Peter Georgiev

Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-mediated Disease 2259241

Mohammad Adeel Zafar, Charlotte Nicole Hill Machado, Jyotirmaya Behera, Yuelin Zhong et autres

Foxp3 deficiency causes a profound loss of immune tolerance, unleashing autoreactive T and B cells, lymphoproliferation, cytokine-driven inflammation, and autoantibody production. This autoimmune pathology is fueled by increased glutamine usage, but it remains unresolved whether glutamine is necessary to produce energy or …

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Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

Peter Georgiev, Sheila E. Johnson, Kiran Kurmi, Song-Hua Hu et autres

ABSTRACT Amino acids play critical roles in the activation and function of lymphocytes. Here we show that the non-essential amino acid, asparagine, is essential for optimal activation and proliferation of CD4 + T cells. We demonstrate that asparagine depletion at different time …

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Author response: Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

Peter Georgiev, Sheila Johnson, Kiran Kurmi, Song-Hua Hu et autres

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Figure S5 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 5

Figure S1 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 1

Figure S7 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 7

Figure S4 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 4

Figure S2 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 2

Figure S6 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 6

Figure S3 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 3

Figure S8 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

Supplemental Figure 8

Author response: Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

Peter Georgiev, Sheila Johnson, Kiran Kurmi, Song-Hua Hu et autres

Amino acids play critical roles in the activation and function of lymphocytes. Here we show that the non-essential amino acid, asparagine, is essential for optimal activation and proliferation of CD4+ T cells. We demonstrate that asparagine depletion at different time points after …