international, multicenter, retrospective study conducted by the European Research Initiative …

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Mutations and translocations associated with venetoclax resistance in chronic lymphocytic leukemia

Kiyomi Mashima, Yanan Kuang, Stacey M. Fernandes, Benjamin Hanna et autres

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Characteristics and outcomes of patients with double refractory and double exposed chronic lymphocytic leukemia

Jeongsook Yoon, Yinglu Zhou, Mariia Mikhaleva, Daniel Sungchul Choi et autres

ABSTRACT: We analyzed the characteristics and outcomes of 95 patients with chronic lymphocytic leukemia (CLL) after Bruton tyrosine kinase inhibitor (BTKi) and B-cell lymphoma 2 inhibitor (BCL2i) failure. To clearly distinguish sensitivity and resistance to the targeted treatment classes, we defined double …

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Bruton Tyrosine Kinase Inhibitors for the Treatment of Relapsed Mantle Cell Lymphoma Involving CNS: Two Case Reports and Literature Review

Евгений Олегович Куневич, Nadezhda N. Nemstsveridze, Mariia Mikhaleva, Alexey Kuvshinov et autres

Mantle cell lymphoma (MCL) accounts for 3–10 % of all non-Hodgkin lymphoma variants and is characterized by its aggressive course with frequent relapses and extranodal lesions. Due to more effective systemic chemotherapy and, as a consequence of this, increased life expectancy, relapse …

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The phenomenon of clonal hematopoiesis: etiology, classification and its prognostic role

Mariia Mikhaleva, О. Б. Крысюк, Alexander N. Bogdanov, Anastasiia Zherniakova et autres

The phenomenon of clonal hematopoiesis (CH) has been the subject of intensive research since 2014, facilitated by the development of high‑throughput sequencing technology. with age, the prevalence of CH increases, which is associated with an increased risk of hematological and cardiovascular diseases, …

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Chronic Lymphocytic Leukemia: A Genomic Landscape and Cellular Signal Pathways

Mariia Mikhaleva, Евгений Олегович Куневич, Alexey Kuvshinov, Sergey Voloshin

Genomic diagnostic methods, developed and improved in recent decades, allow a deeper understanding of pathogenic diversity of chronic lymphocytic leukemia (CLL) across all aspects from the concepts of tumor cellular origin and its reactive microenvironment to molecular landscape and genetic prognostic markers. …

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Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia

Abi Vijenthira, Virginia Olivia Volpe, Aswin Sekar, Roberta Santos Azevedo et autres

ABSTRACT: Clonal hematopoiesis of indeterminate potential (CHIP) in patients with chronic lymphocytic leukemia (CLL) has not been extensively characterized. The objective of this study was to describe the prevalence of myeloid CHIP (M-CHIP) in patients with CLL, and to determine its association …

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Perspectives for next generation sequencing in patients with follicular lymphoma

Irina Martynkevich, Mariia Mikhaleva, Alexander N. Bogdanov, Ekaterina Motyko et autres

Aim. To study the prognostic significance of gene mutations and intracellular signaling pathways involved in lymphomagenesis in patients with follicular lymphoma using next generation sequencing (NGS).Materials and methods. The prospective study included 26 patients with a median age of 51.5 years. Mutational …

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