James Α. Baker

Abstract 5795: The discovery of BLU-020: A potent and selective degrader of CDK2 for the treatment of CCNE1 aberrant cancers

Phil Ramsden, Dean Zhang, Maria S. Iliou, Suhasini Parimi et autres

Abstract Background: Cyclin E1 is the catalytic binding partner of CDK2, which becomes aberrantly activated when CCNE1 is amplified and overexpressed, driving tumorigenesis. Tumors with aberrant cyclin E1 expression are highly dependent on Cyclin E1/CDK2 activity, presenting a distinct therapeutic opportunity. Selective …

us (code pays fourni par la source)

PATH-SAFE Consortium Recommendations for Genomic Surveillance of Foodborne Diseases, Using Salmonella as an Exemplar

Tim Dallman, Martin C. J. Maiden, Keith A. Jolley, David L. Gally et autres

By Food Standards Agency, Tim Dallman & 47 more. The purpose of this report is to act as a standard reference for methodologies for genomic surveillance of FBD. The recommendations have been developed using non-typhoidal Salmonella as an example.

nl, gb, th, jp, fr, au, dk, us (code pays fourni par la source)

BLU-808: A Potent and Selective Oral Small Molecule Wild-Type KIT Tyrosine Kinase Inhibitor for Allergic Conditions

Megan A. Hatlen, Andrew M. Haidle, Doug Wilson, Priyanka Sawant et autres

us (code pays fourni par la source)

Strengthening Regional Cooperation for Marine Litter Management in Indonesia, the Philippines, Thailand, and Viet Nam: Policy Analysis and Opportunities

Anna Oposa, James Α. Baker

Identifying Southeast Asia as a major source of marine plastic pollution, this brief compares plans by Indonesia, the Philippines, Thailand, and Viet Nam to tackle marine litter and shows how they can work toward a circular plastics economy.

jp, us, ph (code pays fourni par la source)

BRAT: Bonus oRthogonAl Token for Architecture Agnostic Textual Inversion

James Α. Baker

Textual Inversion remains a popular method for personalizing diffusion models, in order to teach models new subjects and styles. We note that textual inversion has been underexplored using alternatives to the UNet, and experiment with textual inversion with a vision transformer. We …

BLU-808, a Potent and Selective Small Molecule Inhibitor of Wild-type c-KIT for Mast Cell Disorders

Alexandra R. Grassian, Andrew M. Haidle, Sophia AuDuong, James Α. Baker et autres

us (code pays fourni par la source)

Stable isotopes indicate reduced body condition of caribou in disturbed areas

Rob Found, James Α. Baker, John M. Fryxell, Ashley A. D. Mclaren et autres

Abstract Understanding the impacts of disturbance on individual fitness is important for wildlife management, and critical for the conservation of species at risk. We compared the fitness and seasonal range use of 39 woodland caribou in Ontario study areas contrasted by their …

ca (code pays fourni par la source)

Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey

Carl Johan Petersson, Xin Zhou, Joerg Berghausen, David Álvaro Cebrián et autres

de, us, ch, gb, fr, ca (code pays fourni par la source)

Correlations between energy and $γ$-ray emission in $^{239}\mathrm{Pu}(n,\mathrm{f})$

Nathan P. Giha, Stefano Marin, James Α. Baker, Isabel E. Hernandez et autres

We study $γ$-ray emission following $^{239}\mathrm{Pu}(n,\mathrm{f})$ over an incident neutron energy range of $2 < E_i < 40$ MeV. We present the first experimental evidence for positive correlations between the total angular momentum generated in fission and the excitation energy of the …

Combination of EP 4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

Yun Wang, Long Cui, Peter Georgiev, Latika Singh et autres

Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP1-4). Specific targeting of EP receptors, as opposed to COX-1/2 inhibition, has been proposed …

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Anthropogenic Disturbance and Population Viability of Woodland Caribou in Ontario

John M. Fryxell, Tal Avgar, Boyan Liu, James Α. Baker et autres

ABSTRACT One of the most challenging tasks in wildlife conservation and management is to clarify how spatial variation in land cover due to anthropogenic disturbance influences wildlife demography and long‐term viability. To evaluate this, we compared rates of survival and population growth …

ca, us (code pays fourni par la source)

CHARACTERIZING GROUNDWATER-SURFACE WATER CONNECTIONS AND GEOCHEMICAL FLUXES WITHIN AN URBAN WATERSHED USED FOR PUBLIC WATER SUPPLY

Austen York, Donald Reeves, James Α. Baker, Jean Talanda et autres

us (code pays fourni par la source)