Juan Ignacio Dapás

Isavuconazole Therapy for Patients with Hematologic Diseases and Hematopoietic Cell Transplantation with and Without Breakthrough Invasive Fungal Infections

Fabián Herrera, Diego Torres, Gustavo‐Adolfo Méndez, Noelia Mañez et autres

There are no data available on the effectiveness and safety of isavuconazole (ISA) for treating breakthrough invasive fungal infections (bIFIs). A retrospective and prospective cohort study was conducted between January 2020 and March 2025 in 13 centers in Argentina. Hematologic diseases (HD) …

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Isavuconazole Therapy for Patients with Hematologic Diseases and Hematopoietic Stem Cell Transplantation with and without Breakthrough Invasive Fungal Infections

Fabián Herrera, Diego Torres, Gustavo‐Adolfo Méndez, Noelia Mañez et autres

There are no data available on the effectiveness and safety of isavuconazole (ISA) for treating breakthrough invasive fungal infections (bIFIs). A retrospective and prospective cohort study was conducted between January 2020 and March 2025 in 13 centers in Argentina. Hematologic diseases (HD) …

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388. Spinal Implant Infections Treated with Debridement and Hardware Retention

Cynthia Rivero, Santiago Martínez, Orlando Pardo, Segundo Fuego et autres

Abstract Background Surgical site infections following spinal surgery affect 0. 3 to 20% of patients. The longer the infection, the greater the chance of antibiotic treatment failure due to the establishment of mature microbial biofilm on the hardware, requiring its removal for …

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Clinical and microbiological features of native vertebral osteomyelitis (NVO) in adults: a retrospective analysis from a private hospital of Mendoza, Argentina

Cynthia Rivero, Cintia Jahan, Juan Ignacio Dapás, Andrea Vila

Background: NVO in adults is often due to hematogenous seeding.Due to its insidious presentation, the diagnosis is often delayed and may initially be mismanaged as a degenerative process. Staphylococci are the most frequent involved microorganisms. Reports from Argentina are scarce. We describe …

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Antimicrobial Stewardship in Low- and Middle-Income Countries

Juan Ignacio Dapás, Rodolfo Quirós

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Pseudomonas aeruginosa Infective Endocarditis Following Transcatheter Aortic Valve Implantation: A Note of Caution

Juan Ignacio Dapás, Cynthia Rivero, Pablo Burgos, Andrea Vila

Transcatheter aortic valve implantation (TAVI) is an alternative treatment for severe aortic valve stenosis (AS) in patients with prohibitive risk for surgical aortic valve replacement (SAVR). Prosthetic valve endocarditis (PVE) is a rare complication of this relatively novel procedure and current guidelines …

Bacteremia Due to Escherichia coli With the Plasmid-Mediated Colistin Resistance (COL-R) mcr-1 Gene

Andrea Vila, Cynthia Vanesa Rivero, Mariana Chumbita, Juan Ignacio Dapás et autres

Background. Mcr (Mobile COL-R)-1 gene was originally described in 2015 in China in commensal E. coli from animals. It encodes a phosphor ethanol amine transferase, which confers transferable plasmid-mediated COL-R. Subsequently mcr-1 gene was reported in Enterobacteriaceae isolated from animals and meat …

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Evaluation of Peripherally Inserted Central Catheter (PICC) Complications in Patients Requiring Outpatient Parenteral Antimicrobial Therapy (OPAT)

Andrea Vila, Cynthia Rivero, Roberto Furnari, Orlando Pardo et autres

Background. OPAT enables prompt discharge of selected patients (pts) requiring long-term intravenous antimicrobial (AM) therapy. We report a cohort of pts in which PICC was used for OPAT in Argentina. Methods. We review data of 514 PICC inserted between 2003 and 2016 …

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